日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

RIN3 mutations impairing binding of the Alzheimer's disease-associated protein BIN1 lead to RAB5 hyperactivation and endosomal pathology.

RIN3 突变会损害阿尔茨海默病相关蛋白 BIN1 的结合,导致 RAB5 过度激活和内体病变。

Maaser-Hecker Anna K, Zellmer Jacob C, Kim Michelle, Bakiasi Grisilda, Maiti Amit K, Curtat Matea P C, Choi Se Hoon, Prokopenko Dmitry, Tanzi Rudolph E, Bhattacharyya Raja

Matching heterogeneous cohorts by projected principal components reveals two novel Alzheimer's disease-associated genes in the Hispanic population

通过预测主成分匹配异质性队列,揭示了西班牙裔人群中两个新的阿尔茨海默病相关基因

Willett, Julian Daniel Sunday; Waqas, Mohamad; Naumenko, Serhiy; Mullin, Kristina; Hecker, Julian; Bertram, Lars; Lange, Christoph; Vlachos, Ioannis; Hide, Winston; Tanzi, Rudolph E; Prokopenko, Dmitry

Intracellular protein GBF1 displays significant associations with amyloid pathology in Alzheimer's disease.

细胞内蛋白GBF1与阿尔茨海默病中的淀粉样蛋白病理有显著关联。

Miller Sean J, Prokopenko Dmitry, Bai Ping, Mondal Prasenjit, Scott Abigael, Zhang Wei, Gomm Ashley, Zhang Siyi, Child Daniel D, Shen Nolan, Ward Joseph, Schulte Scott, Lei Dan, Hafler Brian P, Wang Changning, Tanzi Rudolph E, Zhang Can

Alzheimer's disease-linked ACE variants increase ACE1 catalytic activity and production of angiotensin II.

与阿尔茨海默病相关的 ACE 变体增加 ACE1 催化活性和血管紧张素 II 的产生。

Salvo Miranda A, Cuddy Leah K, Prokopenko Dmitry, Watkins Elyse, Tanzi Rudolph E, Vassar Robert

Large-scale antibody reactome profiling identifies herpesvirus-autoantigen associations underlying chronic diseases

大规模抗体反应组分析揭示了疱疹病毒与自身抗原的关联,而这些关联是慢性疾病的潜在机制。

Lee, Sanghun; Prince, Nicole; Chen, Qingwen; Chen, Xueying; Lu, Junwei; Mendez, Kevin M; Kelly, Rachel S; Hecker, Julian; Prokopenko, Dmitry; McGeachie, Michael J; Sharma, Rinku; Chen, Yulu; Aparicio, Andrea; Guo, Tao; Levy, Ofer; Rattray, Nicholas Jw; Rattray, Zahra; Lange, Christoph; Larman, H Benjamin; Lasky-Su, Jessica A

Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheimer's disease.

兴奋性和抑制性神经元对阿尔茨海默病的分子适应性特征。

Castanho Isabel, Naderi Yeganeh Pourya, Boix Carles A, Morgan Sarah L, Mathys Hansruedi, Prokopenko Dmitry, White Bartholomew, Soto Larisa M, Pegoraro Giulia, Shah Saloni, Ploumakis Athanasios, Kalavros Nikolas, Bennett David A, Lange Christoph, Kim Doo Yeon, Bertram Lars, Tsai Li-Huei, Kellis Manolis, Tanzi Rudolph E, Hide Winston

On the analysis of metabolite quantitative trait loci: Impact of different data transformations and study designs

关于代谢物数量性状位点的分析:不同数据转换和研究设计的影响

Lee, Sanghun; Kelly, Rachel S; Mendez, Kevin M; Prokopenko, Dmitry; Hahn, Georg; Lutz, Sharon M; Celedón, Juan C; Clish, Clary B; Weiss, Scott T; Lange, Christoph; Lasky-Su, Jessica A; Hecker, Julian

Identification of 16 novel Alzheimer's disease loci using multi-ancestry meta-analyses

利用多祖先荟萃分析鉴定出16个新的阿尔茨海默病基因位点

Willett, Julian Daniel Sunday; Waqas, Mohammad; Choi, Younjung; Ngai, Tiffany; Mullin, Kristina; Tanzi, Rudolph E; Prokopenko, Dmitry

A PKCη missense mutation enhances Golgi-localized signaling and is associated with recessively inherited familial Alzheimer's disease.

PKCη错义突变增强了高尔基体定位的信号传导,并且与隐性遗传的家族性阿尔茨海默病有关

Gauron Maria Celeste, Prokopenko Dmitry, Lee Sanghun, Wolfe Sarah A, Hecker Julian, Willett Julian, Waqas Mohammad, Lordén Gema, Yang Yimin, Mayfield Joshua E, Castanho Isabel, Mullin Kristina, Morgan Sarah, Hahn Georg, Demeo Dawn L, Hide Winston, Bertram Lars, Lange Christoph, Newton Alexandra C, Tanzi Rudolph E

Sex differences in the impact of genetic and clinical risk factors for Alzheimer's disease in midlife

中年时期阿尔茨海默病遗传和临床风险因素影响的性别差异

Konishi, Kyoko; Spets, Dylan S; Fisher, Paris; Aroner, Sarah; Sant, Sarah M; Prokopenko, Dmitry; Lokhande, Hrishikesh; Patel, Rohit; Aizley, Harlyn; Smith, Brianna; Remington, Anne; Spooner, Emma; Touroutoglou, Alexandra; Rosand, Jonathan; Arnold, Steven; Lee, Hang; Dickerson, Bradford; Tanzi, Rudolph E; Chitnis, Tanuja; Goldstein, Jill M