日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Human microglia in brain assembloids display region-specific diversity and respond to hyperexcitable neurons carrying SCN2A mutation.

脑集合体中的人类小胶质细胞表现出区域特异性多样性,并对携带 SCN2A 突变的过度兴奋神经元做出反应。

Wu Jiaxiang, Chen Xiaoling, Zhang Jingliang, Wettschurack Kyle, Robinson Morgan, Li Weihao, Zhao Yuanrui, Yoo Ye-Eun, Deming Brody A, Shu Yue, Abeyaratna Akila D, Que Zhefu, Du Dongshu, Tegtmeyer Matthew, Yuan Chongli, Skarnes William C, Zhang Zhong-Yin, Rochet Jean-Christophe, Wu Long-Jun, Yang Yang

Epilepsy-Associated SCN2A-L1342P Mutation Drives Network Hyperexcitability and Widespread Transcriptomic Changes in Human Cortical Organoids

癫痫相关的SCN2A-L1342P突变驱动人类皮质类器官网络过度兴奋和广泛的转录组变化

Olivero-Acosta, Maria I; Robinson, Morgan; Que, Zhefu; Zhang, Zaiyang; Harlow, Hope Elizabeth; Shankar, Vinayak; Hong, Seoyong; Wang, Muhan; Otterbacher, Conrad M; Kadono, Hina; Halurkar, Manasi; Kothandaraman, Harish; Lanman, Nadia; Nguyen, Trang; Wettschurack, Kyle; Zirkle, Benjamin; Yunis, Layan; Cui, Ningren; Chen, Xiaoling; Zhang, Jingliang; Wu, Jiaxiang; Skarnes, William C; Yuan, Chongli; Guo, Feng; Yang, Yang

Human microglia in brain assembloids display region-specific diversity and respond to hyperexcitable neurons carrying SCN2A mutation: Microglial diversity and response in assembloids.

脑集合体中的人类小胶质细胞表现出区域特异性多样性,并对携带 SCN2A 突变的过度兴奋神经元做出反应:集合体中的小胶质细胞多样性和反应

Wu Jiaxiang, Chen Xiaoling, Zhang Jingliang, Wettschurack Kyle, Robinson Morgan, Li Weihao, Zhao Yuanrui, Yoo Ye-Eun, Deming Brody A, Abeyaratna Akila D, Que Zhefu, Du Dongshu, Tegtmeyer Matthew, Yuan Chongli, Skarnes William C, Rochet Jean-Christophe, Wu Long-Jun, Yang Yang

Restoration of excitation/inhibition balance enhances neuronal signal-to-noise ratio and rescues social deficits in autism-associated Scn2a-deficiency.

恢复兴奋/抑制平衡可提高神经元信噪比,并挽救自闭症相关 Scn2a 缺陷引起的社交缺陷

Zhang Jingliang, Eaton Muriel, Chen Xiaoling, Zhao Yuanrui, Kant Shivam, Deming Brody A, Harish Kothandaraman, Nguyen Huynhvi P, Shu Yue, Lai Shirong, Wu Jiaxiang, Que Zhefu, Wettschurack Kyle W, Zhang Zaiyang, Xiao Tiange, Halurkar Manasi S, Olivero-Acosta Maria I, Yoo Ye-Eun, Lanman Nadia A, Koss Wendy A, Skarnes William C, Yang Yang

Autism-associated SCN2A deficiency disrupts cortico-striatal circuitry in human brain assembloids.

与自闭症相关的 SCN2A 缺陷会破坏人类大脑组装体中的皮质纹状体回路

Chen Xiaoling, Zhang Jingliang, Wu Jiaxiang, Robinson Morgan J, Kothandaraman Harish, Yoo Ye-Eun, Dopeso-Reyes Iria M Gonzalez, Buffenoir Thomas D, Halurkar Manasi S, Zhang Zaiyang, Wang Muhan, Creager Erin N, Zhao Yuanrui, Olivero-Acosta Maria I, Wettschurack Kyle W, Que Zhefu, Yuan Chongli, Schaser Allison J, Lanman Nadia A, Rochet Jean-Christophe, Skarnes William C, Kremer Eric J, Yang Yang

Human iPSC-derived microglia sense and dampen hyperexcitability of cortical neurons carrying the epilepsy-associated SCN2A-L1342P mutation.

人类 iPSC 衍生的小胶质细胞能够感知并抑制携带癫痫相关 SCN2A-L1342P 突变的皮层神经元的过度兴奋

Que Zhefu, Olivero-Acosta Maria I, Robinson Morgan, Chen Ian, Zhang Jingliang, Wettschurack Kyle, Wu Jiaxiang, Xiao Tiange, Otterbacher C Max, Shankar Vinayak, Harlow Hope, Hong Seoyong, Zirkle Benjamin, Wang Muhan, Cui Ningren, Mandal Purba, Chen Xiaoling, Deming Brody, Halurkar Manasi, Zhao Yuanrui, Rochet Jean-Christophe, Xu Ranjie, Brewster Amy L, Wu Long-Jun, Yuan Chongli, Skarnes William C, Yang Yang