日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics

同时抑制内吞循环和溶酶体融合使细胞和组织对寡核苷酸疗法敏感

Brendan T Finicle, Kazumi H Eckenstein, Alexey S Revenko, Brooke A Anderson, W Brad Wan, Alison N McCracken, Daniel Gil, David A Fruman, Stephen Hanessian, Punit P Seth, Aimee L Edinger

Backbone Hydrocarbon-Constrained Nucleic Acids Modulate Hybridization Kinetics for RNA

骨架碳氢化合物约束的核酸调节 RNA 的杂交动力学

Tamilselvan Rajasekaran, Graeme C Freestone, Rodrigo Galindo-Murillo, Barbara Lugato, Lorena Rico, Juan C Salinas, Hans Gaus, Michael T Migawa, Eric E Swayze, Thomas E Cheatham 3rd, Stephen Hanessian, Punit P Seth

Differential Uptake of Antisense Oligonucleotides in Mouse Hepatocytes and Macrophages Revealed by Simultaneous Two-Photon Excited Fluorescence and Coherent Raman Imaging

通过同时双光子激发荧光和相干拉曼成像揭示小鼠肝细胞和巨噬细胞对反义寡核苷酸的差异摄取

Prabuddha Mukherjee, Edita Aksamitiene, Aneesh Alex, Jindou Shi, Kajari Bera, Chi Zhang, Darold R Spillman, Marina Marjanovic, Michael Fazio, Punit P Seth, Kendall Frazier, Steve R Hood, Stephen A Boppart

The Combination of Mesyl-Phosphoramidate Inter-Nucleotide Linkages and 2'- O-Methyl in Selected Positions in the Antisense Oligonucleotide Enhances the Performance of RNaseH1 Active PS-ASOs

反义寡核苷酸中选定位置的甲磺酰基磷酰胺核苷酸间键和 2'-O-甲基的组合增强了 RNaseH1 活性 PS-ASO 的性能

Lingdi Zhang, Xue-Hai Liang, Cheryl Li De Hoyos, Michael Migawa, Joshua G Nichols, Graeme Freestone, Jun Tian, Punit P Seth, Stanley T Crooke

Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides

迈向下一代反义寡核苷酸:甲磺酰基磷酰胺修饰可改善间隙体反义寡核苷酸的治疗指数和作用持续时间

Brooke A Anderson, Graeme C Freestone, Audrey Low, Cheryl L De-Hoyos, William J Drury Iii, Michael E Østergaard, Michael T Migawa, Michael Fazio, W Brad Wan, Andres Berdeja, Eli Scandalis, Sebastien A Burel, Timothy A Vickers, Stanley T Crooke, Eric E Swayze, Xuehai Liang, Punit P Seth

Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs

5'-甲基 DNA 的位点特异性结合增强了 gapmer ASO 的治疗特性

Guillermo Vasquez, Graeme C Freestone, W Brad Wan, Audrey Low, Cheryl Li De Hoyos, Jinghua Yu, Thazha P Prakash, Michael E Ǿstergaard, Xue-Hai Liang, Stanley T Crooke, Eric E Swayze, Michael T Migawa, Punit P Seth

High-resolution visualization and quantification of nucleic acid-based therapeutics in cells and tissues using Nanoscale secondary ion mass spectrometry (NanoSIMS)

使用纳米级二次离子质谱 (NanoSIMS) 对细胞和组织中的核酸治疗剂进行高分辨率可视化和量化

Cuiwen He, Michael T Migawa, Kai Chen, Thomas A Weston, Michael Tanowitz, Wenxin Song, Paul Guagliardo, K Swaminathan Iyer, C Frank Bennett, Loren G Fong, Punit P Seth, Stephen G Young, Haibo Jiang

Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides

了解控制 DNA 间隙中硫代磷酸酯手性对间隙聚体反义寡核苷酸效力和安全性的影响

Michael E Østergaard, Cheryl L De Hoyos, W Brad Wan, Wen Shen, Audrey Low, Andres Berdeja, Guillermo Vasquez, Susan Murray, Michael T Migawa, Xue-Hai Liang, Eric E Swayze, Stanley T Crooke, Punit P Seth

Characterization of the interactions of chemically-modified therapeutic nucleic acids with plasma proteins using a fluorescence polarization assay

使用荧光偏振分析法表征化学修饰的治疗性核酸与血浆蛋白的相互作用

Hans J Gaus, Ruchi Gupta, Alfred E Chappell, Michael E Østergaard, Eric E Swayze, Punit P Seth

Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle

脂肪酸结合增强反义寡核苷酸在肌肉中的效力

Thazha P Prakash, Adam E Mullick, Richard G Lee, Jinghua Yu, Steve T Yeh, Audrey Low, Alfred E Chappell, Michael E Østergaard, Sue Murray, Hans J Gaus, Eric E Swayze, Punit P Seth