日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Parkinson's VPS35[D620N] mutation induces LRRK2-mediated lysosomal association of RILPL1 and TMEM55B

帕金森病 VPS35[D620N] 突变诱导 LRRK2 介导的 RILPL1 和 TMEM55B 溶酶体结合

Prosenjit Pal, Matthew Taylor, Pui Yiu Lam, Francesca Tonelli, Chloe A Hecht, Pawel Lis, Raja S Nirujogi, Toan K Phung, Wondwossen M Yeshaw, Ebsy Jaimon, Rotimi Fasimoye, Emily A Dickie, Melanie Wightman, Thomas Macartney, Suzanne R Pfeffer, Dario R Alessi

Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms

解读 LRRK 密码:LRRK1 和 LRRK2 磷酸化不同的 Rab 蛋白,并受多种机制调控

Asad U Malik, Athanasios Karapetsas, Raja S Nirujogi, Sebastian Mathea, Deep Chatterjee, Prosenjit Pal, Pawel Lis, Matthew Taylor, Elena Purlyte, Robert Gourlay, Mark Dorward, Simone Weidlich, Rachel Toth, Nicole K Polinski, Stefan Knapp, Francesca Tonelli, Dario R Alessi

Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2 Phosphorylation of Switch 2

Rab8a 通过 LRRK2 磷酸化 Switch 2 招募 RILPL2 的结构基础

Dieter Waschbüsch, Elena Purlyte, Prosenjit Pal, Emma McGrath, Dario R Alessi, Amir R Khan