日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Functional and Structural Characterization of LRRK2 p.V1447L in Parkinson's Disease

帕金森病中LRRK2 p.V1447L的功能和结构特征

Pratuseviciute, Neringa; Lis, Pawel; Weber, Sacha; Gruchy, Nicolas; Arnaud, Lionel; Alessi, Dario R; Sammler, Esther

PPM1M, an LRRK2-counteracting, phosphoRab12-preferring phosphatase with a potential link to Parkinson's disease.

PPM1M 是一种 LRRK2 拮抗剂,优先结合磷酸化 Rab12 的磷酸酶,可能与帕金森病有关。

Chiang Claire Y, Pratuseviciute Neringa, Lin Yu-En, Adhikari Ayan, Yeshaw Wondwossen M, Flitton Chloe, Sherpa Pemba L, Tonelli Francesca, Rektorova Irena, Lynch Timothy, Siuda Joanna, Rudzińska-Bar Monika, Pulyk Oleksandr, Bauer Peter, Beetz Christian, Dickson Dennis W, Ross Owen A, Wszolek Zbigniew K, Fang Zih-Hua, Klein Christine, Zimprich Alexander, Alessi Dario R, Sammler Esther M, Pfeffer Suzanne R

The New p.F1700L LRRK2 Variant Causes Parkinson's Disease by Extensively Increasing Kinase Activity

新的p.F1700L LRRK2变异体通过大幅增强激酶活性导致帕金森病。

Borsche, Max; Pratuseviciute, Neringa; Schaake, Susen; Hinrichs, Frauke; Morel, Gabriel; Uter, Jan; Lohmann, Katja; Klein, Christine; Alessi, Dario R; Hagenah, Johann; Sammler, Esther

R1441G but not G2019S mutation enhances LRRK2 mediated Rab10 phosphorylation in human peripheral blood neutrophils

R1441G 而非 G2019S 突变可增强人类外周血中性粒细胞中 LRRK2 介导的 Rab10 磷酸化

Ying Fan, Raja S Nirujogi, Alicia Garrido, Javier Ruiz-Martínez, Alberto Bergareche-Yarza, Elisabet Mondragón-Rezola, Ana Vinagre-Aragón, Ioana Croitoru, Ana Gorostidi Pagola, Laura Paternain Markinez, Roy Alcalay, Richard A Hickman, Jonas Düring, Sara Gomes, Neringa Pratuseviciute, Shalini Padmanab