日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The transaminase-ω-amidase pathway senses oxidative stress to control glutamine metabolism and α-ketoglutarate levels in endothelial cells

转氨酶-ω-酰胺酶通路感知氧化应激,从而调控内皮细胞中的谷氨酰胺代谢和α-酮戊二酸水平。

Niklas Herrle #,Pedro F Malacarne #,Timothy Warwick,Alfredo Cabrera-Orefice,Yiheng Chen,Maedeh Gheisari,Souradeep Chatterjee,Matthias S Leisegang,Tamim Sarakpi,Sarah Wionski,Melina Lopez,Carine Kader,Tom Teichmann,Maria-Kyriaki Drekolia,Ina Koch,Marcus Keßler,Sabine Klein,Frank Erhard Uschner,Jonel Trebicka,Steffen Brunst,Ewgenij Proschak,Stefan Günther,Mónica Rosas-Lemus,Nina Baumgarten,Stephan Klatt,Thimoteus Speer,Sofia-Iris Bibli,Marta Segarra,Amparo Acker-Palmer,Julian U G Wagner,Ilka Wittig,Stefanie Dimmeler,Marcel H Schulz,J B Richards,Ralf Gilsbach,Travis T Denton,Ingrid Fleming,Luciana Hannibal,Ralf P Brandes #,Flávia Rezende #

Click. Screen. Degrade. A Miniaturized D2B Workflow for Rapid PROTAC Discovery

点击。屏幕。降级。用于快速 PROTAC 发现的微型化 D2B 工作流程

Mitrović, Marko; Greco, Francesco Aleksy; García, Yiliam Cruz; Lučić, Aleksandar; Hoffmann, Lasse; Chander, Rohit; Schönfeld, Julia; Liebisch, Nick; Sivashanmugam, Saran Aswathaman; Schwalm, Martin Peter; Egner, Markus; Lewandowski, Max; Merk, Daniel; Morasch, Viktoria; Wolf, Elmar; Müller, Susanne; Hanke, Thomas; Proschak, Ewgenij; Hiesinger, Kerstin; Knapp, Stefan

Inactivation of the Phosphatase Activity of Soluble Epoxide Hydrolase Modulates SIRT3 and Attenuates Experimental Pulmonary Hypertension

可溶性环氧化物水解酶磷酸酶活性的失活调节SIRT3并减轻实验性肺动脉高压

Leuillier, Matthieu; Chelgham, Mustapha; Messaoudi, Hind; Tu, Ly; Ménoret, Severine; Thuillet, Raphaël; Groussard, Déborah; Lillich, Felix F; Ottaviani, Mina; Nicol, Lionel; Mulder, Paul; Humbert, Marc; Richard, Vincent; Anegon, Ignacio; Morisseau, Christophe; Proschak, Ewgenij; Guignabert, Christophe; Bellien, Jérémy

Biochemical investigation of LC3/GABARAP-ligand interaction as an important quality measure for LC3/GABARAP-targeting small molecules: addendum to the guidelines (4th edition)

LC3/GABARAP-配体相互作用的生化研究作为LC3/GABARAP靶向小分子药物的重要质量指标:指南补充(第四版)

Schwalm, Martin P; Lenz, Christopher; Saxena, Krishna; Klionsky, Daniel J; Proschak, Ewgenij; Knapp, Stefan

The phosphatase activity of soluble epoxide hydrolase regulates vascular calcification through the metabolism of pyrophosphate anions

可溶性环氧化物水解酶的磷酸酶活性通过焦磷酸根阴离子的代谢来调节血管钙化。

Messaoudi, Hind; Varennes, Olivier; Berg, Elodie; Perzo, Nicolas; Renet, Sylvanie; Chegrani, Ghiles; Duflot, Thomas; Feugray, Guillaume; Lillich, Felix F; Kauffenstein, Gilles; Brunel, Valéry; Six, Isabelle; Mentaverri, Romuald; Richard, Vincent; Anegon, Ignacio; Morisseau, Christophe; Kamel, Saïd; Proschak, Ewgenij; Bellien, Jérémy

The endocannabinoid anandamide mediates anti-inflammatory effects through activation of NR4A nuclear receptors.

