日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

EGFR inhibitor-resistant lung cancers exhibit collateral sensitivity to a covalent, cysteine-independent KEAP1 oligomerizing molecular bridge.

对 EGFR 抑制剂耐药的肺癌表现出对共价、不依赖半胱氨酸的 KEAP1 寡聚化分子桥的协同敏感性。

Bassil Christopher F, Dillon Kerry, Anderson Gray R, Mayro Benjamin, Askin Kayleigh N, Winter Peter S, Harry Stefan, Gruber Samuel, Hall Tierney M, Hoj Jacob P, Cerda-Smith Christian, Hutchinson Haley M, Killarney Shane T, Heffernan Ava, Teddy Caroline, Singleton Katherine R, Qin Li, Jubien-Girard Kévin, Favreau Cécile, Robert Guillaume, Tivon Barr, Livnah Ella, London Nir, Benhida Rachid, Auberger Patrick, Pendergast Ann Marie, Bar-Peled Liron, Lonard David M, Martin Anthony R, Puissant Alexandre, Wood Kris C

Intradermal delivery of lipophilic siRNAs enables prolonged skin retention and sustained gene silencing in a porcine model.

在猪模型中,皮内注射亲脂性siRNA可实现皮肤长期滞留和持续基因沉默。

Fakih Hassan H, Zain Ui Abideen Mohammad, Rachid Mohamad Omar, Gross Katherine Y, Ormsby Thomas J R, Ross Vella M, Gagnon Rosemary, Dahlke Christopher, Furgal Raymond C, Lochmann Clemens, Summers Ashley, Sleiman Hanadi F, Fürst Sylvia M, Jackson Shanté N, Gordilho Juliana O, Bouix-Peter Claire, Portal Thibaud, Tang Qi, Harris John E, Khvorova Anastasia, Blanchard Carine, Alterman Julia F

An artificial intelligence-powered learning health system to improve sepsis detection and quality of care: a before-and-after study

利用人工智能驱动的学习型医疗系统提高脓毒症检测率和医疗质量:一项前后对比研究

Despraz, Jérémie; Matusiak, Raphaël; Nektarijevic, Snežana; Rossetti, Valerio; Bastardot, François; Akrour, Rachid; Konasch, Andreas; Gauthiez, Emeline; Pignolet, Olivier; Pepe, Santino; Chiche, Jean-Daniel; Kaufmann, Daniel E; Calandra, Thierry; Raisaro, Jean Louis; Meylan, Sylvain

Navigating the evolving management of smoldering multiple myeloma

应对不断变化的冒烟型多发性骨髓瘤的治疗策略

Hammami, M Bakri; Canevarolo, Rafael R; Silva, Ariosto S; Alsina, Melissa; Kumar, Nagi; Baz, Rachid; Shain, Kenneth H

Molecular engineering of lysosome-based degraders unveils a rapidly expanding therapeutic strategy

溶酶体降解剂的分子工程改造揭示了一种快速发展的治疗策略

Rivault, Adele; Dussart-Gautheret, Jade; Benhida, Rachid; Martin, Anthony R; Auberger, Patrick; Jacquel, Arnaud; Robert, Guillaume

Dual targeting of GPX4 and TXNRD1 triggers eradication of AML cells through induction of apoptosis and ferroptosis

GPX4 和 TXNRD1 的双重靶向作用可通过诱导细胞凋亡和铁死亡来清除 AML 细胞。

Favreau, Cécile; Bourgoin, Maxence; Savy, Coline; Botton, Thomas; Bailly, Sarah; Granger, Florence; Birck, Catherine; Zerhouni, Marwa; Kerreneur, Emeline; Rivault, Adele; Vigroux, Alban; Dussart-Gautheret, Jade; Arcangeli, Marie-Laure; Poterszman, Arnaud; Cluzeau, Thomas; Rocchi, Stephane; Jacquel, Arnaud; Benhida, Rachid; Auberger, Patrick; Martin, Anthony R; Robert, Guillaume

Presence of phosphodiester backbone, but not nucleobases, in the guide's 3' terminal region is necessary for RISC loading and target cleavage in vitro and in vivo

引导RNA 3'末端区域中磷酸二酯骨架的存在(而非核碱基的存在)是RISC在体外和体内装载和靶标切割所必需的。

O'Reilly, Daniel; Furgal, Raymond C; Ross, Vella M; Luu, Eric; Gross, Katherine Y; Hariharan, Vignesh; Summers, Ashley; Cooper, David; Allen, Sarah; Dahlke, Christopher; Rachid, Mohamad Omar; Chan, Io Long; Fakih, