日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The costimulatory molecule ICOS limits memory-like properties and function of exhausted PD-1+CD8+ T cells

共刺激分子ICOS限制了耗竭的PD-1+CD8+ T细胞的记忆样特性和功能。

Etienne Humblin ,Isabel Korpas ,Nataliya Prokhnevska ,Abishek Vaidya ,Dan Filipescu ,Jiahua Lu ,Verena van der Heide ,Carlos Alberto de Carvalho Fraga ,Tesia Bobrowski ,Adam Marks ,Matthew D Park ,Helder I Nakaya ,Emily Bernstein ,Brian D Brown ,Amaia Lujambio ,David Dominguez-Sola ,Brad R Rosenberg ,Alice O Kamphorst

Combination radiation and αPD-L1 enhance tumor control by stimulating CD8+ PD-1+ TCF-1+ T cells in the tumor-draining lymph node

联合放疗和αPD-L1可通过刺激肿瘤引流淋巴结中的CD8+PD-1+TCF-1+T细胞来增强肿瘤控制。

Shen, Yang; Connolly, Erin; Aiello, Meili; Zhou, Chengjing; Chappa, Prasanthi; Song, Haorui; Tippitak, Patan; Clark, Tarralyn; Cardenas, Maria; Prokhnevska, Nataliya; Mariniello, Annapaola; De Bruyker, Isabelle; Pagadala, Meghana S; Dhere, Vishal R; Rafiq, Sarwish; Kesarwala, Aparna H; Orthwein, Alexandre; Thomas, Susan N; Zhang, Shirley L; Khan, Mohammad K; Dixon, J Brandon; Lesinski, Gregory B; Lowe, Michael C; Kissick, Haydn; Yu, David S; Paulos, Chrystal M; Schmitt, Nicole C; Buchwald, Zachary S

Pre-operative stereotactic radiosurgery and peri-operative dexamethasone for resectable brain metastases: a two-arm pilot study evaluating clinical outcomes and immunological correlates

可切除脑转移瘤术前立体定向放射外科治疗和围手术期地塞米松治疗:一项评估临床结果和免疫学相关性的双臂试点研究

Jansen, Caroline S; Pagadala, Meghana S; Cardenas, Maria A; Prabhu, Roshan S; Goyal, Subir; Zhou, Chengjing; Chappa, Prasanthi; Vo, BaoHan T; Ye, Chengyu; Hopkins, Benjamin; Zhong, Jim; Klie, Adam; Daniels, Taylor; Admassu, Maedot; Green, India; Pfister, Neil T; Neill, Stewart G; Switchenko, Jeffrey M; Prokhnevska, Nataliya; Hoang, Kimberly B; Torres, Mylin A; Logan, Suzanna; Olson, Jeffrey J; Nduom, Edjah K; Del Balzo, Luke; Patel, Kirtesh; Burri, Stuart H; Asher, Anthony L; Wilkinson, Scott; Lake, Ross; Kesarwala, Aparna H; Higgins, Kristin A; Patel, Pretesh; Dhere, Vishal; Sowalsky, Adam G; Carter, Hannah; Khan, Mohammad K; Kissick, Haydn; Buchwald, Zachary S

Neoadjuvant cabozantinib restores CD8+ T cells in patients with locally advanced non-metastatic clear cell renal cell carcinoma: a phase 2 trial

新辅助卡博替尼可恢复局部晚期非转移性透明细胞肾细胞癌患者的 CD8+ T 细胞:一项 II 期试验

Bilen, Mehmet A; Vo, BaoHan T; Liu, Yuan; Greenwald, Rachel; Davarpanah, Amir H; McGuire, Donald; Shiradkar, Rakesh; Li, Liping; Nazha, Bassel; Brown, Jacqueline T; Williams, Sierra; Session, Wilena; Russler, Greta; Caulfield, Sarah; Joshi, Shreyas S; Narayan, Vikram M; Filson, Christopher P; Ogan, Kenneth; Kucuk, Omer; Carthon, Bradley Curtis; Del Balzo, Luke; Cohen, Athena; Boyanton, Adriana; Prokhnevska, Nataliya; Cardenas, Maria Andrea; Sobierajska, Ewelina; Jansen, Caroline S; Patil, Dattatraya H; Nicaise, Edouard; Osunkoya, Adeboye O; Kissick, Haydn; Master, Viraj A

Early generation of a precursor CD8 T cell that can adapt to acute or chronic viral infection

