日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A dual agonist of farnesoid X receptor (FXR) and the G protein-coupled receptor TGR5, INT-767, reverses age-related kidney disease in mice

法呢醇 X 受体 (FXR) 和 G 蛋白偶联受体 TGR5 的双重激动剂 INT-767 可逆转小鼠与年龄相关的肾脏疾病

Xiaoxin X Wang, Yuhuan Luo, Dong Wang, Luciano Adorini, Mark Pruzanski, Evgenia Dobrinskikh, Moshe Levi

Probing the Binding Site of Bile Acids in TGR5

探测TGR5中胆汁酸的结合位点

Macchiarulo, Antonio; Gioiello, Antimo; Thomas, Charles; Pols, Thijs W H; Nuti, Roberto; Ferrari, Cristina; Giacchè, Nicola; De Franco, Francesca; Pruzanski, Mark; Auwerx, Johan; Schoonjans, Kristina; Pellicciari, Roberto

Bile acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic fatty liver disease

胆汁酸受体激活调节肝单核细胞活性并改善非酒精性脂肪肝疾病

Rachel H McMahan, Xiaoxin X Wang, Lin Ling Cheng, Tibor Krisko, Maxwell Smith, Karim El Kasmi, Mark Pruzanski, Luciano Adorini, Lucy Golden-Mason, Moshe Levi, Hugo R Rosen

Diabetic nephropathy is accelerated by farnesoid X receptor deficiency and inhibited by farnesoid X receptor activation in a type 1 diabetes model

在 1 型糖尿病模型中,法尼醇 X 受体缺陷会加速糖尿病肾病的发生,而法尼醇 X 受体激活则会抑制糖尿病肾病的发生

Xiaoxin X Wang, Tao Jiang, Yan Shen, Yupanqui Caldas, Shinobu Miyazaki-Anzai, Hannah Santamaria, Cydney Urbanek, Nathaniel Solis, Pnina Scherzer, Linda Lewis, Frank J Gonzalez, Luciano Adorini, Mark Pruzanski, Jeffrey B Kopp, Jill W Verlander, Moshe Levi

Functional characterization of the semisynthetic bile acid derivative INT-767, a dual farnesoid X receptor and TGR5 agonist

半合成胆汁酸衍生物INT-767的功能表征,一种双重法尼醇X受体和TGR5激动剂

Rizzo, Giovanni; Passeri, Daniela; De Franco, Francesca; Ciaccioli, Gianmario; Donadio, Loredana; Rizzo, Giorgia; Orlandi, Stefano; Sadeghpour, Bahman; Wang, Xiaoxin X; Jiang, Tao; Levi, Moshe; Pruzanski, Mark; Adorini, Luciano

Coordinate expression of group II phospholipase A2 and the acute-phase proteins haptoglobin (HP) and alpha1-anti-chymotrypsin (ACH) by HepG2 cells

HepG2细胞中II型磷脂酶A2与急性期蛋白触珠蛋白(HP)和α1-抗胰凝乳蛋白酶(ACH)的协同表达

Vadas, P; Grouix, B; Stefanski, E; Wloch, M; Pruzanski, W; Schroeder, J; Gauldie, J

Felty's syndrome. Clinical and serological analysis of 34 cases

费尔蒂综合征。34例病例的临床和血清学分析

Sienknecht, C W; Urowitz, M B; Pruzanski, W; Stein, H B

Synovial fluid examination for the diagnosis of amyloidosis

滑液检查用于诊断淀粉样变性

Gordon, D A; Pruzanski, W; Ogryzlo, M A