日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Value-adaptive clinical trial designs for efficient delivery of publicly funded trials - a discussion of methods, case studies, opportunities and challenges

面向价值的临床试验设计如何高效开展公共资助的临床试验——方法、案例研究、机遇与挑战探讨

Flight, Laura; Brennan, Alan; Chick, Stephen E; Forster, Martin; Julious, Steven; Tharmanathan, Puvan

Standardising management of consent withdrawal and other clinical trial participation changes: The UKCRC Registered Clinical Trials Unit Network's PeRSEVERE project

规范撤回知情同意和其他临床试验参与变更的管理:英国临床试验注册中心网络的 PeRSEVERE 项目

Cragg, William J; Clifton-Hadley, Laura; Dearling, Jeremy; Dutton, Susan J; Gillies, Katie; Hardy, Pollyanna; Hind, Daniel; Holm, Søren; Hood, Kerenza; Kearney, Anna; Lewis, Rebecca; Markham, Sarah; Moreau, Lauren; Pham, Tra My; Roberts, Amanda; Ruddock, Sharon; Sirovica, Mirjana; Sohanpal, Ratna; Tharmanathan, Puvan; Verghis, Rejina

Collagenase injection versus limited fasciectomy surgery to treat Dupuytren's contracture in adult patients in the UK: DISC, a non-inferiority RCT and economic evaluation

胶原酶注射与有限筋膜切除术治疗英国成年杜普伊特伦挛缩症患者的疗效比较:一项非劣效性随机对照试验及经济学评价(DISC)

Dias, Joseph; Tharmanathan, Puvan; Arundel, Catherine; Welch, Charlie; Wu, Qi; Leighton, Paul; Armaou, Maria; Corbacho, Belen; Johnson, Nick; James, Sophie; Cooke, John; Bainbridge, Christopher; Craigen, Michael; Warwick, David; Brady, Samantha; Flett, Lydia; Jones, Judy; Knowlson, Catherine; Watson, Michelle; Keding, Ada; Hewitt, Catherine; Torgerson, David

The performance of a Bayesian value-based sequential clinical trial design in the presence of an equivocal cost-effectiveness signal: evidence from the HERO trial

在成本效益信号不明确的情况下,基于贝叶斯价值的序贯临床试验设计的表现:来自HERO试验的证据

Welch, Charlie; Forster, Martin; Ronaldson, Sarah; Keding, Ada; Corbacho-Martín, Belen; Tharmanathan, Puvan

Biomarker Driven Antifungal Stewardship (BioDriveAFS) in acute leukaemia-a multi-centre randomised controlled trial to assess clinical and cost effectiveness: a study protocol for a randomised controlled trial

生物标志物驱动的抗真菌药物管理(BioDriveAFS)在急性白血病中的应用——一项评估其临床和成本效益的多中心随机对照试验:一项随机对照试验的研究方案

Flett, Lydia; Abdelatif, Radwa; Baz, Sarah Akhtar; Brady, Samantha; Corbacho, Belén; Common, Kate; Cowling, Abbie; Fairhurst, Caroline; Fitzmaurice, Ellie; Gandhi, Shreyans; Hilton, Andrea; Hope, William; Howard, Alex; Laycock, Joanne; Lillie, Patrick; Mitchell, Gemma; Parker, Adwoa; Peel, Mary; Sheard, Laura; Sneddon, Jacqueline; Taynton, Thomas; Tharmanathan, Puvan; Torgerson, David; Wang, Han-I; Allsup, David; Barlow, Gavin

Reverse shoulder arthroplasty versus hemiarthroplasty versus non-surgical treatment for older adults with acute 3- or 4-part fractures of the proximal humerus: study protocol for a randomised controlled trial (PROFHER-2: PROximal Fracture of Humerus Evaluation by Randomisation - Trial Number 2)

反向肩关节置换术、半肩关节置换术和非手术治疗老年急性肱骨近端三部分或四部分骨折患者的疗效比较:一项随机对照试验的研究方案(PROFHER-2:肱骨近端骨折随机评估 - 试验编号 2)

Rangan, Amar; Gwilym, Stephen; Keding, Ada; Corbacho, Belen; Kottam, Lucksy; Arundel, Catherine; Coleman, Elizabeth; DiMascio, Livio; Hewitt, Catherine; Jones, Valerie; Kassam, Jamila; McDaid, Catriona; Mitchell, Natasha; Mott, Andrew; O'Carroll, Grace; Tharmanathan, Puvan; Torgerson, David

Participation in community-based lung cancer screening: the Yorkshire Lung Screening Trial

参与社区肺癌筛查:约克郡肺癌筛查试验

Crosbie, Philip A J; Gabe, Rhian; Simmonds, Irene; Hancock, Neil; Alexandris, Panos; Kennedy, Martyn; Rogerson, Suzanne; Baldwin, David; Booton, Richard; Bradley, Claire; Darby, Mike; Eckert, Claire; Franks, Kevin N; Lindop, Jason; Janes, Sam M; Møller, Henrik; Murray, Rachael L; Neal, Richard D; Quaife, Samantha L; Upperton, Sara; Shinkins, Bethany; Tharmanathan, Puvan; Callister, Matthew E J

Dupuytren's interventions surgery versus collagenase (DISC) trial: study protocol for a pragmatic, two-arm parallel-group, non-inferiority randomised controlled trial

杜普伊特伦挛缩症手术与胶原酶治疗(DISC)试验:一项实用性、双臂平行组、非劣效性随机对照试验的研究方案

Dias, Joseph; Arundel, Catherine; Tharmanathan, Puvan; Keding, Ada; Welch, Charlie; Corbacho, Belen; Armaou, Maria; Leighton, Paul; Bainbridge, Christopher; Craigen, Michael; Flett, Lydia; Gascoyne, Samantha; Hewitt, Catherine; James, Elaine; James, Sophie; Johnson, Nick; Jones, Judy; Knowlson, Catherine; Radia, Priya; Torgerson, David; Warwick, David; Watson, Michelle

Cost-effectiveness of hydroxychloroquine versus placebo for hand osteoarthritis: economic evaluation of the HERO trial

羟氯喹与安慰剂治疗手骨关节炎的成本效益分析:HERO试验的经济评价

Ronaldson, Sarah J; Keding, Ada; Tharmanathan, Puvan; Arundel, Catherine; Kingsbury, Sarah R; Conaghan, Philip G; Torgerson, David J

Anti-tumour activity of a first-in-class agent NUC-1031 in patients with advanced cancer: results of a phase I study

一流药物 NUC-1031 对晚期癌症患者的抗肿瘤活性:I 期研究结果

Sarah P Blagden, Ivana Rizzuto, Puvan Suppiah, Daniel O'Shea, Markand Patel, Laura Spiers, Ajithkumar Sukumaran, Nishat Bharwani, Andrea Rockall, Hani Gabra, Mona El-Bahrawy, Harpreet Wasan, Robert Leonard, Nagy Habib, Essam Ghazaly