早期生成的CD8 T细胞前体能够适应急性或慢性病毒感染

McManus, Daniel T; Valanparambil, Rajesh M; Medina, Christopher B; Hu, Yinghong; Scharer, Christopher D; Sobierajska, Ewelina; Chang, Daniel Y; Wieland, Andreas; Lee, Judong; Nasti, Tahseen H; Hashimoto, Masao; Ross, James L; Prokhnevska, Nataliya; Cardenas, Maria A; Gill, Amanda L; Clark, Elisa C; Abadie, Kathleen; Kueh, Hao Yuan; Kaye, Jonathan; Au-Yeung, Byron B; Kissick, Haydn T; Ahmed, Rafi

Radiation and anti-PD-L1 synergize by stimulating a stem-like T cell population in the tumor-draining lymph node

放射线和抗PD-L1疗法通过刺激肿瘤引流淋巴结中的干细胞样T细胞群发挥协同作用。

Shen, Yang; Connolly, Erin; Aiello, Meili; Zhou, Chengjing; Chappa, Prasanthi; Song, Haorui; Tippitak, Patan; Clark, Tarralyn; Cardenas, Maria; Prokhnevska, Nataliya; Mariniello, Annapaola; Pagadala, Meghana S; Dhere, Vishal R; Rafiq, Sarwish; Kesarwala, Aparna H; Orthwein, Alexandre; Thomas, Susan N; Khan, Mohammad K; Brandon Dixon, J; Lesinski, Gregory B; Lowe, Michael C; Kissick, Haydn; Yu, David S; Paulos, Chrystal M; Schmitt, Nicole C; Buchwald, Zachary S

CD8+ T cell activation in cancer comprises an initial activation phase in lymph nodes followed by effector differentiation within the tumor

癌症中的 CD8+ T 细胞活化包括淋巴结中的初始活化阶段,随后是肿瘤内的效应细胞分化

Nataliya Prokhnevska, Maria A Cardenas, Rajesh M Valanparambil, Ewelina Sobierajska, Benjamin G Barwick, Caroline Jansen, Adriana Reyes Moon, Petra Gregorova, Luke delBalzo, Rachel Greenwald, Mehmet Asim Bilen, Mehrdad Alemozaffar, Shreyas Joshi, Cara Cimmino, Christian Larsen, Viraj Master, Martin

Immune niches in brain metastases contain TCF1+ stem-like T cells, are associated with disease control and are modulated by preoperative SRS

脑转移瘤中的免疫微环境含有TCF1+干细胞样T细胞,与疾病控制相关,并受术前立体定向放射外科手术的调节。

Jansen, Caroline S; Prabhu, Roshan S; Pagadala, Meghana S; Chappa, Prasanthi; Goyal, Subir; Zhou, Chengjing; Neill, Stewart G; Prokhnevska, Nataliya; Cardenas, Maria; Hoang, Kimberly B; Zhong, Jim; Torres, Mylin; Logan, Suzanna; Olson, Jeffrey J; Nduom, Edjah K; Del Balzo, Luke; Patel, Kirtesh; Burri, Stuart H; Asher, Anthony L; Wilkinson, Scott; Lake, Ross; Higgins, Kristin A; Patel, Pretesh; Dhere, Vishal; Sowalsky, Adam G; Khan, Mohammad K; Kissick, Haydn; Buchwald, Zachary S

Clinical outcome following checkpoint therapy in renal cell carcinoma is associated with a burst of activated CD8 T cells in blood

肾细胞癌患者接受免疫检查点抑制剂治疗后的临床结果与血液中活化的CD8 T细胞数量激增有关。

Jennifer Wilkinson Carlisle,Caroline S Jansen,Maria Andrea Cardenas,Ewelina Sobierajska,Adriana Moon Reyes,Rachel Greenwald,Luke Del Balzo,Nataliya Prokhnevska,Omer Kucuk,Bradley C Carthon,Patrick Connor Mullane,Adeboye Osunkoya,Deborah Baumgarten,Fares Hosseinzadeh,Scott Wilkinson,Ross Lake,Adam G Sowalsky,Yuan Liu,Viraj A Master,Mehmet A Bilen,Haydn Kissick

Functional HPV-specific PD-1+ stem-like CD8 T cells in head and neck cancer

头颈癌中的功能性 HPV 特异性 PD-1+ 干细胞样 CD8 T 细胞

Christiane S Eberhardt #, Haydn T Kissick #, Mihir R Patel, Maria A Cardenas, Nataliya Prokhnevska, Rebecca C Obeng, Tahseen H Nasti, Christopher C Griffith, Se Jin Im, Xu Wang, Dong M Shin, Mary Carrington, Zhuo G Chen, John Sidney, Alessandro Sette, Nabil F Saba, Andreas Wieland, Rafi Ahmed