日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

On the PHLPPside: Emerging roles of PHLPP phosphatases in the heart

PHLPP磷酸酶在心脏中的新兴作用

Lemoine, Kellie A; Fassas, Julianna M; Ohannesian, Shirag H; Purcell, Nicole H

Selective coupling of the S1P(3) receptor subtype to S1P-mediated RhoA activation and cardioprotection.

选择性地将 S1P(3) 受体亚型与 S1P 介导的 RhoA 激活和心脏保护偶联

Yung Bryan S, Brand Cameron S, Xiang Sunny Y, Gray Charles B B, Means Christopher K, Rosen Hugh, Chun Jerold, Purcell Nicole H, Brown Joan Heller, Miyamoto Shigeki

Decline in cellular function of aged mouse c-kit(+) cardiac progenitor cells

老年小鼠c-kit(+)心脏祖细胞的细胞功能下降

Castaldi, Alessandra; Dodia, Ramsinh Mansinh; Orogo, Amabel M; Zambrano, Cristina M; Najor, Rita H; Gustafsson, Åsa B; Heller Brown, Joan; Purcell, Nicole H

Physiological activation of Akt by PHLPP1 deletion protects against pathological hypertrophy

PHLPP1缺失导致Akt生理性激活,从而防止病理性肥大。

Moc, Courtney; Taylor, Amy E; Chesini, Gino P; Zambrano, Cristina M; Barlow, Melissa S; Zhang, Xiaoxue; Gustafsson, Åsa B; Purcell, Nicole H

Ca2+/Calmodulin-dependent protein kinase II δ mediates myocardial ischemia/reperfusion injury through nuclear factor-κB

Ca2+/钙调蛋白依赖性蛋白激酶IIδ通过核因子-κB介导心肌缺血/再灌注损伤

Ling, Haiyun; Gray, Charles B B; Zambon, Alexander C; Grimm, Michael; Gu, Yusu; Dalton, Nancy; Purcell, Nicole H; Peterson, Kirk; Brown, Joan Heller

Collagen XIV is important for growth and structural integrity of the myocardium

胶原蛋白XIV对心肌的生长和结构完整性至关重要。

Tao, Ge; Levay, Agata K; Peacock, Jacqueline D; Huk, Danielle J; Both, Sarah N; Purcell, Nicole H; Pinto, Jose R; Galantowicz, Maarten L; Koch, Manuel; Lucchesi, Pamela A; Birk, David E; Lincoln, Joy

RhoA protects the mouse heart against ischemia/reperfusion injury

RhoA可保护小鼠心脏免受缺血/再灌注损伤。

Xiang, Sunny Yang; Vanhoutte, Davy; Del Re, Dominic P; Purcell, Nicole H; Ling, Haiyun; Banerjee, Indroneal; Bossuyt, Julie; Lang, Richard A; Zheng, Yi; Matkovich, Scot J; Miyamoto, Shigeki; Molkentin, Jeffery D; Dorn, Gerald W 2nd; Brown, Joan Heller

PHLPP-1 negatively regulates Akt activity and survival in the heart

PHLPP-1 负调控心脏中的 Akt 活性和细胞存活。

Miyamoto, Shigeki; Purcell, Nicole H; Smith, Jeffrey M; Gao, Tianyan; Whittaker, Ross; Huang, Katherine; Castillo, Rene; Glembotski, Chris C; Sussman, Mark A; Newton, Alexandra C; Brown, Joan Heller

Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes

细胞外信号调节激酶2与心肌细胞中的LIM结构域蛋白FHL2相互作用并受其负调控。

Purcell, Nicole H; Darwis, Dina; Bueno, Orlando F; Müller, Judith M; Schüle, Roland; Molkentin, Jeffery D