日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Evidence of miR‐153‐3p association with Alzheimer's disease (AD) and the mechanism of miR‐153‐3p on critical proteins suggest a therapeutic and biomarker potential of miR‐153‐3p in AD and related dementias

miR-153-3p与阿尔茨海默病(AD)的关联证据以及miR-153-3p对关键蛋白的作用机制表明,miR-153-3p在AD及相关痴呆症中具有治疗和生物标志物方面的潜力。

Shah, Viral; Giotopoulos, George; Osaki, Hikari; Meyerhöfer, Markus; Meduri, Eshwar; Gallego-Crespo, Aaron; Behrendt, Malte A; Saura-Pañella, Maria; Tarkar, Aarti; Schubert, Benedict; Yun, Haiyang; Horton, Sarah J; Agrawal-Singh, Shuchi; Haehnel, Patricia S; Basheer, Faisal; Lugo, Dave; Eleftheriadou, Ioanna; Barbash, Olena; Dhar, Arindam; Kühn, Michael W M; Guezguez, Borhane; Theobald, Matthias; Kindler, Thomas; Gallipoli, Paolo; Yeh, Paul; Dawson, Mark A; Prinjha, Rab K; Huntly, Brian J P; Sasca, Daniel; Fish, Lauren A; Canchi, Saranya; Telpoukhovskaia, Maria; Luquez, Tain; Algoo, Jonathan; Hadad, Niran; Gurdon, Brianna; Dai, Miko; Ouellette, Andrew R; Neuner, Sarah M; Dunn, Amy R; Willcox, Jon A L; Wu, Yiyang; Dumitrescu, Logan; Bellur, Orhan; Zhang, Jigang; O'Connell, Kristen MS; Dammer, Eric B; Seyfried, Nicholas T; Muzumdar, Sukalp; Gillis, Jesse; Robson, Paul; Arnold, Matthias; Hohman, Timothy J; Philip, Vivek M; Menon, Vilas; Kaczorowski, Catherine C; Lahiri, Debomoy K; Wang, Ruizhi; Maloney, Bryan; Ghetti, Bernardino; Nho, Kwangsik; Farlow, Martin R; Saykin, Andrew J; White, Fletcher A; Sambamurti, Kumar; Counts, Scott E; Rosene, Matthew J; Lopez, Abraham; Ahmad, Adeeb; Romero, Skarleth Cardenas; Lai, Mei‐Yu; Benitez, Bruno A; Tish, Margaret M; Gao, Lauren; Ou, Zihui; Weinshenker, David; Birey, Fikri; Lahiri, Debomoy K; Wang, Ruizhi; Maloney, Bryan; Ghetti, Bernardino; Nho, Kwangsik; Farlow, Martin R; Saykin, Andrew J; White, Fletcher A; Sambamurti, Kumar; Counts, Scott E

NLRP3 inflammasome-driven hemophagocytic lymphohistiocytosis occurs independent of IL-1β and IL-18 and is targetable by BET inhibitors.

NLRP3炎症小体驱动的噬血细胞性淋巴组织细胞增生症的发生与IL-1β和IL-18无关,并且是BET抑制剂的靶点

Shojaee Farzaneh, Azadian Esmaeel, Wong Min Xian, Ma Xiuquan, Rickard James, Pang Jiyi, Hall Catherine, Kueh Andrew J, Masters Seth L, Rioja Inmaculada, Prinjha Rab K, Doerflinger Marcel, Lawlor Kate E, Rashidi Maryam, Vince James E

Structure-Guided Design of a Domain-Selective Bromodomain and Extra Terminal N-Terminal Bromodomain Chemical Probe

基于结构的域选择性溴结构域和额外末端N端溴结构域化学探针的设计

Bradley, Erin; Fusani, Lucia; Chung, Chun-Wa; Craggs, Peter D; Demont, Emmanuel H; Humphreys, Philip G; Mitchell, Darren J; Phillipou, Alex; Rioja, Inmaculada; Shah, Rishi R; Wellaway, Christopher R; Prinjha, Rab K; Palmer, David S; Kerr, William J; Reid, Marc; Wall, Ian D; Cookson, Rosa

Design and Characterization of 1,3-Dihydro-2H-benzo[d]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors

