日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes

脂化ApoE与受体相互作用的减少可保护机体免受溶酶体中ApoE及其脂质货物致病性的侵害。

Jing L Guo,Dylan Braun,Gabriel A Fitzgerald,Yun-Ting Hsieh,Lionel Rougé,Alexandra Litvinchuk,Micah Steffek,Nicholas E Propson,Catherine M Heffner,Claire Discenza,Suk Ji Han,Anil Rana,Lukas L Skuja,Bi Qi Lin,Elizabeth W Sun,Sonnet S Davis,Srijana Balasundar,Isabel Becerra,Jason C Dugas,Connie Ha,Jennifer Hsiao-Nakamoto,Fen Huang,Shourya Jain,Jennifer E Kung,Nicholas P D Liau,Cathal S Mahon,Hoang N Nguyen,Nathan Nguyen,Madhuja Samaddar,Yajuan Shi,David Tatarakis,Yuxi Tian,Yuda Zhu,Jung H Suh,Thomas Sandmann,Meredith E K Calvert,Annie Arguello,Lesley A Kane,Joseph W Lewcock,David M Holtzman,Christopher M Koth,Gilbert Di Paolo

An integrated photonic engine for programmable atomic control

用于可编程原子控制的集成光子引擎

Christen, Ian; Propson, Thomas; Sutula, Madison; Sattari, Hamed; Choong, Gregory; Panuski, Christopher; Melville, Alexander; Mallek, Justin; Brabec, Cole; Hamilton, Scott; Dixon, P Benjamin; Menssen, Adrian J; Braje, Danielle; Ghadimi, Amir H; Englund, Dirk

Reduction of neuronal activity mediated by blood-vessel regression in the adult brain.

成人大脑中血管退化导致神经元活动减少

Gao Xiaofei, Chen Xing-Jun, Ye Meng, Li Jun-Liszt, Lu Nannan, Yao Di, Ci Bo, Chen Fei, Zheng Lijun, Yi Yating, Zhang Shiwen, Bi Zhanying, Gao Xinwei, Yue Yuanlei, Li Tingbo, Lin Jiafu, Shi Ying-Chao, Shi Kaibin, Propson Nicholas E, Huang Yubin, Poinsatte Katherine, Zhang Zhaohuan, Bosco Dale B, Yang Shi-Bing, Adams Ralf H, Lindner Volkhard, Huang Fen, Wu Long-Jun, Zheng Hui, Hippenmeyer Simon, Stowe Ann M, Peng Bo, Margeta Marta, Guo Qingchun, Wang Xiaoqun, Liu Qiang, Körbelin Jakob, Trepel Martin, Lu Hui, Cai Guoen, Zhou Bo O, Shen Bo, Lu Ying-Mei, Sun Wenzhi, Jia Jie-Min, Han Feng, Zhao Hu, Bachoo Robert M, Ge Woo-Ping

LRRK2 kinase activity regulates Parkinson's disease-relevant lipids at the lysosome

LRRK2激酶活性调节溶酶体中与帕金森病相关的脂质

Michael T Maloney # ,Xiang Wang # ,Rajarshi Ghosh ,Shan V Andrews ,Romeo Maciuca ,Shababa T Masoud ,Maayan Agam ,Richard M Caprioli ,Giuseppe Astarita ,Vitaliy V Bondar ,John Chen ,Chi-Lu Chiu ,Sonnet S Davis ,Audrey Cheuk-Nga Ho ,Hoang N Nguyen ,Nicholas E Propson ,Michelle L Reyzer ,Oliver B Davis ,Matthew C Deen ,Sha Zhu ,Gilbert Di Paolo ,David J Vocadlo ,Anthony A Estrada ,Javier de Vicente ,Joseph W Lewcock ,Annie Arguello ,Jung H Suh ,Sarah Huntwork-Rodriguez ,Anastasia G Henry

A Common PD-Risk GBA1 Variant Disrupts LIMP2 Interaction, Impairs Glucocerebrosidase Function, and Drives Lysosomal and Mitochondrial Dysfunction.

