Multi-omics analysis of patient-derived organoids reveals that E3 ligase COP1 promotes liver metastasis and oxaliplatin resistance in colorectal cancer through LUZP1 degradation and MYL9 phosphorylation
对患者来源类器官的多组学分析表明,E3连接酶COP1通过LUZP1降解和MYL9磷酸化促进结直肠癌的肝转移和奥沙利铂耐药性。
期刊:Experimental Hematology & Oncology
影响因子:13.5
doi:10.1186/s40164-026-00771-7
Zhang, Ruijia; Luo, Wenqin; Zhou, Qikai; Liang, Dongguo; Hao, Yuankai; Chen, Fan; Qiu, Yulin; Cao, Yixian; Shan, Zezhi; Zhang, Yu; Li, Qingguo; Cai, Sanjun; Luo, Dakui; Mo, Shaobo; Ma, Bin; Li, Xinxiang