日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of a bifunctional PKMYT1-targeting PROTAC empowered by AI-generation.

利用人工智能生成技术发现双功能PKMYT1靶向PROTAC。

Wang Yazhou, Wang Xiaomin, Liu Tingting, Wang Chao, Meng Qingshuo, Meng Fanye, Yu Jiaojiao, Liu Jinxin, Fan Yaya, Gennert David, Pun Frank W, Aliper Alex, Ren Feng, Zhang Man, Cai Xin, Ding Xiao, Zhavoronkov Alex

Oral ENPP1 inhibitor designed using generative AI as next generation STING modulator for solid tumors.

利用人工智能生成技术设计的口服 ENPP1 抑制剂,作为下一代 STING 调节剂用于治疗实体瘤

Pu Congying, Cui Hui, Yu Huaxing, Cheng Xin, Zhang Man, Qin Luoheng, Ning Zhilin, Zhang Wen, Chen Shan, Qian Yuhang, Wang Feng, Wang Ling, Lin Xiaoxia, Gennert David, Pun Frank W, Ren Feng, Zhavoronkov Alex

AI-aided identification of dual-purpose therapeutic targets PRPF19 and MAPK9 in hepatocellular carcinoma and cellular senescence.

AI辅助识别肝细胞癌和细胞衰老中的双重治疗靶点PRPF19和MAPK9。

Ren Christopher, Leung Geoffrey Ho Duen, Tang Qiuqiong, Zhang Peiran, Ma Yongming, Xin Ying, Lok Sarah Wing Yan, Pun Frank W, Zhavoronkov Alex

AI-Driven Drug Target Screening Platform Identified Oncogene CACNA2D1 Activated by Enhancer Infestation in Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma

人工智能驱动的药物靶点筛选平台鉴定出致癌基因 CACNA2D1 在 Epstein-Barr 病毒相关鼻咽癌中因增强子侵染而被激活

Chung, Dittman Lai-Shun; Leung, Geoffrey Ho Duen; Liu, Songran; Lok, Sarah Wing Yan; Xin, Ying; Xia, Yunfei; Zhavoronkov, Alex; Pun, Frank W; Ng, Wai-Tong; Dai, Wei

Precious2GPT: the combination of multiomics pretrained transformer and conditional diffusion for artificial multi-omics multi-species multi-tissue sample generation

Precious2GPT:结合多组学预训练Transformer和条件扩散算法,用于人工生成多组学、多物种、多组织样本。

Sidorenko, Denis; Pushkov, Stefan; Sakip, Akhmed; Leung, Geoffrey Ho Duen; Lok, Sarah Wing Yan; Urban, Anatoly; Zagirova, Diana; Veviorskiy, Alexander; Tihonova, Nina; Kalashnikov, Aleksandr; Kozlova, Ekaterina; Naumov, Vladimir; Pun, Frank W; Aliper, Alex; Ren, Feng; Zhavoronkov, Alex

AttenhERG: a reliable and interpretable graph neural network framework for predicting hERG channel blockers

AttenhERG:一个可靠且可解释的图神经网络框架,用于预测hERG通道阻滞剂

Yang, Tianbiao; Ding, Xiaoyu; McMichael, Elizabeth; Pun, Frank W; Aliper, Alex; Ren, Feng; Zhavoronkov, Alex; Ding, Xiao

PandaOmics: An AI-Driven Platform for Therapeutic Target and Biomarker Discovery

PandaOmics:一个基于人工智能的治疗靶点和生物标志物发现平台

Kamya, Petrina; Ozerov, Ivan V; Pun, Frank W; Tretina, Kyle; Fokina, Tatyana; Chen, Shan; Naumov, Vladimir; Long, Xi; Lin, Sha; Korzinkin, Mikhail; Polykovskiy, Daniil; Aliper, Alex; Ren, Feng; Zhavoronkov, Alex

Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity

长寿生物技术:连接人工智能、生物标志物、衰老科学和临床应用,实现健康长寿

Lyu, Yu-Xuan; Fu, Qiang; Wilczok, Dominika; Ying, Kejun; King, Aaron; Antebi, Adam; Vojta, Aleksandar; Stolzing, Alexandra; Moskalev, Alexey; Georgievskaya, Anastasia; Maier, Andrea B; Olsen, Andrea; Groth, Anja; Simon, Anna Katharina; Brunet, Anne; Jamil, Aisyah; Kulaga, Anton; Bhatti, Asif; Yaden, Benjamin; Pedersen, Bente Klarlund; Schumacher, Björn; Djordjevic, Boris; Kennedy, Brian; Chen, Chieh; Huang, Christine Yuan; Correll, Christoph U; Murphy, Coleen T; Ewald, Collin Y; Chen, Danica; Valenzano, Dario Riccardo; Sołdacki, Dariusz; Erritzoe, David; Meyer, David; Sinclair, David A; Chini, Eduardo Nunes; Teeling, Emma C; Morgen, Eric; Verdin, Eric; Vernet, Erik; Pinilla, Estefano; Fang, Evandro F; Bischof, Evelyne; Mercken, Evi M; Finger, Fabian; Kuipers, Folkert; Pun, Frank W; Gyülveszi, Gabor; Civiletto, Gabriele; Zmudze, Garri; Blander, Gil; Pincus, Harold A; McClure, Joshua; Kirkland, James L; Peyer, James; Justice, Jamie N; Vijg, Jan; Gruhn, Jennifer R; McLaughlin, Jerry; Mannick, Joan; Passos, João; Baur, Joseph A; Betts-LaCroix, Joe; Sedivy, John M; Speakman, John R; Shlain, Jordan; von Maltzahn, Julia; Andreasson, Katrin I; Moody, Kelsey; Palikaras, Konstantinos; Fortney, Kristen; Niedernhofer, Laura J; Rasmussen, Lene Juel; Veenhoff, Liesbeth M; Melton, Lisa; Ferrucci, Luigi; Quarta, Marco; Koval, Maria; Marinova, Maria; Hamalainen, Mark; Unfried, Maximilian; Ringel, Michael S; Filipovic, Milos; Topors, Mourad; Mitin, Natalia; Roy, Nawal; Pintar, Nika; Barzilai, Nir; Binetti, Paolo; Singh, Parminder; Kohlhaas, Paul; Robbins, Paul D; Rubin, Paul; Fedichev, Peter O; Kamya, Petrina; Muñoz-Canoves, Pura; de Cabo, Rafael; Faragher, Richard G A; Konrad, Rob; Ripa, Roberto; Mansukhani, Robin; Büttner, Sabrina; Wickström, Sara A; Brunemeier, Sebastian; Jakimov, Sergey; Luo, Shan; Rosenzweig-Lipson, Sharon; Tsai, Shih-Yin; Dimmeler, Stefanie; Rando, Thomas A; Peterson, Tim R; Woods, Tina; Wyss-Coray, Tony; Finkel, Toren; Strauss, Tzipora; Gladyshev, Vadim N; Longo, Valter D; Dwaraka, Varun B; Gorbunova, Vera; Acosta-Rodríguez, Victoria A; Sorrentino, Vincenzo; Sebastiano, Vittorio; Li, Wenbin; Suh, Yousin; Zhavoronkov, Alex; Scheibye-Knudsen, Morten; Bakula, Daniela

AlphaFold accelerates artificial intelligence powered drug discovery: efficient discovery of a novel CDK20 small molecule inhibitor

AlphaFold加速人工智能驱动的药物发现:高效发现一种新型CDK20小分子抑制剂

Ren, Feng; Ding, Xiao; Zheng, Min; Korzinkin, Mikhail; Cai, Xin; Zhu, Wei; Mantsyzov, Alexey; Aliper, Alex; Aladinskiy, Vladimir; Cao, Zhongying; Kong, Shanshan; Long, Xi; Man Liu, Bonnie Hei; Liu, Yingtao; Naumov, Vladimir; Shneyderman, Anastasia; Ozerov, Ivan V; Wang, Ju; Pun, Frank W; Polykovskiy, Daniil A; Sun, Chong; Levitt, Michael; Aspuru-Guzik, Alán; Zhavoronkov, Alex

A comprehensive AI-driven analysis of large-scale omic datasets reveals novel dual-purpose targets for the treatment of cancer and aging

利用人工智能对大规模组学数据集进行全面分析,揭示了可用于治疗癌症和衰老的新型双重靶点。

Pun, Frank W; Leung, Geoffrey Ho Duen; Leung, Hoi Wing; Rice, Jared; Schmauck-Medina, Tomas; Lautrup, Sofie; Long, Xi; Liu, Bonnie Hei Man; Wong, Chun Wai; Ozerov, Ivan V; Aliper, Alex; Ren, Feng; Rosenberg, Ari J; Agrawal, Nishant; Izumchenko, Evgeny; Fang, Evandro F; Zhavoronkov, Alex