The G9a-TRIM21 axis exacerbates diabetic renal ischemia-reperfusion injury by inducing methylation-dependent ubiquitination and degradation of FoxO3a to promote oxidative stress and pyroptosis.
G9a-TRIM21 轴通过诱导 FoxO3a 的甲基化依赖性泛素化和降解，促进氧化应激和细胞焦亡，从而加剧糖尿病肾脏缺血再灌注损伤。
期刊:Redox Biology
影响因子:11.9
doi:10.1016/j.redox.2025.103964
Zheng Qingyuan, Qin Xuke, Huang Shiyu, Yan Zhiwei, Liu Jin, Xiong Yufeng, Zhao Xiaojie, Ni Xinmiao, Mei Haonan, Jian Jun, Wang Jingsong, Lu Qianxue, Chen Zhiyuan, Liu Xiuheng, Wan Shanshan, Liu Hao, Wang Lei
糖尿病
细胞生物学
FOXO3
FoxO3a
氧化应激
泛素化
焦亡
