Botulinum neurotoxins exploit host digestive proteases to boost their oral toxicity via activating OrfXs/P47
肉毒杆菌神经毒素利用宿主消化蛋白酶,通过激活OrfXs/P47来增强其口服毒性。
期刊:Nature Structural & Molecular Biology
影响因子:10.1
doi:10.1038/s41594-024-01479-0
Gao, Linfeng; Nowakowska, Maria Barbara; Selby, Katja; Przykopanski, Adina; Chen, Baohua; Krüger, Maren; Douillard, François Paul; Lam, Kwok-Ho; Chen, Peng; Huang, Ting; Minton, Nigel Peter; Dorner, Martin Bernhard; Dorner, Brigitte Gertrud; Rummel, Andreas; Lindström, Miia; Jin, Rongsheng