Pathway Of Low Anterior Resection syndrome (LARS) relief after Surgery (POLARiS): protocol for an international, open-label, multi-arm, phase 3 randomised superiority trial within a cohort, with economic evaluation, process evaluation and qualitative sub-study, to explore the natural history of LARS and compare transanal irrigation and sacral neuromodulation to optimised conservative management for people with major LARS following a high or low anterior resection for colorectal cancer
低位直肠癌前切除术后综合征（LARS）缓解路径（POLARiS）：一项国际性、开放标签、多臂、3期随机队列优效性试验方案，包含经济评价、过程评价和定性子研究，旨在探索LARS的自然病程，并将经肛门灌洗和骶神经调节与优化的保守治疗方案进行比较，用于治疗接受高位或低位直肠癌前切除术后出现严重LARS的患者。
期刊:BMJ Open
影响因子:2.3
doi:10.1136/bmjopen-2024-092612
Croft, Julie; Farrow, Emily; Coxon-Meggy, Alexandra Harriet; Gordon, Katie; Corrigan, Neil; Mather, Hannah; Stocken, Deborah D; Dale, Megan; Chong, Huey Yi; White, Judith; Knight, Laura; Meggy, Alun; Lloydwin, Christina; Tan, Betty; Douglas, Ashley; Powell, Ralph; Hepburn, Julie; Jayne, David; Torkington, Jared; Warwick, Andrea; Ng, Kheng-Seong; Wilson, Kate; Knowles, Charles H; Quyn, Aaron; Cornish, Julie
