日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

mTOR and HDAC Inhibitors Converge on the TXNIP/Thioredoxin Pathway to Cause Catastrophic Oxidative Stress and Regression of RAS-Driven Tumors

mTOR 和 HDAC 抑制剂汇聚在 TXNIP/硫氧还蛋白通路上,导致灾难性的氧化应激和 RAS 驱动的肿瘤消退

Clare F Malone, Chloe Emerson, Rachel Ingraham, William Barbosa, Stephanie Guerra, Haejin Yoon, Lin L Liu, Franziska Michor, Marcia Haigis, Kay F Macleod, Ophélia Maertens, Karen Cichowski

Cotargeting MNK and MEK kinases induces the regression of NF1-mutant cancers

共同靶向 MNK 和 MEK 激酶可诱导 NF1 突变癌症消退

Rebecca Lock, Rachel Ingraham, Ophélia Maertens, Abigail L Miller, Nelly Weledji, Eric Legius, Bruce M Konicek, Sau-Chi B Yan, Jeremy R Graff, Karen Cichowski

Defining key signaling nodes and therapeutic biomarkers in NF1-mutant cancers

定义 NF1 突变癌症中的关键信号节点和治疗生物标志物

Clare F Malone, Jody A Fromm, Ophélia Maertens, Thomas DeRaedt, Rachel Ingraham, Karen Cichowski

CXCL12/CXCR4 blockade induces multimodal antitumor effects that prolong survival in an immunocompetent mouse model of ovarian cancer

CXCL12/CXCR4 阻断可诱导多模式抗肿瘤作用,延长免疫功能正常的卵巢癌小鼠模型的生存期

Elda Righi #, Satoshi Kashiwagi #, Jianping Yuan, Michael Santosuosso, Pierre Leblanc, Rachel Ingraham, Benjamin Forbes, Beth Edelblute, Brian Collette, Deyin Xing, Magdalena Kowalski, Maria Cristina Mingari, Fabrizio Vianello, Michael Birrer, Sandra Orsulic, Glenn Dranoff, Mark C Poznansky