Combined crystallographic fragment screening and deep mutational scanning enable discovery of Zika virus NS2B-NS3 protease inhibitors
结合晶体学片段筛选和深度突变扫描，可以发现寨卡病毒NS2B-NS3蛋白酶抑制剂。
期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-63602-z
Ni, Xiaomin; Richardson, R Blake; Godoy, Andre Schutzer; Ferla, Matteo P; Kikawa, Caroline; Scheen, Jenke; Hannon, William W; Capkin, Eda; Lahav, Noa; Balcomb, Blake H; Marples, Peter G; Fairhead, Michael; Wang, SiYi; Williams, Eleanor P; Tomlinson, Charles W E; Aschenbrenner, Jasmin C; Lithgo, Ryan M; Winokan, Max; Giroud, Charline; Dolci, Isabela; Fernandes, Rafaela Sachetto; Oliva, Glaucius; Chandran, Anu V; Xavier, Mary-Ann; Walsh, Martin A; Thompson, Warren; Bloom, Jesse D; Kenton, Nathaniel T; Lee, Alpha A; von Delft, Annette; Barr, Haim; Kirkegaard, Karla; Koekemoer, Lizbé; Fearon, Daren; Evans, Matthew J; von Delft, Frank
