日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Phenylhydrazone-based endoplasmic reticulum proteostasis regulator compounds with enhanced biological activity.

具有增强生物活性的苯腙类内质网蛋白稳态调节化合物。

Kline Gabriel M, Boinon Lisa, Guerrero Adrian, Kutseikin Sergei, Cruz Gabrielle, Williams Marnie P, Paxman Ryan J, Balch William E, Kelly Jeffery W, Mu Tingwei, Wiseman R Luke

Inflammation and insulin profiles in men assigned to exercise vs. usual care for prostate cancer: results from the active surveillance exercise (ASX) randomized controlled trial

前列腺癌患者接受运动治疗与接受常规治疗后,炎症和胰岛素水平的变化:来自主动监测运动(ASX)随机对照试验的结果

Pace, William A; Olshen, Adam; Wang, Ye; Kenfield, Stacey A; Van Blarigan, Erin L; Graff, Rebecca E; Cowan, Janet; Wang, Lufan; Tenggara, Imelda; Lopez, Karen; Encabo, Katriel; Jones, Lee W; Panchal, Neil; Cooperberg, Matthew R; Carroll, Peter R; Luke, Anthony; Pollak, Michael; Chan, June M

Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4

肿瘤内缺氧通过慢性激活整合应激反应转录因子ATF4促进CD8+ T细胞功能障碍

Coral Del Mar Alicea Pauneto ,Brian P Riesenberg ,Evelyn J Gandy ,Andrew S Kennedy ,Genevieve T Clutton ,Jessica W Hem ,Katie E Hurst ,Elizabeth G Hunt ,Jarred M Green ,Brian C Miller ,Steven P Angus ,Gary L Johnson ,Robert J Esther ,Jennifer L Guerriero ,Peng Gao ,David R Soto-Pantoja ,Robert L Ferris ,Jennifer L Modliszewski ,Michael F Coleman ,H Kay Chung ,J Justin Milner ,Stergios J Moschos ,R Luke Wiseman ,Jessica E Thaxton

Pharmacological targeting of RIG-I can selectively activate the integrated stress response

通过药物靶向RIG-I可以选择性地激活整合应激反应。

Cuoco, Caroline A; Ren, Wen; Baron, Kelsey R; Gologo, Sakina; Perea, Valerie; Mathur, Prakhyat; Bora, Prerona; Ta, Amina; Chu, Alan; Aldakhlallah, Rama; Rhoades, Derek; Cole, Christian M; Tan, Ee Phie; Hou, William C; Yoon, Leonard; Guo, Xiaoyan; Rosarda, Jessica D; Baran, Phil S; Kampmann, Martin; Tillery, Lakeisha; Johnson, Kristen A; Powers, Evan T; Wiseman, R Luke; Kelly, Jeffery W

Activation of XBP1s attenuates disease severity in models of proteotoxic Charcot-Marie-Tooth type 1B

XBP1s 的激活可减轻蛋白毒性夏科-马里-图斯病 1B 型模型中的疾病严重程度。

Touvier, Thierry; Veneri, Francesca A; Claessens, Anke; Ferri, Cinzia; Mastrangelo, Rosa; Sorgiati, Noémie; Bianchi, Francesca; Valenzano, Serena; Del Carro, Ubaldo; Rivellini, Cristina; Duong, Phu; Shy, Michael E; Kelly, Jeffery W; Svaren, John; Wiseman, R Luke; D'Antonio, Maurizio

Radiomic analysis of patient and interorgan heterogeneity in response to immunotherapies and BRAF-targeted therapy in metastatic melanoma

转移性黑色素瘤患者及器官间异质性对免疫疗法和BRAF靶向治疗反应的放射组学分析

Tompkins, Alexandra G; Gray, Zane N; Dadey, Rebekah E; Zenkin, Serafettin; Batavani, Nasim; Newman, Sarah; Amouzegar, Afsaneh; Ak, Murat; Ak, Nursima; Pak, Taha Yasin; Peddagangireddy, Vishal; Mamindla, Priyadarshini; Amjadzadeh, Mohammadreza; Behr, Sarah; Goodman, Amy; Ploucha, Darcy L; Kirkwood, John M; Zarour, Hassane M; Najjar, Yana G; Davar, Diwakar; Tatsuoka, Curtis; Colen, Rivka R; Luke, Jason John; Bao, Riyue

Drug repurposing screen identifies an HRI activating compound that promotes adaptive mitochondrial remodeling in MFN2-deficient cells.

药物再利用筛选发现了一种 HRI 激活化合物,该化合物可促进 MFN2 缺陷细胞中的线粒体适应性重塑。

Bora Prerona, Zaman Mashiat, Oviedo Samantha, Kutseikin Sergei, Madrazo Nicole, Mathur Prakhyat, Pannikkat Meera, Krasny Sophia, Aldakhlallah Rama, Chu Alan, Johnson Kristen A, Grotjahn Danielle A, Shutt Timothy E, Wiseman R Luke

Pharmacologic activation of integrated stress response kinases inhibits pathologic mitochondrial fragmentation.

整合应激反应激酶的药理学激活可抑制病理性线粒体碎片化

Baron Kelsey R, Oviedo Samantha, Krasny Sophia, Zaman Mashiat, Aldakhlallah Rama, Bora Prerona, Mathur Prakhyat, Pfeffer Gerald, Bollong Michael J, Shutt Timothy E, Grotjahn Danielle A, Wiseman R Luke

AA147 Alleviates Symptoms in a Mouse Model of Multiple Sclerosis by Reducing Oligodendrocyte Loss.

AA147 通过减少少突胶质细胞丢失来缓解多发性硬化症小鼠模型的症状

Aksu Metin, Kaschke Kevin, Podojil Joseph R, Chiang MingYi, Steckler Ian, Bruce Kody, Cogswell Andrew C, Schulz Gwen, Kelly Jeffery W, Wiseman R Luke, Miller Stephen D, Popko Brian, Chen Yanan

Improving Proteostasis of Trafficking-Deficient GABA(A) Receptor Variants by Activating IRE1.

通过激活 IRE1 改善转运缺陷 GABA(A) 受体变体的蛋白质稳态。

Fu Xu, Wang Ya-Juan, Lee KyungA, Ahn Lucie Y, Chen Xi, Harvey Brock T, Wang Meng, Seibert Hailey, Zhang Pei-Pei, Guerrero Adrian, Schaffer Ashleigh E, Richards Christopher I, Wiseman R Luke, Kelly Jeffery W, Mu Ting-Wei