日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

mTOR-driven integrin β4-enriched extracellular vesicles from lenvatinib-resistant hepatocellular carcinoma fuel lung metastasis via fibroblast-niche formation

来自耐乐伐替尼肝细胞癌的mTOR驱动的富含整合素β4的细胞外囊泡通过成纤维细胞微环境的形成促进肺转移。

期刊:Signal Transduction and Targeted Therapy
影响因子:52.7
doi:10.1038/s41392-026-02625-4
Zou, Tiantian; Wang, Xufeng; Sun, Haoting; Hu, Beiyuan; Li, Jianhua; Guo, Yu; Tian, Zilu; Xu, Hao; Zheng, Yan; Su, Yinghan; Chan, Chak Lam; Zhu, Le; Shen, Keyu; Shen, Xiaotian; Dong, Qiongzhu; Qin, Lun-Xiu
成纤维细胞
肿瘤
mTOR
肿瘤免疫
囊泡
细胞生物学
发表日期：2026
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Oncolytic adenovirus delivery of neoantigens sensitizes low-mutation tumors to anti-PD-1 therapy and prevents metastasis.

利用溶瘤腺病毒递送新抗原可使低突变肿瘤对PD-1抑制剂疗法敏感，并防止转移。

期刊:Signal Transduction and Targeted Therapy
影响因子:52.7
doi:10.1038/s41392-025-02511-5
Shen Ke-Yu, Yu Shi-Zhe, Su Ying-Han, Xie Sun-Zhe, Zhang Chen, Xu Hao, Yang SamI, Zou Tian-Tian, Fu Yan, Wang Hao, Fang Lin, Zheng Yan, Su Chang-Qing, Qin Lun-Xiu
微生物学
肿瘤
肿瘤免疫
PD-1
发表日期：2025
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Comparison of (11)C-Acetate and (18)F-FDG PET/CT for Immune Infiltration and Prognosis in Hepatocellular Carcinoma.

比较 (11)C-乙酸盐和 (18)F-FDG PET/CT 在肝细胞癌免疫浸润和预后中的应用

期刊:Cancer Science
影响因子:4.3
doi:10.1111/cas.16449
Xu Hao, Wang Hao, Jiang Dong-Lang, Wu Yan-Fei, Xie Sun-Zhe, Su Ying-Han, Guan Yi-Hui, Xie Fang, Zhu Wen-Wei, Qin Lun-Xiu
细胞生物学
发表日期：2025
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Immunosuppressive tumor microenvironment and immunotherapy of hepatocellular carcinoma: current status and prospectives

肝细胞癌的免疫抑制性肿瘤微环境及免疫治疗：现状与展望

期刊:Journal of Hematology & Oncology
影响因子:40.4
doi:10.1186/s13045-024-01549-2
Shen, Ke-Yu; Zhu, Ying; Xie, Sun-Zhe; Qin, Lun-Xiu
肿瘤
肿瘤免疫
细胞生物学
肿瘤微环境
免疫/内分泌
发表日期：2024
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Development and validation of a mutation-annotated prognostic score for intrahepatic cholangiocarcinoma after resection: a retrospective cohort study

肝内胆管癌切除术后突变注释预后评分的建立与验证：一项回顾性队列研究

期刊:International Journal of Surgery
影响因子:10.1
doi:10.1097/JS9.0000000000000636
Wang, Xiang-Yu; Zhu, Wen-Wei; Lu, Lu; Li, Yi-Tong; Zhu, Ying; Yang, Lu-Yu; Sun, Hao-Ting; Wang, Chao-Qun; Lin, Jing; Huang, Chong; Yang, Xin; Fan, Jie; Jia, Hu-Liang; Zhang, Ju-Bo; Yin, Bao-Bing; Chen, Jin-Hong; Qin, Lun-Xiu
肿瘤
胆管癌
肿瘤免疫
发表日期：2023
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The combination of PD-1 blockade with interferon-α has a synergistic effect on hepatocellular carcinoma