1,3-二氢-2H-苯并[d]氮杂环庚酮作为符合五规则的二价BET抑制剂的设计与表征

Bamborough, Paul; Chung, Chun-Wa; Goodwin, Nicole C; Mitchell, Darren J; Neipp, Christopher E; Phillipou, Alex; Preston, Alex; Prinjha, Rab K; Soden, Peter E; Watson, Robert J; Demont, Emmanuel H

Carboxylesterase-1 Assisted Targeting of HDAC Inhibitors to Mononuclear Myeloid Cells in Inflammatory Bowel Disease

羧酸酯酶-1辅助HDAC抑制剂靶向炎症性肠病中的单核髓系细胞

Elfiky, Ahmed M I; Ghiboub, Mohammed; Li Yim, Andrew Y F; Hageman, Ishtu L; Verhoeff, Jan; de Krijger, Manon; van Hamersveld, Patricia H P; Welting, Olaf; Admiraal, Iris; Rahman, Shafaque; Garcia-Vallejo, Juan J; Wildenberg, Manon E; Tomlinson, Laura; Gregory, Richard; Rioja, Inmaculada; Prinjha, Rab K; Furze, Rebecca C; Lewis, Huw D; Mander, Palwinder K; Heinsbroek, Sigrid E M; Bell, Matthew J; de Jonge, Wouter J

A BET Protein Inhibitor Targeting Mononuclear Myeloid Cells Affects Specific Inflammatory Mediators and Pathways in Crohn's Disease

一种靶向单核髓系细胞的BET蛋白抑制剂可影响克罗恩病中的特定炎症介质和通路

Elfiky, Ahmed M I; Hageman, Ishtu L; Becker, Marte A J; Verhoeff, Jan; Li Yim, Andrew Y F; Joustra, Vincent W; Mulders, Lieven; Fung, Ivan; Rioja, Inmaculada; Prinjha, Rab K; Smithers, Nicholas N; Furze, Rebecca C; Mander, Palwinder K; Bell, Matthew J; Buskens, Christianne J; D'Haens, Geert R; Wildenberg, Manon E; de Jonge, Wouter J

Bromodomain proteins regulate human cytomegalovirus latency and reactivation allowing epigenetic therapeutic intervention

溴结构域蛋白调控人巨细胞病毒的潜伏和再激活,从而为表观遗传治疗干预提供可能。

Groves, Ian J; Jackson, Sarah E; Poole, Emma L; Nachshon, Aharon; Rozman, Batsheva; Schwartz, Michal; Prinjha, Rab K; Tough, David F; Sinclair, John H; Wills, Mark R

Novel Insights Into Rheumatoid Arthritis Through Characterization of Concordant Changes in DNA Methylation and Gene Expression in Synovial Biopsies of Patients With Differing Numbers of Swollen Joints

通过对不同肿胀关节数量患者滑膜活检中DNA甲基化和基因表达的一致性变化进行表征,获得类风湿性关节炎的新见解

Li Yim, Andrew Y F; Ferrero, Enrico; Maratou, Klio; Lewis, Huw D; Royal, George; Tough, David F; Larminie, Chris; Mannens, Marcel M A M; Henneman, Peter; de Jonge, Wouter J; van de Sande, Marleen G H; Gerlag, Danielle M; Prinjha, Rab K; Tak, Paul P

Brd2/4 and Myc regulate alternative cell lineage programmes during early osteoclast differentiation in vitro

Brd2/4 和 Myc 在体外调控早期破骨细胞分化过程中的其他细胞谱系程序

Caputo, Valentina S; Trasanidis, Nikolaos; Xiao, Xiaolin; Robinson, Mark E; Katsarou, Alexia; Ponnusamy, Kanagaraju; Prinjha, Rab K; Smithers, Nicholas; Chaidos, Aristeidis; Auner, Holger W; Karadimitris, Anastasios

Efficacy of combined CDK9/BET inhibition in preclinical models of MLL-rearranged acute leukemia

CDK9/BET联合抑制在MLL重排急性白血病临床前模型中的疗效

McCalmont, Hannah; Li, Ka Leung; Jones, Luke; Toubia, John; Bray, Sarah C; Casolari, Debora A; Mayoh, Chelsea; Samaraweera, Saumya E; Lewis, Ian D; Prinjha, Rab K; Smithers, Nicholas; Wang, Shudong; Lock, Richard B; D'Andrea, Richard J