R Benjamin Free相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

G Protein-Coupled Receptor Kinase 2 Selectively Enhances β-Arrestin Recruitment to the D2 Dopamine Receptor through Mechanisms That Are Independent of Receptor Phosphorylation

蛋白偶联受体激酶 2 通过不依赖受体磷酸化的机制选择性增强 β-Arrestin 对 D2 多巴胺受体的募集

期刊:Biomolecules

影响因子:4.8

doi:10.3390/biom13101552

Marta Sánchez-Soto, Noelia M Boldizsar, Kayla A Schardien, Nora S Madaras, Blair K A Willette, Laura R Inbody, Christopher Dasaro, Amy E Moritz, Julia Drube, Raphael S Haider, R Benjamin Free, Carsten Hoffman, David R Sibley

发表日期：2023

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Identification and Characterization of ML321: A Novel and Highly Selective D2 Dopamine Receptor Antagonist with Efficacy in Animal Models That Predict Atypical Antipsychotic Activity

ML321 的鉴别和表征：一种新型高选择性 D2 多巴胺受体拮抗剂，在预测非典型抗精神病活性的动物模型中具有疗效

期刊:ACS Pharmacology & Translational Science

影响因子:4.9

doi:10.1021/acsptsci.2c00202

R Benjamin Free, Ashley N Nilson, Noelia M Boldizsar, Trevor B Doyle, Ramona M Rodriguiz, Vladimir M Pogorelov, Mayako Machino, Kuo Hao Lee, Jeremiah W Bertz, Jinbin Xu, Herman D Lim, Andrés E Dulcey, Robert H Mach, James H Woods, J Robert Lane, Lei Shi, Juan J Marugan, William C Wetsel, David R Sib

发表日期：2022

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Dual pancreatic adrenergic and dopaminergic signaling as a therapeutic target of bromocriptine

胰腺肾上腺素能和多巴胺能双重信号作为溴隐亭的治疗靶点

期刊:iScience

影响因子:4.6

doi:10.1016/j.isci.2022.104771

Despoina Aslanoglou, Suzanne Bertera, Laura Friggeri, Marta Sánchez-Soto, Jeongkyung Lee, Xiangning Xue, Ryan W Logan, J Robert Lane, Vijay K Yechoor, Peter J McCormick, Jens Meiler, R Benjamin Free, David R Sibley, Rita Bottino, Zachary Freyberg

发表日期：2022

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Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors

多巴胺通过肾上腺素能和多巴胺能受体调节胰腺胰高血糖素和胰岛素的分泌

期刊:Translational Psychiatry

影响因子:5.8

doi:10.1038/s41398-020-01171-z

Despoina Aslanoglou, Suzanne Bertera, Marta Sánchez-Soto, R Benjamin Free, Jeongkyung Lee, Wei Zong, Xiangning Xue, Shristi Shrestha, Marcela Brissova, Ryan W Logan, Claes B Wollheim, Massimo Trucco, Vijay K Yechoor, David R Sibley, Rita Bottino, Zachary Freyberg

发表日期：2021

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Pharmacological Characterization of the Imipridone Anticancer Drug ONC201 Reveals a Negative Allosteric Mechanism of Action at the D2 Dopamine Receptor

抗癌药物亚胺吡啶酮 ONC201 的药理学表征揭示了其对 D2 多巴胺受体的负变构作用机制

期刊:Molecular Pharmacology

影响因子:3.2

doi:10.1124/molpharm.121.000336

R Benjamin Free, Caroline A Cuoco, Bing Xie, Yoon Namkung, Varun V Prabhu, Blair K A Willette, Marilyn M Day, Marta Sanchez-Soto, J Robert Lane, Stéphane A Laporte, Lei Shi, Joshua E Allen, David R Sibley

发表日期：2021

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Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist

ML417 的发现、优化和表征：一种新型高选择性 D3 多巴胺受体激动剂

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/acs.jmedchem.0c00424

Amy E Moritz, R Benjamin Free, Warren S Weiner, Emmanuel O Akano, Disha Gandhi, Ara Abramyan, Thomas M Keck, Marc Ferrer, Xin Hu, Noel Southall, Joseph Steiner, Jeffrey Aubé, Lei Shi, Kevin J Frankowski, David R Sibley

发表日期：2020

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Evidence for a Stereoselective Mechanism for Bitopic Activity by Extended-Length Antagonists of the D3 Dopamine Receptor

延长 D3 多巴胺受体拮抗剂的双位活性立体选择性机制的证据

期刊:ACS Chemical Neuroscience

影响因子:4.1

doi:10.1021/acschemneuro.0c00425

Amy E Moritz, Alessandro Bonifazi, Adrian M Guerrero, Vivek Kumar, R Benjamin Free, J Robert Lane, Ravi Kumar Verma, Lei Shi, Amy Hauck Newman, David R Sibley

发表日期：2020

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Ligand with Two Modes of Interaction with the Dopamine D2 Receptor-An Induced-Fit Mechanism of Insurmountable Antagonism

与多巴胺 D2 受体具有两种相互作用模式的配体 - 不可克服的拮抗诱导契合机制

期刊:ACS Chemical Neuroscience

影响因子:4.1

doi:10.1021/acschemneuro.0c00477

Richard Ågren, Hugo Zeberg, Tomasz Maciej Stępniewski, R Benjamin Free, Sean W Reilly, Robert R Luedtke, Peter Århem, Francisco Ciruela, David R Sibley, Robert H Mach, Jana Selent, Johanna Nilsson, Kristoffer Sahlholm

发表日期：2020

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Dopamine D4 Receptor-Selective Compounds Reveal Structure-Activity Relationships that Engender Agonist Efficacy

多巴胺 D4 受体选择性化合物揭示产生激动剂功效的构效关系

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/acs.jmedchem.9b00231

Thomas M Keck, R Benjamin Free, Marilyn M Day, Sonvia L Brown, Michele S Maddaluna, Griffin Fountain, Charles Cooper, Brooke Fallon, Matthew Holmes, Christopher T Stang, Russell Burkhardt, Alessandro Bonifazi, Michael P Ellenberger, Amy H Newman, David R Sibley, Chun Wu, Comfort A Boateng

发表日期：2019

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Structure-Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the D2 Dopamine Receptor

蛋白偏向激动剂的结构-活性研究揭示了 D2 多巴胺受体偏向信号传导的分子决定因素

期刊:Frontiers in Synaptic Neuroscience

影响因子:2.8

doi:10.3389/fnsyn.2018.00002

Lani S Chun, Rakesh H Vekariya, R Benjamin Free, Yun Li, Da-Ting Lin, Ping Su, Fang Liu, Yoon Namkung, Stephane A Laporte, Amy E Moritz, Jeffrey Aubé, Kevin J Frankowski, David R Sibley

发表日期：2018

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