PD-1阻断剂与干扰素-α联合使用对肝细胞癌具有协同作用

期刊:Cellular & Molecular Immunology
影响因子:19.8
doi:10.1038/s41423-022-00848-3
Zhu, Ying; Chen, Mo; Xu, Da; Li, Tian-En; Zhang, Ze; Li, Jian-Hua; Wang, Xiang-Yu; Yang, Xin; Lu, Lu; Jia, Hu-Liang; Dong, Qiong-Zhu; Qin, Lun-Xiu
细胞生物学
肿瘤
肿瘤免疫
PD-1
发表日期：2022
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Driver mutations of intrahepatic cholangiocarcinoma shape clinically relevant genomic clusters with distinct molecular features and therapeutic vulnerabilities

肝内胆管癌的驱动基因突变形成具有独特分子特征和治疗靶点的临床相关基因组簇。

期刊:Theranostics
影响因子:13.3
doi:10.7150/thno.63417
Wang, Xiang-Yu; Zhu, Wen-Wei; Wang, Zheng; Huang, Jian-Bo; Wang, Sheng-Hao; Bai, Fu-Mao; Li, Tian-En; Zhu, Ying; Zhao, Jing; Yang, Xin; Lu, Lu; Zhang, Ju-Bo; Jia, Hu-Liang; Dong, Qiong-Zhu; Chen, Jin-Hong; Andersen, Jesper B; Ye, Dan; Qin, Lun-Xiu
肿瘤
胆管癌
肿瘤免疫
发表日期：2022
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The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives

胰腺腺癌的分子生物学：转化挑战和临床展望

期刊:Signal Transduction and Targeted Therapy
影响因子:52.7
doi:10.1038/s41392-021-00659-4
Wang, Shun; Zheng, Yan; Yang, Feng; Zhu, Le; Zhu, Xiao-Qiang; Wang, Zhe-Fang; Wu, Xiao-Lin; Zhou, Cheng-Hui; Yan, Jia-Yan; Hu, Bei-Yuan; Kong, Bo; Fu, De-Liang; Bruns, Christiane; Zhao, Yue; Qin, Lun-Xiu; Dong, Qiong-Zhu
肿瘤
肿瘤免疫
发表日期：2021
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GOLM1 exacerbates CD8(+) T cell suppression in hepatocellular carcinoma by promoting exosomal PD-L1 transport into tumor-associated macrophages

GOLM1通过促进外泌体PD-L1转运至肿瘤相关巨噬细胞，加剧肝细胞癌中CD8(+) T细胞的抑制。

期刊:Signal Transduction and Targeted Therapy
影响因子:52.7
doi:10.1038/s41392-021-00784-0
Chen, Jinhong; Lin, Zhifei; Liu, Lu; Zhang, Rui; Geng, Yan; Fan, Minghao; Zhu, Wenwei; Lu, Ming; Lu, Lu; Jia, Huliang; Zhang, Jubo; Qin, Lun-Xiu
巨噬细胞
外泌体
肿瘤
T细胞
肿瘤免疫
巨噬细胞
CD8
PD-L1
T细胞
细胞生物学
免疫/内分泌
发表日期：2021
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Increased neutrophil extracellular traps promote metastasis potential of hepatocellular carcinoma via provoking tumorous inflammatory response

中性粒细胞胞外陷阱增多可通过诱导肿瘤炎症反应促进肝细胞癌的转移潜能。

期刊:Journal of Hematology & Oncology
影响因子:40.4
doi:10.1186/s13045-019-0836-0
Yang, Lu-Yu; Luo, Qin; Lu, Lu; Zhu, Wen-Wei; Sun, Hao-Ting; Wei, Ran; Lin, Zhi-Fei; Wang, Xiang-Yu; Wang, Chao-Qun; Lu, Ming; Jia, Hu-Liang; Chen, Jin-Hong; Zhang, Ju-Bo; Qin, Lun-Xiu
肿瘤
炎症
中性粒细胞
肿瘤免疫
炎症/感染
粒细胞
细胞生物学
发表日期：2020
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