Rachel E Simmonds相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

The Mycobacterium ulcerans toxin mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane to drive skin necrosis

溃疡分枝杆菌毒素 mycolactone 可导致内皮糖萼和血管基底膜破坏性地丢失，从而导致皮肤坏死

影响因子:6.4

doi:10.7554/eLife.86931

Louise Tzung-Harn Hsieh #, Belinda S Hall #, Jane Newcombe, Tom A Mendum, Sonia Santana Varela, Yagnesh Umrania, Michael J Deery, Wei Q Shi, Josué Diaz-Delgado, Francisco J Salguero, Rachel E Simmonds

发表日期：2025

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Mycolactone causes catastrophic Sec61-dependent loss of the endothelial glycocalyx and basement membrane: a new indirect mechanism driving tissue necrosis in Mycobacterium ulcerans infection

肌内酯导致内皮糖萼和基底膜发生灾难性的 Sec61 依赖性损失：一种导致溃疡分枝杆菌感染组织坏死的新的间接机制

doi:10.1101/2023.02.21.529382

Louise Tzung-Harn Hsieh, Belinda S Hall, Jane Newcombe, Tom A Mendum, Yagnesh Umrania, Michael J Deery, Wei Q Shi, Francisco J Salguero, Rachel E Simmonds

发表日期：2023

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Inhibition of the SEC61 translocon by mycolactone induces a protective autophagic response controlled by EIF2S1-dependent translation that does not require ULK1 activity

肌内酯抑制 SEC61 转运蛋白可诱导由 EIF2S1 依赖性翻译控制的保护性自噬反应，而这种反应不需要 ULK1 活性

期刊:Autophagy

影响因子:14.6

doi:10.1080/15548627.2021.1961067

Belinda S Hall, Scott J Dos Santos, Louise Tzung-Harn Hsieh, Maria Manifava, Marie-Thérèse Ruf, Gerd Pluschke, Nicholas Ktistakis, Rachel E Simmonds

细胞生物学

Translational Control

发表日期：2022

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Aberrant stromal tissue factor localisation and mycolactone-driven vascular dysfunction, exacerbated by IL-1β, are linked to fibrin formation in Buruli ulcer lesions

异常的基质组织因子定位和肌内酯驱动的血管功能障碍（因 IL-1β 而加剧）与布鲁里溃疡病变中的纤维蛋白形成有关

期刊:PLoS Pathogens

影响因子:5.5

doi:10.1371/journal.ppat.1010280

Louise Tzung-Harn Hsieh, Scott J Dos Santos, Belinda S Hall, Joy Ogbechi, Aloysius D Loglo, Francisco Javier Salguero, Marie-Thérèse Ruf, Gerd Pluschke, Rachel E Simmonds

发表日期：2022

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Structure of the Inhibited State of the Sec Translocon

抑制状态下的 Sec 转运蛋白的结构

期刊:Molecular Cell

影响因子:14.5

doi:10.1016/j.molcel.2020.06.013

Samuel F Gérard, Belinda S Hall, Afroditi M Zaki, Katherine A Corfield, Peter U Mayerhofer, Catia Costa, Daniel K Whelligan, Philip C Biggin, Rachel E Simmonds, Matthew K Higgins

发表日期：2020

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Transient up-regulation of miR-155-3p by lipopolysaccharide in primary human monocyte-derived macrophages results in RISC incorporation but does not alter TNF expression

脂多糖在原代人类单核细胞衍生的巨噬细胞中短暂上调 miR-155-3p 导致 RISC 掺入，但不会改变 TNF 表达

期刊:Wellcome Open Research

doi:10.12688/wellcomeopenres.15065.2

Rachel E Simmonds

细胞生物学

发表日期：2019

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Mechanistic insights into the inhibition of Sec61-dependent co- and post-translational translocation by mycolactone

肌内酯抑制 Sec61 依赖性共翻译和翻译后易位的机制见解

期刊:Journal of Cell Science

影响因子:3.3

doi:10.1242/jcs.182352

Michael McKenna, Rachel E Simmonds, Stephen High

发表日期：2016

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The pathogenic mechanism of the Mycobacterium ulcerans virulence factor, mycolactone, depends on blockade of protein translocation into the ER

溃疡分枝杆菌毒力因子 mycolactone 的致病机制依赖于阻断蛋白质转位进入内质网

期刊:PLoS Pathogens

影响因子:5.5

doi:10.1371/journal.ppat.1004061

Belinda S Hall, Kirsti Hill, Michael McKenna, Joy Ogbechi, Stephen High, Anne E Willis, Rachel E Simmonds

发表日期：2014

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