日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer

肝硬化肝脏中的PKD1突变克隆可抑制脂肪性肝炎,且不促进癌症发生。

Min Zhu ,Yunguan Wang ,Tianshi Lu ,Jason Guo ,Lin Li ,Meng-Hsiung Hsieh ,Purva Gopal ,Yi Han ,Naoto Fujiwara ,Darren P Wallace ,Alan S L Yu ,Xiangyi Fang ,Crystal Ransom ,Sara Verschleisser ,David Hsiehchen ,Yujin Hoshida ,Amit G Singal ,Adam Yopp ,Tao Wang ,Hao Zhu

Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease

对体细胞突变克隆的阳性选择可识别代谢性肝病中的适应性通路

Zixi Wang ,Shijia Zhu ,Yuemeng Jia ,Yunguan Wang ,Naoto Kubota ,Naoto Fujiwara ,Ruth Gordillo ,Cheryl Lewis ,Min Zhu ,Tripti Sharma ,Lin Li ,Qiyu Zeng ,Yu-Hsuan Lin ,Meng-Hsiung Hsieh ,Purva Gopal ,Tao Wang ,Matt Hoare ,Peter Campbell ,Yujin Hoshida ,Hao Zhu

In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration

体内 CRISPR 筛选发现 BAZ2 染色质重塑因子是哺乳动物肝脏再生过程中可作为药物靶点的调控因子。

Yuemeng Jia ,Lin Li ,Yu-Hsuan Lin ,Purva Gopal ,Shunli Shen ,Kejin Zhou ,Xueliang Yu ,Tripti Sharma ,Yu Zhang ,Daniel J Siegwart ,Joseph M Ready ,Hao Zhu

Ablating putative Ku70 phosphorylation sites results in defective DNA damage repair and spontaneous induction of hepatocellular carcinoma

消除推定的 Ku70 磷酸化位点会导致 DNA 损伤修复缺陷和肝细胞癌的自发诱导

Janapriya Saha, Jinsung Bae, Shih-Ya Wang, Huiming Lu, Lori J Chappell, Purva Gopal, Anthony J Davis

VEGFR2 activity on myeloid cells mediates immune suppression in the tumor microenvironment

髓系细胞上的VEGFR2活性介导肿瘤微环境中的免疫抑制

Yuqing Zhang ,Huocong Huang ,Morgan Coleman ,Arturas Ziemys ,Purva Gopal ,Syed M Kazmi ,Rolf A Brekken

Assessing the safety of transarterial locoregional delivery of low-density lipoprotein docosahexaenoic acid nanoparticles to the rat liver

评估低密度脂蛋白二十二碳六烯酸纳米颗粒经动脉局部区域输送至大鼠肝脏的安全性

Junjie Li, Diana Canseco, Yuzhu Wang, Gonçalo Vale, Jaideep Chaudhary, Arnida Anwar, Hamid Baniasadi, Noelle S Williams, Purva Gopal, Patrick D Sutphin, Jeffrey G McDonald, William C Putnam, Ian R Corbin

Uncovering Biological Factors That Regulate Hepatocellular Carcinoma Growth Using Patient-Derived Xenograft Assays

利用患者来源的异种移植试验揭示调节肝细胞癌生长的生物因素

Min Zhu, Lin Li, Tianshi Lu, Hyesun Yoo, Ji Zhu, Purva Gopal, Sam C Wang, Matthew R Porembka, Nicole E Rich, Sofia Kagan, Mobolaji Odewole, Veronica Renteria, Akbar K Waljee, Tao Wang, Amit G Singal, Adam C Yopp, Hao Zhu

Paneth cell-derived growth factors support tumorigenesis in the small intestine

潘氏细胞衍生的生长因子支持小肠肿瘤的发生

Qing Chen, Kohei Suzuki, Luis Sifuentes-Dominguez, Naoteru Miyata, Jie Song, Adam Lopez, Petro Starokadomskyy, Purva Gopal, Igor Dozmorov, Shuai Tan, Bujun Ge, Ezra Burstein

Somatic Mutations Increase Hepatic Clonal Fitness and Regeneration in Chronic Liver Disease

体细胞突变可增强慢性肝病中肝脏克隆的适应性和再生能力

Min Zhu ,Tianshi Lu ,Yuemeng Jia ,Xin Luo ,Purva Gopal ,Lin Li ,Mobolaji Odewole ,Veronica Renteria ,Amit G Singal ,Younghoon Jang ,Kai Ge ,Sam C Wang ,Mahsa Sorouri ,Justin R Parekh ,Malcolm P MacConmara ,Adam C Yopp ,Tao Wang ,Hao Zhu

Arid1a Loss Drives Nonalcoholic Steatohepatitis in Mice Through Epigenetic Dysregulation of Hepatic Lipogenesis and Fatty Acid Oxidation

Arid1a 缺失通过肝脏脂肪生成和脂肪酸氧化的表观遗传失调导致小鼠非酒精性脂肪性肝炎

Austin Moore, Linwei Wu, Jen-Chieh Chuang, Xuxu Sun, Xin Luo, Purva Gopal, Lin Li, Cemre Celen, Michael Zimmer, Hao Zhu