日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Potent Dual BET Bromodomain-Kinase Inhibitors as Value-Added Multitargeted Chemical Probes and Cancer Therapeutics

强效双 BET 溴结构域激酶抑制剂可作为增值多靶点化学探针和癌症治疗剂

Stuart W Ember, Que T Lambert, Norbert Berndt, Steven Gunawan, Muhammad Ayaz, Marilena Tauro, Jin-Yi Zhu, Paula J Cranfill, Patricia Greninger, Conor C Lynch, Cyril H Benes, Harshani R Lawrence, Gary W Reuther, Nicholas J Lawrence, Ernst Schönbrunn

The PIM inhibitor AZD1208 synergizes with ruxolitinib to induce apoptosis of ruxolitinib sensitive and resistant JAK2-V617F-driven cells and inhibit colony formation of primary MPN cells

PIM 抑制剂 AZD1208 与芦可替尼协同作用,诱导芦可替尼敏感和耐药的 JAK2-V617F 驱动细胞凋亡,并抑制原发性 MPN 细胞集落形成

Lucia Mazzacurati, Que T Lambert, Anuradha Pradhan, Lori N Griner, Dennis Huszar, Gary W Reuther

Mutations in the transmembrane and juxtamembrane domains enhance IL27R transforming activity

跨膜和近膜结构域的突变增强了 IL27R 转化活性

Que T Lambert, Anuradha Pradhan, J Devon Roll, Gary W Reuther

Transforming JAK1 mutations exhibit differential signalling, FERM domain requirements and growth responses to interferon-γ

转化 JAK1 突变表现出不同的信号传导、FERM 结构域要求和对干扰素-γ 的生长反应

Geoff M Gordon, Que T Lambert, Kenyon G Daniel, Gary W Reuther

Activation of JAK2-V617F by components of heterodimeric cytokine receptors

异二聚细胞因子受体成分激活JAK2-V617F

Anuradha Pradhan, Que T Lambert, Lori N Griner, Gary W Reuther