Increasing serum half-life and extending cholesterol lowering in vivo by engineering antibody with pH-sensitive binding to PCSK9
通过设计与 PCSK9 具有 pH 敏感结合的抗体来增加血清半衰期并延长体内降低胆固醇的时间
期刊:Journal of Biological Chemistry
影响因子:4
doi:10.1074/jbc.M111.319764
Javier Chaparro-Riggers, Hong Liang, Rachel M DeVay, Lanfang Bai, Janette E Sutton, Wei Chen, Tao Geng, Kevin Lindquist, Meritxell Galindo Casas, Leila M Boustany, Colleen L Brown, Jeffrey Chabot, Bruce Gomes, Pamela Garzone, Andrea Rossi, Pavel Strop, Dave Shelton, Jaume Pons, Arvind Rajpal