日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Multiple myeloma long-term survivors exhibit sustained immune alterations decades after first-line therapy

多发性骨髓瘤长期生存者在接受一线治疗数十年后仍表现出持续的免疫改变。

Raphael Lutz #,Florian Grünschläger #,Malte Simon #,Mohamed H S Awwad,Marcus Bauer,Schayan Yousefian,Niklas Beumer,Lea Jopp-Saile,Anastasia Sedlmeier,Llorenç Solé-Boldo,Bogdan Avanesyan,Dominik Vonficht,Patrick Stelmach,Georg Steinbuss,Tobias Boch,Simon Steiger,Marc-Andrea Baertsch,Nina Prokoph,Karsten Rippe,Brian G M Durie,Claudia Wickenhauser,Andreas Trumpp,Carsten Müller-Tidow,Daniel Hübschmann,Niels Weinhold,Marc S Raab,Benedikt Brors,Hartmut Goldschmidt,Charles D Imbusch,Michael Hundemer,Simon Haas

Targeting NRAS via miR-1304-5p or farnesyltransferase inhibition confers sensitivity to ALK inhibitors in ALK-mutant neuroblastoma

通过 miR-1304-5p 或法尼基转移酶抑制靶向 NRAS 可使 ALK 突变型神经母细胞瘤对 ALK 抑制剂敏感。

Perla Pucci ,Liam C Lee ,Miaojun Han ,Jamie D Matthews ,Leila Jahangiri ,Michaela Schlederer ,Eleanor Manners ,Annabel Sorby-Adams ,Joshua Kaggie ,Ricky M Trigg ,Christopher Steel ,Lucy Hare ,Emily R James ,Nina Prokoph ,Stephen P Ducray ,Olaf Merkel ,Firkret Rifatbegovic ,Ji Luo ,Sabine Taschner-Mandl ,Lukas Kenner ,G A Amos Burke ,Suzanne D Turner

Resolving therapy resistance mechanisms in multiple myeloma by multiomics subclone analysis

利用多组学亚克隆分析解析多发性骨髓瘤的治疗耐药机制

Poos, Alexandra M; Prokoph, Nina; Przybilla, Moritz J; Mallm, Jan-Philipp; Steiger, Simon; Seufert, Isabelle; John, Lukas; Tirier, Stephan M; Bauer, Katharina; Baumann, Anja; Rohleder, Jennifer; Munawar, Umair; Rasche, Leo; Kortüm, K Martin; Giesen, Nicola; Reichert, Philipp; Huhn, Stefanie; Müller-Tidow, Carsten; Goldschmidt, Hartmut; Stegle, Oliver; Raab, Marc S; Rippe, Karsten; Weinhold, Niels

Targeting CCR7-PI3Kγ overcomes resistance to tyrosine kinase inhibitors in ALK-rearranged lymphoma

靶向 CCR7-PI3Kγ 可克服 ALK 重排淋巴瘤对酪氨酸激酶抑制剂的耐药性

Cristina Mastini, Marco Campisi, Enrico Patrucco, Giulia Mura, Antonio Ferreira, Carlotta Costa, Chiara Ambrogio, Giulia Germena, Cinzia Martinengo, Silvia Peola, Ines Mota, Elena Vissio, Luca Molinaro, Maddalena Arigoni, Martina Olivero, Raffaele Calogero, Nina Prokoph, Fabrizio Tabbò, Brent Shoji,

Resolving the spatial architecture of myeloma and its microenvironment at the single-cell level

在单细胞水平上解析骨髓瘤的空间结构及其微环境

Lukas John #, Alexandra M Poos #, Alexander Brobeil, Carolina Schinke, Stefanie Huhn, Nina Prokoph, Raphael Lutz, Barbara Wagner, Maurizio Zangari, Stephan M Tirier, Jan-Philipp Mallm, Sabrina Schumacher, Dominik Vonficht, Llorenç Solé-Boldo, Sabine Quick, Simon Steiger, Moritz J Przybilla, Katharin

Patient-derived xenograft models of ALK+ ALCL reveal preclinical promise for therapy with brigatinib

ALK+ ALCL 患者来源的异种移植模型显示,布加替尼治疗具有临床前前景

Prokoph, Nina; Matthews, Jamie D; Trigg, Ricky M; Montes-Mojarro, Ivonne A; Burke, G A Amos; Fend, Falko; Merkel, Olaf; Kenner, Lukas; Geoerger, Birgit; Johnston, Robert; Murray, Matthew J; Riguad, Charlotte; Brugières, Laurence; Turner, Suzanne D

Tyrosine phosphatases regulate resistance to ALK inhibitors in ALK+ anaplastic large cell lymphoma

酪氨酸磷酸酶调节 ALK+ 间变性大细胞淋巴瘤对 ALK 抑制剂的耐药性

Elif Karaca Atabay, Carmen Mecca, Qi Wang, Chiara Ambrogio, Ines Mota, Nina Prokoph, Giulia Mura, Cinzia Martinengo, Enrico Patrucco, Giulia Leonardi, Jessica Hossa, Achille Pich, Luca Mologni, Carlo Gambacorti-Passerini, Laurence Brugières, Birgit Geoerger, Suzanne D Turner, Claudia Voena, Taek-Chi

Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma

基于超级增强子的 BATF3/IL-2R 模块识别揭示了间变性大细胞淋巴瘤的脆弱性

Huan-Chang Liang, Mariantonia Costanza, Nicole Prutsch, Mark W Zimmerman, Elisabeth Gurnhofer, Ivonne A Montes-Mojarro, Brian J Abraham, Nina Prokoph, Stefan Stoiber, Simone Tangermann, Cosimo Lobello, Jan Oppelt, Ioannis Anagnostopoulos, Thomas Hielscher, Shahid Pervez, Wolfram Klapper, Francesca Z

STAT3 and TP53 mutations associate with poor prognosis in anaplastic large cell lymphoma

STAT3 和 TP53 突变与间变性大细胞淋巴瘤预后不良相关

Lobello, Cosimo; Tichy, Boris; Bystry, Vojtech; Radova, Lenka; Filip, Daniel; Mraz, Marek; Montes-Mojarro, Ivonne-Aidee; Prokoph, Nina; Larose, Hugo; Liang, Huan-Chang; Sharma, Geeta G; Mologni, Luca; Belada, David; Kamaradova, Katerina; Fend, Falko; Gambacorti-Passerini, Carlo; Merkel, Olaf; Turner, Suzanne D; Janikova, Andrea; Pospisilova, Sarka

Whole Exome Sequencing reveals NOTCH1 mutations in anaplastic large cell lymphoma and points to Notch both as a key pathway and a potential therapeutic target

全外显子组测序揭示了间变性大细胞淋巴瘤中的 NOTCH1 突变,并指出 Notch 既是关键通路,也是潜在的治疗靶点

Hugo Larose, Nina Prokoph, Jamie D Matthews, Michaela Schlederer, Sandra Högler, Ali F Alsulami, Stephen P Ducray, Edem Nuglozeh, Feroze M S Fazaludeen, Ahmed Elmouna, Monica Ceccon, Luca Mologni, Carlo Gambacorti-Passerini, Gerald Hoefler, Cosimo Lobello, Sarka Pospisilova, Andrea Janikova, Wilhelm