日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Prophylactic PDE4 and PDE4B inhibition reduce lesion size and neutrophil infiltration following ischemic stroke in male mice

预防性抑制PDE4和PDE4B可减少雄性小鼠缺血性卒中后的病灶大小和中性粒细胞浸润。

期刊:Journal of Cerebral Blood Flow and Metabolism
影响因子:4.5
doi:10.1177/0271678X251386237
Ponsaerts, Laura; Alders, Lotte; Schepers, Melissa; Kemps, Hannelore; Pirlet, Elke; Willems, Emily; De Bondt, Mirre; Jacobs, Ruben; Brullo, Chiara; Bruno, Olga; Fedele, Ernesto; Ricciarelli, Roberta; Prickaerts, Jos; Somers, Veerle; Vandenbosch, Michiel; Vanmierlo, Tim; Bronckaers, Annelies
细胞生物学
中性粒细胞
粒细胞
发表日期：2026
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Individual contribution of PDE4B and PDE4D subfamilies to the prevention of object location memory impairments induced by sleep deprivation

PDE4B 和 PDE4D 亚家族在预防睡眠剥夺引起的物体位置记忆障碍中的个体贡献

期刊:Learning & Memory
影响因子:2.2
doi:10.1101/lm.054101.125
Zhao, Hongyu; Blokland, Arjan; Prickaerts, Jos; Havekes, Robbert; Meijer, Elroy L; Heckman, Pim R A
发表日期：2025
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Amelioration of functional and histopathological consequences after spinal cord injury through phosphodiesterase 4D (PDE4D) inhibition

通过抑制磷酸二酯酶 4D (PDE4D) 改善脊髓损伤后的功能和组织病理学后果

期刊:Neurotherapeutics
影响因子:5.6
doi:10.1016/j.neurot.2024.e00372
Melissa Schepers, Sven Hendrix, Femke Mussen, Elise van Breedam, Peter Ponsaerts, Stefanie Lemmens, Niels Hellings, Roberta Ricciarelli, Ernesto Fedele, Olga Bruno, Chiara Brullo, Jos Prickaerts, Jana Van Broeckhoven, Tim Vanmierlo
神经
脊髓损伤
发表日期：2024
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Early Inhibition of Phosphodiesterase 4B (PDE4B) Instills Cognitive Resilience in APPswe/PS1dE9 Mice

早期抑制磷酸二酯酶 4B (PDE4B) 可增强 APPswe/PS1dE9 小鼠的认知韧性

期刊:Cells
影响因子:5.1
doi:10.3390/cells13121000
Ben Rombaut, Melissa Schepers, Assia Tiane, Femke Mussen, Lisa Koole, Sofie Kessels, Chloë Trippaers, Ruben Jacobs, Kristiaan Wouters, Emily Willems, Lieve van Veggel, Philippos Koulousakis, Dorien Deluyker, Virginie Bito, Jos Prickaerts, Inez Wens, Bert Brône, Daniel L A van den Hove, Tim Vanmierlo
信号转导
ELISA
发表日期：2024
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The Reliability and Clinical Validation of Automatically-Derived Verbal Memory Features of the Verbal Learning Test in Early Diagnostics of Cognitive Impairment

自动提取的言语学习测试言语记忆特征在认知障碍早期诊断中的可靠性和临床验证

期刊:Journal of Alzheimers Disease
影响因子:3.1
doi:10.3233/JAD-230608
Possemis, Nina; Ter Huurne, Daphne; Banning, Leonie; Gruters, Angelique; Van Asbroeck, Stephanie; König, Alexandra; Linz, Nicklas; Tröger, Johannes; Langel, Kai; Blokland, Arjan; Prickaerts, Jos; de Vugt, Marjolein; Verhey, Frans; Ramakers, Inez
神经科学
发表日期：2024
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A proof of concept phase II study with the PDE-4 inhibitor roflumilast in patients with mild cognitive impairment or mild Alzheimer's disease dementia (ROMEMA): study protocol of a double-blind, randomized, placebo-controlled, between-subjects trial

一项针对轻度认知障碍或轻度阿尔茨海默病痴呆患者的PDE-4抑制剂罗氟司特概念验证性II期研究（ROMEMA）：一项双盲、随机、安慰剂对照、受试者间试验的研究方案

期刊:Trials
影响因子:2
doi:10.1186/s13063-024-08001-3
Possemis, Nina; Verhey, Frans; Prickaerts, Jos; Blokland, Arjan; Ramakers, Inez
阿尔茨海默症
神经科学
发表日期：2024
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From methylation to myelination: epigenomic and transcriptomic profiling of chronic inactive demyelinated multiple sclerosis lesions

从甲基化到髓鞘形成：慢性非活动性脱髓鞘多发性硬化症病变的表观基因组学和转录组学分析

期刊:Acta Neuropathologica
影响因子:9.3
doi:10.1007/s00401-023-02596-8
Assia Tiane, Melissa Schepers, Rick A Reijnders, Lieve van Veggel, Sarah Chenine, Ben Rombaut, Emma Dempster, Catherine Verfaillie, Kobi Wasner, Anne Grünewald, Jos Prickaerts, Ehsan Pishva, Niels Hellings, Daniel van den Hove #, Tim Vanmierlo #
免疫
神经
多发性硬化症
发表日期：2023
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Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-β pathology

特定长链 PDE4D 亚型的消融可增加神经突伸长，并能防止淀粉样β蛋白病理

期刊:Cellular and Molecular Life Sciences
影响因子:6.2
doi:10.1007/s00018-023-04804-w
Dean Paes, Melissa Schepers, Emily Willems, Ben Rombaut, Assia Tiane, Yevgeniya Solomina, Amy Tibbo, Connor Blair, Elka Kyurkchieva, George S Baillie, Roberta Ricciarelli, Chiara Brullo, Ernesto Fedele, Olga Bruno, Daniel van den Hove #, Tim Vanmierlo #, Jos Prickaerts #
神经
WB
发表日期：2023
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Phosphodiesterase 4 inhibition after retrieval switches the memory fate favoring extinction instead of reconsolidation

检索后抑制磷酸二酯酶 4 会改变记忆的命运，有利于消退而不是再巩固

期刊:Scientific Reports
影响因子:3.8
doi:10.1038/s41598-023-47717-1
Jeferson Machado Batista Sohn, Nathalie Carla Cardoso, Ana Maria Raymundi, Jos Prickaerts, Cristina Aparecida Jark Stern
信号转导
WB
发表日期：2023
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Acute deletion of the central MR/GR steroid receptor correlates with changes in LTP, auditory neural gain, and GC-A cGMP signaling

中枢 MR/GR 类固醇受体的急性缺失与 LTP、听觉神经增益和 GC-A cGMP 信号传导的变化相关

期刊:Frontiers in Molecular Neuroscience
影响因子:3.5
doi:10.3389/fnmol.2023.1017761
Dila Calis, Morgan Hess, Philine Marchetta, Wibke Singer, Julian Modro, Ellis Nelissen, Jos Prickaerts, Peter Sandner, Robert Lukowski, Peter Ruth, Marlies Knipper, Lukas Rüttiger
信号转导
神经
Neuroscience
发表日期：2023
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