常见的帕金森病风险 GBA1 变异会破坏 LIMP2 相互作用,损害葡萄糖脑苷脂酶功能,并导致溶酶体和线粒体功能障碍

Davis Oliver B, Kung Jennifer E, Davis Sonnet S, Ghosh Rajarshi, Andrews Shan V, Gould Neal S, Kluss Jillian H, Thomsen Elliot, Agam Maayan, Coan John P, Maloney Michael T, Nguyen Ann H, Nguyen Hoang N, Propson Nicholas E, Lozano Edwin I, Yuan Tianao, Xa Kaitlin, Sperberg R Andres Parra, Jain Shourya, Lawrence Roger, Ullman Julie C, Balasundar Srijana, Benton H Paul, Petkovic Maja, Qerqez Ahlam N, Wang Xiang, Zhu Sha, Di Paolo Gilbert, Kariolis Mihalis S, Mahon Cathal S, Arguello Annie, Vocadlo David J, Cookson Mark R, Suh Jung H, Rougé Lionel, Henry Anastasia G

A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models

一种带有血脑屏障转运载体的TREM2激活抗体可增强阿尔茨海默病模型中的小胶质细胞代谢。

Bettina van Lengerich # ,Lihong Zhan # ,Dan Xia # ,Darren Chan ,David Joy ,Joshua I Park ,David Tatarakis ,Meredith Calvert ,Selina Hummel ,Steve Lianoglou ,Michelle E Pizzo ,Rachel Prorok ,Elliot Thomsen ,Laura M Bartos ,Philipp Beumers ,Anja Capell ,Sonnet S Davis ,Lis de Weerd ,Jason C Dugas ,Joseph Duque ,Timothy Earr ,Kapil Gadkar ,Tina Giese ,Audrey Gill ,Johannes Gnörich ,Connie Ha ,Malavika Kannuswamy ,Do Jin Kim ,Sebastian T Kunte ,Lea H Kunze ,Diana Lac ,Kendra Lechtenberg ,Amy Wing-Sze Leung ,Chun-Chi Liang ,Isabel Lopez ,Paul McQuade ,Anuja Modi ,Vanessa O Torres ,Hoang N Nguyen ,Ida Pesämaa ,Nicholas Propson ,Marvin Reich ,Yaneth Robles-Colmenares ,Kai Schlepckow ,Luna Slemann ,Hilda Solanoy ,Jung H Suh ,Robert G Thorne ,Chandler Vieira ,Karin Wind-Mark ,Ken Xiong ,Y Joy Yu Zuchero ,Dolo Diaz ,Mark S Dennis ,Fen Huang ,Kimberly Scearce-Levie ,Ryan J Watts ,Christian Haass ,Joseph W Lewcock ,Gilbert Di Paolo ,Matthias Brendel ,Pascal E Sanchez ,Kathryn M Monroe

Complement C3aR depletion reverses HIF-1α-induced metabolic impairment and enhances microglial response to Aβ pathology

补体 C3aR 耗竭可逆转 HIF-1α 诱导的代谢障碍并增强小胶质细胞对 Aβ 病理的反应

Manasee Gedam, Michele M Comerota, Nicholas E Propson, Tao Chen, Feng Jin, Meng C Wang, Hui Zheng

Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques

小胶质细胞和神经细胞中协同的I型干扰素信号传导会促进与β淀粉样蛋白斑块相关的记忆障碍。

Ethan R Roy ,Gabriel Chiu ,Sanming Li ,Nicholas E Propson ,Rupa Kanchi ,Baiping Wang ,Cristian Coarfa ,Hui Zheng ,Wei Cao

Facial myonecrosis following COVID-19

新冠肺炎后面部肌坏死

Zhao, Raymond; Saab, Hadi; Propson, Anthony; Moritani, Toshio; Kim, John

Endothelial C3a receptor mediates vascular inflammation and blood-brain barrier permeability during aging

内皮细胞C3a受体介导衰老过程中的血管炎症和血脑屏障通透性

Nicholas E Propson ,Ethan R Roy ,Alexandra Litvinchuk ,Jörg Köhl ,Hui Zheng