日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural determinants for GPCR-mediated inhibition of TASK K2P channels by diacylglycerol and its dysfunction in disease

二酰甘油通过GPCR介导抑制TASK K2P通道的结构决定因素及其在疾病中的功能障碍

Jouen-Tachoire, Thibault R H; Proks, Peter; Seiferth, David; Crowther, Kate; Biggin, Philip C; Baukrowitz, Thomas; Schewe, Marcus; Tucker, Stephen J

Cryo-EM structure of the human THIK-1 K2P K(+) channel reveals a lower Y gate regulated by lipids and anesthetics

人THIK-1 K2P K(+)通道的冷冻电镜结构揭示了一个受脂质和麻醉剂调控的较低Y门控

Rödström, Karin E J; Eymsh, Bisher; Proks, Peter; Hayre, Mehtab S; Cordeiro, Sönke; Mendez-Otalvaro, Edward; Madry, Christian; Rowland, Anna; Kopec, Wojciech; Newstead, Simon; Baukrowitz, Thomas; Schewe, Marcus; Tucker, Stephen J

Structures of TASK-1 and TASK-3 K2P channels provide insight into their gating and dysfunction in disease.

TASK-1 和 TASK-3 K2P 通道的结构揭示了它们在疾病中的门控和功能障碍

Hall Peter Rory, Jouen-Tachoire Thibault, Schewe Marcus, Proks Peter, Baukrowitz Thomas, Carpenter Elisabeth P, Newstead Simon, Rödström Karin E J, Tucker Stephen J

Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation

利用纳米抗体对TREK-2活性进行细胞外调控,有助于深入了解K2P通道调控机制。

Rödström, Karin E J; Cloake, Alexander; Sörmann, Janina; Baronina, Agnese; Smith, Kathryn H M; Pike, Ashley C W; Ang, Jackie; Proks, Peter; Schewe, Marcus; Holland-Kaye, Ingelise; Bushell, Simon R; Elliott, Jenna; Pardon, Els; Baukrowitz, Thomas; Owens, Raymond J; Newstead, Simon; Steyaert, Jan; Carpenter, Elisabeth P; Tucker, Stephen J

Gain-of-function mutations in KCNK3 cause a developmental disorder with sleep apnea

KCNK3基因的功能获得性突变会导致一种伴有睡眠呼吸暂停的发育障碍

Sörmann, Janina; Schewe, Marcus; Proks, Peter; Jouen-Tachoire, Thibault; Rao, Shanlin; Riel, Elena B; Agre, Katherine E; Begtrup, Amber; Dean, John; Descartes, Maria; Fischer, Jan; Gardham, Alice; Lahner, Carrie; Mark, Paul R; Muppidi, Srikanth; Pichurin, Pavel N; Porrmann, Joseph; Schallner, Jens; Smith, Kirstin; Straub, Volker; Vasudevan, Pradeep; Willaert, Rebecca; Carpenter, Elisabeth P; Rödström, Karin E J; Hahn, Michael G; Müller, Thomas; Baukrowitz, Thomas; Hurles, Matthew E; Wright, Caroline F; Tucker, Stephen J

Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate

去甲氟西汀通过多种机制抑制TREK-2 K2P通道,包括对选择性过滤器门的独立于状态的影响。

Proks, Peter; Schewe, Marcus; Conrad, Linus J; Rao, Shanlin; Rathje, Kristin; Rödström, Karin E J; Carpenter, Elisabeth P; Baukrowitz, Thomas; Tucker, Stephen J

Evaluating inositol phospholipid interactions with inward rectifier potassium channels and characterising their role in disease

评估肌醇磷脂与内向整流钾通道的相互作用并阐明其在疾病中的作用

Pipatpolkai, Tanadet; Corey, Robin A; Proks, Peter; Ashcroft, Frances M; Stansfeld, Phillip J

Role of the C-terminus of SUR in the differential regulation of β-cell and cardiac K(ATP) channels by MgADP and metabolism

SUR C 端在 MgADP 和代谢对 β 细胞和心脏 K(ATP) 通道差异性调节中的作用

Vedovato, Natascia; Rorsman, Olof; Hennis, Konstantin; Ashcroft, Frances M; Proks, Peter

Binding of sulphonylureas to plasma proteins - A KATP channel perspective

磺酰脲类药物与血浆蛋白的结合——KATP通道视角

Proks, Peter; Kramer, Holger; Haythorne, Elizabeth; Ashcroft, Frances M

Neonatal diabetes caused by a homozygous KCNJ11 mutation demonstrates that tiny changes in ATP sensitivity markedly affect diabetes risk

由KCNJ11纯合突变引起的新生儿糖尿病表明,ATP敏感性的微小变化会显著影响糖尿病风险。

Vedovato, Natascia; Cliff, Edward; Proks, Peter; Poovazhagi, Varadarajan; Flanagan, Sarah E; Ellard, Sian; Hattersley, Andrew T; Ashcroft, Frances M