日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A pan-cancer compendium of 1,294 plasma cell-free DNA methylomes and fragmentomes enabling multicancer detection

包含1294个血浆游离DNA甲基化组和片段组的泛癌数据库,可实现多癌种检测。

Zeng, Yong; Abelman, Dor D; Singhawansa, Althaf; Cheng, Nicholas; Fang, Yuanchang; Main, Sasha C; Bell, Emma; Ye, Wenbin; Luo, Ping; Wilson, Samantha L; Stutheit-Zhao, Eric Y; Wong, Derek; Znassi, Nadia; Chen, Kui; Mohanraj, Suluxan; Sanz-Garcia, Enrique; Notta, Faiyaz; Ghanekar, Anand; Awadalla, Philip; Lok, Benjamin H; Hoffman, Michael M; Kim, Raymond H; Zadeh, Gelareh; De Carvalho, Daniel D; Bratman, Scott V; Lupien, Mathieu; Pugh, Trevor J; He, Housheng Hansen

PIKfyve inhibition in MM disrupts autophagy and lysosome function, increasing MHC expression and cholesterol metabolism.

PIKfyve 在 MM 中受到抑制会破坏自噬和溶酶体功能,增加 MHC 表达和胆固醇代谢。

Bonolo de Campos Cecilia, He Ruijuan, Pelino Tessa, Abelman Dor D, Li Zhihua, Lee Daniel K C, Wang Ding Yan, St Paul Michael, Bruce Jeffrey, Simpson Craig D, Wybeng-Groot Leanne, Moran Michael F, Tiedemann Rodger, Pugh Trevor, Mak Tak W, Issakova Olga, Sepetov Nikolai, Trudel Suzanne, Stewart A Keith

Rapidly acquired HIV-1 neutralization breadth in a rhesus V2 apex knockin mouse model after a single bolus immunization

单次注射免疫后,恒河猴V2顶端敲入小鼠模型迅速获得HIV-1中和广度

Ghosh, Amrit Raj; Habib, Rumi; Mishra, Nitesh; Roark, Ryan S; Akauliya, Madhav; Albowaidey, Ali A; Allen, Joel D; Amereh, Khaled; Avillion, Gabriel; Bottermann, Maria; Liang, Bo; Chaudhary, Namit; Callaghan, Sean; Dye, Jonathan; Li, Xuduo; Ellis-Pugh, Jordan R; Roy Chowdhury, Rohan; James, Nicole E; Liu, Xiaotie; Maiorino, Laura; Villavicencio, Paula M; Nedellec, Rebecca; Oberoi, Prabhgun; Sowers, Kirsten J; Park, Younghoon; Prum, Thavaleak; Rodriguez, Linette; Ssozi, Maria; Torres, Jonathan L; Walsh, Agnes A; Warner, John E; Weldon, Stephanie R; Xu, Liling; Wiehe, Kevin; Crispin, Max; Ward, Andrew B; Nair, Usha; Hahn, Beatrice H; Burton, Dennis R; Shapiro, Lawrence; Kwong, Peter D; Irvine, Darrell J; Andrabi, Raiees; Shaw, George M; Batista, Facundo D

Enhancing carbon sinks in China using a spatially-optimized forestation strategy

利用空间优化造林策略增强中国的碳汇能力

Dong, Yanli; Yu, Zhen; Pugh, Thomas; Agathokleous, Evgenios; Zhang, Fangmin; Sitch, Stephen; You, Weibin; Han, Wangya; Olin, Stefan; Liu, Shirong; Zhou, Guoyi; Cabral, Pedro; Sun, Pengsen

Binimetinib and encorafenib for the treatment of advanced solid tumors with non-V600E BRAF mutations: results from the Phase II BEAVER trial

比美替尼和恩科拉非尼治疗携带非V600E BRAF突变的晚期实体瘤:来自II期BEAVER试验的结果

April A N Rose #,Jennifer Maxwell #,Emmanuelle Rousselle #,Chantel L Mukonoweshuro,Islam E Elkholi,Melody Riaud,Marco Biondini,Erica Cianfarano,Isabel Soria-Bretones,Chantal Tobin,Meghan McGuire,Rhoda W Y Law,Andrew J Elia,Ben X Wang,Ian King,Tong Zhang,Trevor J Pugh,Zaid Saeed Kamil,Marcus Butler,Frances A Shepherd,Natasha B Leighl,Albiruni Abdul Razak,Aaron Hansen,Samuel D Saibil,Philippe L Bedard,Peter M Siegel,Lillian L Siu,David W Cescon,Anna Spreafico

Mouse model of atypical DAT deficiency syndrome uncovers dopamine dysfunction associated with parkinsonism and ADHD

非典型DAT缺乏综合征的小鼠模型揭示了与帕金森病和ADHD相关的多巴胺功能障碍

Herborg, Freja; Konrad, Lisa K; Jørgensen, Søren H; Lilja, Jamila H; Delignat-Lavaud, Benoît; Posselt, Leonie P; Pugh, Ciara F; Bach, Sofie A; Ratner, Cecilia F; Awadallah, Nora; Pino, Jose A; Berlin, Frida; Ejdrup, Aske L; Olesen, Mikkel V; Rickhag, Mattias; Holst, Birgitte; Aznar, Susana; Mayer, Felix P; Woldbye, David; Torres, Gonzalo; Trudeau, Louis-Eric; Gether, Ulrik

NRN1 as a therapeutic target for Alzheimer's disease.

