日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PF-06526290 can both enhance and inhibit conduction through voltage-gated sodium channels

PF-06526290 既能增强也能抑制电压门控钠通道的传导。

Wang, Lingxin; Zellmer, Shannon G; Printzenhoff, David M; Castle, Neil A

The discovery of a potent Na(v)1.3 inhibitor with good oral pharmacokinetics

发现一种具有良好口服药代动力学的强效Na(v)1.3抑制剂

Pryde, D C; Swain, N A; Stupple, P A; West, C W; Marron, B; Markworth, C J; Printzenhoff, D; Lin, Z; Cox, P J; Suzuki, R; McMurray, S; Waldron, G J; Payne, C E; Warmus, J S; Chapman, M L

Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release

亚型选择性小分子抑制剂揭示 Nav1.7 在伤害感受器电生成、轴突传导和突触前释放中的基本作用

Aristos J Alexandrou, Adam R Brown, Mark L Chapman, Mark Estacion, Jamie Turner, Malgorzata A Mis, Anna Wilbrey, Elizabeth C Payne, Alex Gutteridge, Peter J Cox, Rachel Doyle, David Printzenhoff, Zhixin Lin, Brian E Marron, Christopher West, Nigel A Swain, R Ian Storer, Paul A Stupple, Neil A Castle

A novel selective and orally bioavailable Nav 1.8 channel blocker, PF-01247324, attenuates nociception and sensory neuron excitability

新型选择性口服生物利用度高的 Nav 1.8 通道阻滞剂 PF-01247324 可减弱伤害感受和感觉神经元兴奋性。

Payne, Claire Elizabeth; Brown, Adam R; Theile, Jonathon W; Loucif, Alexandre J C; Alexandrou, Aristos J; Fuller, Mathew D; Mahoney, John H; Antonio, Brett M; Gerlach, Aaron C; Printzenhoff, David M; Prime, Rebecca L; Stockbridge, Gillian; Kirkup, Anthony J; Bannon, Anthony W; England, Steve; Chapman, Mark L; Bagal, Sharan; Roeloffs, Rosemarie; Anand, Uma; Anand, Praveen; Bungay, Peter J; Kemp, Mark; Butt, Richard P; Stevens, Edward B

Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels

电压门控钠通道选择性小分子抑制剂的电压传感器相互作用位点

Ken McCormack, Sonia Santos, Mark L Chapman, Douglas S Krafte, Brian E Marron, Christopher W West, Michael J Krambis, Brett M Antonio, Shannon G Zellmer, David Printzenhoff, Karen M Padilla, Zhixin Lin, P Kay Wagoner, Nigel A Swain, Paul A Stupple, Marcel de Groot, Richard P Butt, Neil A Castle