日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The histone chaperone SPT2 regulates chromatin structure and function in Metazoa

组蛋白伴侣SPT2调控后生动物的染色质结构和功能

Giulia Saredi,Francesco N Carelli,Stéphane G M Rolland #,Giulia Furlan #,Sandra Piquet #,Alex Appert #,Luis Sanchez-Pulido,Jonathan L Price,Pablo Alcon,Lisa Lampersberger,Anne-Cécile Déclais,Navin B Ramakrishna,Rachel Toth,Thomas Macartney,Constance Alabert,Chris P Ponting,Sophie E Polo,Eric A Miska,Anton Gartner,Julie Ahringer,John Rouse

Mechanism of human PINK1 activation at the TOM complex in a reconstituted system

重组系统中人类 PINK1 在 TOM 复合体上的激活机制

Olawale G Raimi, Hina Ojha, Kenneth Ehses, Verena Dederer, Sven M Lange, Cristian Polo Rivera, Tom D Deegan, Yinchen Chen, Melanie Wightman, Rachel Toth, Karim P M Labib, Sebastian Mathea, Neil Ranson, Rubén Fernández-Busnadiego, Miratul M K Muqit

Chemo-Phosphoproteomic Profiling with ATR Inhibitors Berzosertib and Gartisertib Uncovers New Biomarkers and DNA Damage Response Regulators

利用 ATR 抑制剂 Berzosertib 和 Gartisertib 进行化学-磷酸化蛋白质组学分析,揭示了新的生物标志物和 DNA 损伤反应调节因子

Rathan Jadav ,Florian Weiland ,Sylvie M Noordermeer ,Thomas Carroll ,Yuandi Gao ,Jianming Wang ,Houjiang Zhou ,Frederic Lamoliatte ,Rachel Toth ,Thomas Macartney ,Fiona Brown ,C James Hastie ,Constance Alabert ,Haico van Attikum ,Frank Zenke ,Jean-Yves Masson ,John Rouse

PROTAC-mediated conditional degradation of the WRN helicase as a potential strategy for selective killing of cancer cells with microsatellite instability

PROTAC 介导的 WRN 解旋酶条件性降解是选择性杀死具有微卫星不稳定性癌细胞的潜在策略

Vikram Tejwani, Thomas Carroll, Thomas Macartney, Susanne Bandau, Constance Alabert, Giulia Saredi, Rachel Toth, John Rouse

USP27X variants underlying X-linked intellectual disability disrupt protein function via distinct mechanisms

导致X连锁智力障碍的USP27X变异体通过不同的机制破坏蛋白质功能。

Intisar Koch,Maya Slovik,Yuling Zhang,Bingyu Liu,Martin Rennie,Emily Konz,Benjamin Cogne,Muhannad Daana,Laura Davids,Illja J Diets,Nina B Gold,Alexander M Holtz,Bertrand Isidor,Hagar Mor-Shaked,Juanita Neira Fresneda,Karen Y Niederhoffer,Mathilde Nizon,Rolph Pfundt,Meh Simon,Apa Stegmann,Maria J Guillen Sacoto,Marijke Wevers,Tahsin Stefan Barakat,Shira Yanovsky-Dagan,Boyko S Atanassov,Rachel Toth,Chengjiang Gao,Francisco Bustos,Tamar Harel

Structure-based design and characterization of Parkin-activating mutations

基于结构的 Parkin 激活突变设计和表征

Michael U Stevens, Nathalie Croteau, Mohamed A Eldeeb, Odetta Antico, Zhi Wei Zeng, Rachel Toth, Thomas M Durcan, Wolfdieter Springer, Edward A Fon, Miratul Mk Muqit, Jean-François Trempe

Functional characterization of C21ORF2 association with the NEK1 kinase mutated in human in diseases

C21ORF2 与人类疾病中突变的 NEK1 激酶的关联功能表征

Mateusz Gregorczyk ,Graziana Pastore ,Ivan Muñoz ,Thomas Carroll ,Johanna Streubel ,Meagan Munro ,Pawel Lis ,Sven Lange ,Frederic Lamoliatte ,Thomas Macartney ,Rachel Toth ,Fiona Brown ,James Hastie ,Gislene Pereira ,Daniel Durocher ,John Rouse

Differential roles and regulation of the protein kinases PAK4, PAK5 and PAK6 in melanoma cells

蛋白激酶 PAK4、PAK5 和 PAK6 在黑色素瘤细胞中的不同作用和调节

Gavuthami Murugesan, Alan R Prescott, Rachel Toth, David G Campbell, Claire M Wells, Carol MacKintosh

An RNF12-USP26 amplification loop drives germ cell specification and is disrupted by disease-associated mutations

RNF12-USP26 扩增环路驱动生殖细胞特化,并被疾病相关的突变破坏

Anna Segarra-Fas, Carmen Espejo-Serrano, Francisco Bustos, Houjiang Zhou, Feng Wang, Rachel Toth, Thomas Macartney, Ingolf Bach, Gino Nardocci, Greg M Findlay

Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1

对原代神经元线粒体的全局泛素化分析确定了 PINK1 激活后的内源性 Parkin 靶点

Odetta Antico, Alban Ordureau, Michael Stevens, Francois Singh, Raja S Nirujogi, Marek Gierlinski, Erica Barini, Mollie L Rickwood, Alan Prescott, Rachel Toth, Ian G Ganley, J Wade Harper, Miratul M K Muqit