NRN1 作为阿尔茨海默病的一种治疗靶点。

Pugh Derian A, Cary Gregory A, Greathouse Kelsey M, Nassour-Caswell Lauren C, Hobby Emma L, Seyfried Nicholas T, Herskowitz Jeremy H

Residual lung abnormality following COVID-19 hospitalisation is characterised by biomarkers of epithelial injury.

新冠肺炎住院治疗后遗留的肺部异常以上皮损伤的生物标志物为特征。

Stewart Iain, Jacob Joseph, Porter Joanna C, Liu Bin, Tatler Amanda L, Gomez Nancy, Pugh Matthew R, John Alison E, Allen Richard J, Blaikley John F, Chaudhuri Nazia, Denneny Emma, Fabbri Laura, George Peter M, Guillen-Guio Beatriz, Gooptu Bibek, Hall Ian P, Ho Ling Pei, Jarrold Ian, Johnson Simon, Jones Mark G, Khan Fasihul, Mehta Puja, Mitchell Jane, Molyneaux Philip L, Pearl John E, Piper Hanley Karen, Platé Manuela, Quinn Valerie, Rivera-Ortega Pilar, Saunders Laura C, Smith David J F, Spears Mark, Spencer Lisa G, Stanel Stefan C, Thompson A A Roger, Walsh Simon, Wild Jim M, Wootton Dan G, Docherty Annemarie B, Gleeson Fergus, Greenhalf William, Harrison Ewen M, Lone Nazir, Quint Jennifer, Maslova Anastasia, Pohl Moritz, Stephens Adam, Young Simon, Singapuri Amisha, Shikotra Aarti, Sereno Marco, Saunders Ruth M, Richardson Matthew, Raman Betty, Poinasamy Krisnah, McAuley Hamish J C, Marks Michael, Leavy Olivia C, Houchen-Wolloff Linzy, Horsley Alex, Harris Victoria C, Greening Neil, Evans Rachael A, Elneima Omer, Chalmers James D, Brightling Christopher E, Chambers Rachel C, Wain Louise V, Jenkins R Gisli

A Computational Pathology Model to Predict Docetaxel Benefit in Localized High-Risk and Metastatic Prostate Cancer

利用计算病理学模型预测多西他赛对局限性高危和转移性前列腺癌的疗效

Medina, Sebastian; Tokuyama, Naoto; Hammouda, Kamal; Pathak, Tilak; Mirtti, Tuomas; Fu, Pingfu; Gupta, Shilpa; Lal, Priti; Sandler, Howard M; Correa, Rohann; Chafe, Susan; Shah, Amit; Efstathiou, Jason A; Hoffman, Karen; Straza, Michael; Hallman, Mark A; Jordan, Richard; Pugh, Stephanie L; Sweeney, Christopher J; Madabhushi, Anant

Broad Utility of Ultrasensitive Analysis of ctDNA Dynamics across Solid Tumors Treated with Immunotherapy

免疫疗法治疗实体瘤中ctDNA动态的超灵敏分析具有广泛的应用前景

Garralda, Elena; Abbott, Charles; Calahorro, Alma; Mirallas, Oriol; Pugh, Jason; Moreno-Cárdenas, Ana Belén; Keough, Kathleen; Galvao, Vladimir; Alonso, Guzman; Olano, Armando Mel; Vieito Villar, María; Oberoi, Arjun; Lostes Bardaji, Julia; Hernando-Calvo, Alberto; Braña, Irene; Pretelli, Giulia; Ortega, Belen; Arenillas, Carlota; Czerniak, Natalia; Navarro, Fábio C P; Li, Bailiang; Pyke, Rachel Marty; Ravi, Neeraja; Zatse, Christina; Grussu, Francesco; Sanz, Marta; Viaplana, Cristina; Raskina, Kira; Jimenez, Jose; Fasani, Roberta; Casbas-Hernandez, Patricia; Oflazoglu, Ezoglin; Hodgson, Darren; Reis-Filho, Jorge; Felip, Enriqueta; Élez, Elena; Muñoz, Eva; Dienstmann, Rodrigo; Tabernero, Josep; Lopez-Perez, Raquel; Nuciforo, Paolo; Chen, Richard O; Boyle, Sean M; Toledo, Rodrigo A