内源性大麻素花生四烯酸乙醇胺通过激活 NR4A 核受体发挥抗炎作用

Teichmann Tom, Pflüger-Müller Beatrice, Giménez Virna Margarita Martín, Sailer Fiona, Dirks Henrik, Zehr Simonida, Warwick Timothy, Brettner Felix, Munoz-Tello Paola, Zimmer Andreas, Tegeder Irmgard, Thomas Dominique, Gurke Robert, Günther Stefan, Heering Jan, Proschak Ewgenij, Geisslinger Gerd, Bibli Iris-S, Heringdorf Dagmar Meyer Zu, Manucha Walter, Windbergs Maike, Knapp Stefan, Weigert Andreas, Leisegang Matthias S, Kojetin Douglas, Brandes Ralf P

Exploiting the 2-(1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic Acid Scaffold to Generate COXTRANs: A New Class of Dual Cyclooxygenase Inhibitors-Thromboxane Receptor Antagonists

利用 2-(1,3,4,9-四氢吡喃并[3,4-b]吲哚-1-基)乙酸骨架生成 COXTRANs:一类新型双重环氧合酶抑制剂-血栓素受体拮抗剂

Blua, Federica; Boccato, Francesca; Buccellati, Carola; Risè, Patrizia; Barbieri, Silvia; Castiglioni, Laura; Balzulat, Annika; Rolando, Barbara; Marini, Elisabetta; Balestra, Marta; Introvigne, Maria Luisa; Giorgis, Marta; Sironi, Luigi; Tacconelli, Stefania; Hiesinger, Kerstin; Patrignani, Paola; Schmidtko, Achim; Steinhilber, Dieter; Proschak, Ewgenij; Sala, Angelo; Rovati, G Enrico; Bertinaria, Massimo

Structure-Based Design of PROTACS for the Degradation of Soluble Epoxide Hydrolase.

基于结构的PROTACS设计用于降解可溶性环氧化物水解酶

Schönfeld Julia, Brunst Steffen, Ciomirtan Ludmila, Willmer Lena, Chromik Michel A, Kumar Adarsh, Froemel Timo, Liebisch Nick, Hackspacher Arne, Ehrler Johanna H M, Wintermeier Lukas, Hesse Christina, Fiedler Jan, Heering Jan, Freitag Hinrich, Zardo Patrick, Fieguth Hans-Gerd, Brüggerhoff Astrid, Jakob Josefine, Häupl Björn, Weizel Lilia, Kaiser Astrid, Schubert-Zsilavecz Manfred, Oellerich Thomas, Fleming Ingrid, Schebb Nils H, Fürst Robert, Kannt Aimo, Knapp Stefan, Proschak Ewgenij, Hiesinger Kerstin

Sustainable Joullié-Ugi and Continuous Flow Implementation Led to Novel Captopril-Inspired Broad-Spectrum Metallo-β-Lactamase Inhibitors.

可持续的 Joullié-Ugi 和连续流实施产生了新型的受卡托普利启发的广谱金属β-内酰胺酶抑制剂

Alfano Antonella Ilenia, Pelliccia Sveva, Barone Simona, Cutarella Luigi, Cancade Sacha Michèle Idriss, Baia Valerio, Cassese Emilia, Russomanno Pasquale, Messano Nicolò, Frank Denia, Weizel Lilia, Rotter Marco J, Brunst Steffen, Wichelhaus Thomas A, Proschak Ewgenij, Tedesco Daniele, Mori Mattia, Docquier Jean Denis, Summa Vincenzo, Brindisi Margherita

S1PR4-dependent effects of Etrasimod on primary human myeloid immune cell activation

Etrasimod 对原代人髓系免疫细胞活化的 S1PR4 依赖性效应

Sailer, Fiona K; Palmer, Megan A; Aliraj, Blerina; Heering, Jan; Brockmann, Andreas; Elewa, Mohammed A F; Röhrig, Aissa; Proschak, Ewgenij; Stepniak, Dariusz T; Ramsey, Simeon; Brüne, Bernhard; Weigert, Andreas