日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Novel Class of Orally Bioavailable Phenylglycine-Benzoxaborole Conjugates with Antimalarial Activity and Potentially Novel Mechanism of Action

一种新型口服生物利用度高的苯甘氨酸-苯并硼氧杂环化合物,具有抗疟活性和潜在的新型作用机制

Morake, Mokhitli; Taylor, Dale; Coertzen, Dina; Njoroge, Mathew; Krugmann, Liezl; Leshabane, Meta; da Rocha, Shanté; Qahash, Tarrick; Girling, Gareth; Coyle, Rachael; Lee, Marcus C S; Wittlin, Sergio; Llinás, Manuel; Birkholtz, Lyn-Marie; Basarab, Gregory S; Chibale, Kelly

Functional validation of the Plasmodium falciparum K13 C580Y mutation in recently collected Ethiopian isolates

对近期收集的埃塞俄比亚分离株中恶性疟原虫K13 C580Y突变的功能验证

Mukherjee, Angana; Assefa, Ashenafi Bahita; Turlo, Christopher V; Needham, Lisa Checkley; Shoue, Douglas; Qahash, Tarrick; Belachew, Mahlet; Tadesse, Dagimawie; Kassie, Enirsie; Berihun, Mulu; Brhane, Bokretsion G; Parr, Jonathan B; Ferdig, Michael T; Adane, Sisay; Tesfaye, Adisu; Zuromski, Jenna; Fola, Abebe A; Tasew, Geremew; Tollera, Getachew; Juliano, Jonathan J; Bailey, Jeffrey A

The ATM Kinase Inhibitor AZD0156 Is a Potent Inhibitor of Plasmodium Phosphatidylinositol 4-Kinase (PI4Kβ) and Is an Attractive Candidate for Medicinal Chemistry Optimization Against Malaria

ATM激酶抑制剂AZD0156是疟原虫磷脂酰肌醇4-激酶(PI4Kβ)的强效抑制剂,是抗疟药物化学优化的理想候选药物。

Woodland, John G; Coertzen, Dina; Wicht, Kathryn J; Hidalgo, Virginia Franco; Pasaje, Charisse Flerida A; Godoy, Luiz C; Qahash, Tarrick; Mmonwa, Mmakwena M; Dziwornu, Godwin A; Wambua, Lynn; Harries, Sarah; Korkor, Constance M; Njoroge, Mathew; Krugmann, Liezl; Taylor, Dale; Leshabane, Meta; Langeveld, Henrico; Rabie, Tayla; Reader, Janette; van der Watt, Mariëtte; Venter, Nelius; Erlank, Erica; Aswat, Ayesha S; Koekemoer, Lizette L; Yeo, Tomas; Jeon, Jin H; Fidock, David A; Gamo, Francisco Javier; Wittlin, Sergio; Niles, Jacquin C; Llinas, Manuel; Coulson, Lauren B; Birkholtz, Lyn-Marié; Chibale, Kelly

Optimization of Prodiginines as Single-Dose Curative Antimalarials

优化灵菌红素类药物作为单剂量治愈性抗疟药

Kumar, Amrendra; Li, Yuexin; Zhang, Xiaowei; Gaddam, Mahesh; Caridha, Diana; Madejczyk, Michael S; Jin, Xiannu; Dennis, William E; Chetree, Ravi; Blount, Cameron; DeLuca, Jesse; Vuong, Chau; Kudyba, Karl; Roncal, Norma; Ashraf, Kutub; Lee, Patricia J; Pannone, Kristina; Leed, Susan; Dinh, Hieu T; Mdaki, Kennedy; Navarrete, Kimberly; Charlton, Jordan; Binauhan, Angely J; Qahash, Tarrick; Kibe, Kevin Mugambi; Shoue, Douglas A; Checkley, Lisa; Ferdig, Michael T; Chim-Ong, Anongruk; Cui, Liwang; Orena, Stephen; Byaruhanga, Oswald; Assimwe, Jackson; Tibagambirwa, Innocent; Chithanna, Sivanna; Dodean, Rozalia A; Legac, Jennifer; Kreutzfeld, Oriana; Rosenthal, Philip J; Cooper, Roland A; Reynolds, Kevin A; Roth, Alison; Kelly, Jane X; Kancharla, Papireddy

Measuring growth, resistance, and recovery after artemisinin treatment of Plasmodium falciparum in a single semi-high-throughput assay.

在单次半高通量检测中测量恶性疟原虫经青蒿素治疗后的生长、耐药性和恢复情况

Sievert Mackenzie A C, Qahash Tarrick, Singh Puspendra P, Shoue Douglas A, Checkley Lisa A, Brenneman Katelyn Vendrely, Cassady Zione, Kumar Sudhir, Li Xue, Nosten François H, Anderson Timothy J C, Vaughan Ashley M, Romero-Severson Jeanne, Ferdig Michael T

Collateral hypersensitivity between ZY19489 and piperaquine neutralizes PfCRT-mediated drug efflux and Plasmodium falciparum resistance

ZY19489 与哌喹之间的协同超敏反应可中和 PfCRT 介导的药物外排和恶性疟原虫耐药性。

Okombo, John; Ndiaye, Tolla; Qahash, Tarrick; Moura, Igor M R; Gil-Iturbe, Eva; Hagenah, Laura M; Bridgford, Jessica L; Bonatto, Vinicius; Ward, Kurt E; Yeo, Tomas; Narwal, Sunil K; Orta, Lily V; Anderson, Isla; Dhingra, Satish K; Pasaje, Charisse Flerida A; Park, Heekuk; Kim, Jonathan; Guido, Rafael V C; Angulo-Barturen, Iñigo; Niles, Jacquin C; Mancia, Filippo; Uhlemann, Anne-Catrin; Mok, Sachel; Quick, Matthias; Winzeler, Elizabeth A; Leroy, Didier; Llinás, Manuel; Thathy, Vandana; Fidock, David A

Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology

在提高适应性的选择压力下,额外的 PfCRT 突变会导致哌喹耐药性的丧失和恶性疟原虫生理的改变。

Hagenah, Laura M; Dhingra, Satish K; Small-Saunders, Jennifer L; Qahash, Tarrick; Willems, Andreas; Schindler, Kyra A; Rangel, Gabriel W; Gil-Iturbe, Eva; Kim, Jonathan; Akhundova, Emiliya; Yeo, Tomas; Okombo, John; Mancia, Filippo; Quick, Matthias; Roepe, Paul D; Llinás, Manuel; Fidock, David A

Measuring Growth, Resistance, and Recovery after Artemisinin Treatment of Plasmodium falciparum in a single semi-high-throughput Assay.

在单次半高通量检测中测量青蒿素治疗恶性疟原虫后的生长、耐药性和恢复情况

Sievert Mackenzie A C, Singh Puspendra P, Shoue Douglas A, Checkley Lisa A, Brenneman Katelyn M, Qahash Tarrick, Cassady Zione, Kumar Sudhir, Li Xue, Nosten François H, Anderson Timothy J C, Vaughan Ashley M, Romero-Severson Jeanne, Ferdig Michael T

Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages

哌喹耐药的PfCRT突变对恶性疟原虫无性血液期药物转运、血红蛋白分解代谢和寄生虫生理的影响各不相同。

Okombo, John; Mok, Sachel; Qahash, Tarrick; Yeo, Tomas; Bath, Jade; Orchard, Lindsey M; Owens, Edward; Koo, Imhoi; Albert, Istvan; Llinás, Manuel; Fidock, David A