Qi Ling相关文献与解析，生知库 | 链接生命科学的每一步

SEL1L-HRD1 ER-associated degradation facilitates prohormone convertase 2 maturation and glucagon production in islet Î± cells.

SEL1L-HRD1 ER 相关降解促进胰岛α细胞中前激素转化酶 2 的成熟和胰高血糖素的产生。

Zhu Wenzhen, Pan Linxiu, Cui Xianwei, Russo Anna Chiara, Ray Rohit, Pederson Brent, Wei Xiaoqiong, Lin Liangguang Leo, Torres Mauricio, Hafner Hannah, Gregg Brigid, Shrestha Neha, Liu Chengyang, Naji Ali, Arvan Peter, Sandoval Darleen A, Lindberg Iris, Qi Ling, Reinert Rachel Byerley

细胞生物学

发表日期：2026

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Limiting ER-associated degradation capacity triggers acute and chronic effects on insulin biosynthesis

限制内质网相关降解能力会对胰岛素生物合成产生急性及慢性影响。

期刊:Journal of Clinical Investigation

影响因子:13.6

doi:10.1172/JCI187341

Arunagiri, Anoop; Haataja, Leena; Alam, Maroof; Gleason, Noah F; Mastroianni, Emma; Cheng, Chao-Yin; Bazzi, Sami; Knupp, Jeffrey; Metawea, Ibrahim; Hassan, Anis; Larkin, Dennis; Fang, Deyu; Tsai, Billy; Qi, Ling; Arvan, Peter

免疫/内分泌

发表日期：2026

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Neuronal SEL1L-HRD1 ER-associated degradation is essential for motor function and survival in mice.

神经元 SEL1L-HRD1 内质网相关降解对于小鼠的运动功能和生存至关重要。

期刊:Journal of Clinical Investigation

影响因子:13.6

doi:10.1172/JCI196819

Torres Mauricio, Lu You, Pederson Brent, Wang Hui, Gretzinger Anna, Lin Liangguang L, Hwang Jiwon, Chen Xinxin, Rupp Alan C, Tomlinson Abigail J, Scott Andrew J, Zhao Zhen, Wahl Daniel R, Myers Martin G Jr, Lyssiotis Costas A, Qi Ling

神经科学

发表日期：2026

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Role of Copper Homeostasis and Cuproptosis in Cardiovascular Disease: Molecular Insights and Metabolic Perspectives

铜稳态和铜凋亡在心血管疾病中的作用：分子机制和代谢视角

期刊:International Journal of Biological Sciences

影响因子:10

doi:10.7150/ijbs.126580

Yu, Xianzhe; Yuan, Dou; Wang, Yabo; Wang, Leibo; Zhu, Lingling; An, Qi; Ling, Yunfei

SEL1L-HRD1 ERAD-autophagy interplay maintains mitochondrial homeostasis in brown adipocytes

SEL1L-HRD1 ERAD-自噬相互作用维持棕色脂肪细胞线粒体稳态

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2529914123

Chen, Xinxin; Wang, Siwen; Torres, Mauricio; Hao, Sijie; Sun, Shengyi; Qi, Ling

Functional integrity of the SEL1L-HRD1 complex is critical for endoplasmic reticulum-associated degradation and organismal viability.

SEL1L-HRD1 复合物的功能完整性对于内质网相关降解和生物体生存至关重要。

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2517927123

Zhang Xiawei, Lin Liangguang Leo, Pan Linxiu, Wei Xiaoqiong, Wang Huilun Helen, Li Zexin Jason, Qi Ling

发表日期：2026

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CD30 CAR-T cells in combination with anti-PD-1 camrelizumab in relapsed/refractory CD30(+) lymphomas

CD30 CAR-T细胞联合抗PD-1卡瑞利珠单抗治疗复发/难治性CD30(+)淋巴瘤

期刊:Journal of Translational Medicine

影响因子:7.5

doi:10.1186/s12967-026-07967-9

Yu, Min; Liu, Longzi; Zhou, Xiaoxi; Zhou, Yulan; Xu, Shan; Kong, Fancong; Qi, Ling; Wu, Jing; Zhang, Tongcun; Li, Fei

Efficacy and safety of neoadjuvant immunotherapy in locally advanced resectable esophageal squamous cell carcinoma: a network meta-analysis and real-world study

新辅助免疫疗法治疗局部晚期可切除食管鳞状细胞癌的疗效和安全性：一项网络荟萃分析和真实世界研究

期刊:Frontiers in Immunology

影响因子:5.9

doi:10.3389/fimmu.2026.1764960

Sun, Mengfei; Yang, Pengjie; Qi, Ling; Yang, Ting; Wang, Weishi; Yu, Yongjun; Zhang, Jingjing; Zhu, Benben; Li, Yong

Circ_0003323 binds METTL1 to mediate KLK6 m7G methylation modification and promote the progression of colorectal cancer

Circ_0003323 与 METTL1 结合，介导 KLK6 m7G 甲基化修饰，促进结直肠癌的进展。

期刊:iScience

影响因子:4.1

doi:10.1016/j.isci.2026.114999

Zhang, Mengyang; Li, Wen; Ma, Jiachun; Mu, Hongye; Zhao, Yubo; Qi, Ling; Liu, Donglian; Peng, Tieli

Structural basis and pathological implications of the dimeric OS9-SEL1L-HRD1 ERAD Core Complex.

二聚体 OS9-SEL1L-HRD1 ERAD 核心复合物的结构基础和病理意义。

SEL1L-HRD1 ER-associated degradation facilitates prohormone convertase 2 maturation and glucagon production in islet Î± cells.

SEL1L-HRD1 ER 相关降解促进胰岛α细胞中前激素转化酶 2 的成熟和胰高血糖素的产生。

Limiting ER-associated degradation capacity triggers acute and chronic effects on insulin biosynthesis

限制内质网相关降解能力会对胰岛素生物合成产生急性及慢性影响。

Neuronal SEL1L-HRD1 ER-associated degradation is essential for motor function and survival in mice.

神经元 SEL1L-HRD1 内质网相关降解对于小鼠的运动功能和生存至关重要。

Role of Copper Homeostasis and Cuproptosis in Cardiovascular Disease: Molecular Insights and Metabolic Perspectives

铜稳态和铜凋亡在心血管疾病中的作用：分子机制和代谢视角

SEL1L-HRD1 ERAD-autophagy interplay maintains mitochondrial homeostasis in brown adipocytes

SEL1L-HRD1 ERAD-自噬相互作用维持棕色脂肪细胞线粒体稳态

Functional integrity of the SEL1L-HRD1 complex is critical for endoplasmic reticulum-associated degradation and organismal viability.

SEL1L-HRD1 复合物的功能完整性对于内质网相关降解和生物体生存至关重要。

CD30 CAR-T cells in combination with anti-PD-1 camrelizumab in relapsed/refractory CD30(+) lymphomas

CD30 CAR-T细胞联合抗PD-1卡瑞利珠单抗治疗复发/难治性CD30(+)淋巴瘤

Efficacy and safety of neoadjuvant immunotherapy in locally advanced resectable esophageal squamous cell carcinoma: a network meta-analysis and real-world study

新辅助免疫疗法治疗局部晚期可切除食管鳞状细胞癌的疗效和安全性：一项网络荟萃分析和真实世界研究

Circ_0003323 binds METTL1 to mediate KLK6 m7G methylation modification and promote the progression of colorectal cancer

Circ_0003323 与 METTL1 结合，介导 KLK6 m7G 甲基化修饰，促进结直肠癌的进展。