日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Elucidation of Mechanism of Action in Drug Invention: Using Stable Isotope Tracers to Unravel Biochemical Kinetics

药物研发中作用机制的阐明:利用稳定同位素示踪剂揭示生化动力学

Kohnz, Rebecca A; Zhou, Dan; Lou, Bin; Yao, Huifang; McKenney, David; Dokwal, Dhiraj; Villanueva, Ruth; Kocalis, Heidi; Ballard, Jeanine E; Piesvaux, Jennifer; Previs, Stephen F

A Novel Biomarker of Neuronal Glutamate Metabolism in Nonhuman Primates Using Localized (1)H-Magnetic Resonance Spectroscopy: Development and Effects of BNC375, an α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulator

利用局部(1)H-磁共振波谱法在非人灵长类动物中发现一种新型神经元谷氨酸代谢生物标志物:α7尼古丁乙酰胆碱受体正向变构调节剂BNC375的开发和作用

Miller, Corin O; Gantert, Liza T; Previs, Stephen F; Chen, Ying; Anderson, Kenneth D; Thomas, Justina M; Sanacora, Gerard; Uslaner, Jason M; Rothman, Douglas L; Mason, Graeme F

Glycation Reduces the Stability of ApoAI and Increases HDL Dysfunction in Diet-Controlled Type 2 Diabetes

糖化作用降低载脂蛋白AI的稳定性,并加剧饮食控制的2型糖尿病患者的高密度脂蛋白功能障碍。

Kashyap, Sangeeta R; Osme, Abdullah; Ilchenko, Serguei; Golizeh, Makan; Lee, Kwangwon; Wang, Shuhui; Bena, James; Previs, Stephen F; Smith, Jonathan D; Kasumov, Takhar

CETP (Cholesteryl Ester Transfer Protein) Inhibition With Anacetrapib Decreases Production of Lipoprotein(a) in Mildly Hypercholesterolemic Subjects

阿那西曲匹抑制CETP(胆固醇酯转移蛋白)可降低轻度高胆固醇血症患者的脂蛋白(a)生成

Thomas, Tiffany; Zhou, Haihong; Karmally, Wahida; Ramakrishnan, Rajasekhar; Holleran, Stephen; Liu, Yang; Jumes, Patricia; Wagner, John A; Hubbard, Brian; Previs, Stephen F; Roddy, Thomas; Johnson-Levonas, Amy O; Gutstein, David E; Marcovina, Santica M; Rader, Daniel J; Ginsberg, Henry N; Millar, John S; Reyes-Soffer, Gissette

Evaluation of CETP activity in vivo under non-steady-state conditions: influence of anacetrapib on HDL-TG flux

在非稳态条件下评估体内CETP活性:阿那西曲匹对HDL-TG通量的影响

McLaren, David G; Previs, Stephen F; Phair, Robert D; Stout, Steven J; Xie, Dan; Chen, Ying; Salituro, Gino M; Xu, Suoyu S; Castro-Perez, Jose M; Opiteck, Gregory J; Akinsanya, Karen O; Cleary, Michele A; Dansky, Hayes M; Johns, Douglas G; Roddy, Thomas P

Gaussian Process Modeling of Protein Turnover

蛋白质周转的高斯过程建模

Rahman, Mahbubur; Previs, Stephen F; Kasumov, Takhar; Sadygov, Rovshan G

Lipidome of atherosclerotic plaques from hypercholesterolemic rabbits

高胆固醇血症兔动脉粥样硬化斑块的脂质组学

Bojic, Lazar A; McLaren, David G; Shah, Vinit; Previs, Stephen F; Johns, Douglas G; Castro-Perez, Jose M

Tracking fatty acid kinetics in distinct lipoprotein fractions in vivo: a novel high-throughput approach for studying dyslipidemia in rodent models

体内追踪不同脂蛋白组分中的脂肪酸动力学:一种研究啮齿动物血脂异常的新型高通量方法

McLaren, David G; Wang, Sheng-Ping; Stout, Steven J; Xie, Dan; Miller, Paul L; Mendoza, Vivienne; Rosa, Raymond; Castro-Perez, Jose; Previs, Stephen F; Johns, Douglas G; Roddy, Thomas P

Measurement of apo(a) kinetics in human subjects using a microfluidic device with tandem mass spectrometry

利用微流控串联质谱法测定人体内载脂蛋白(a)的动力学

Zhou, Haihong; Castro-Perez, Jose; Lassman, Michael E; Thomas, Tiffany; Li, Wenyu; McLaughlin, Theresa; Dan, Xie; Jumes, Patricia; Wagner, John A; Gutstein, David E; Hubbard, Brian K; Rader, Daniel J; Millar, John S; Ginsberg, Henry N; Reyes-Soffer, Gissette; Cleary, Michele; Previs, Stephen F; Roddy, Thomas P

The use of stable-isotopically labeled oleic acid to interrogate lipid assembly in vivo: assessing pharmacological effects in preclinical species

利用稳定同位素标记的油酸研究体内脂质组装:评估其在临床前动物中的药理学效应

McLaren, David G; He, Timothy; Wang, Sheng-Ping; Mendoza, Vivienne; Rosa, Raymond; Gagen, Karen; Bhat, Gowri; Herath, Kithsiri; Miller, Paul L; Stribling, Sloan; Taggart, Andrew; Imbriglio, Jason; Liu, Jinqi; Chen, Dunlu; Pinto, Shirly; Balkovec, James M; DeVita, Robert J; Marsh, Donald J; Castro-Perez, Jose M; Strack, Alison; Johns, Douglas G; Previs, Stephen F; Hubbard, Brian K; Roddy, Thomas P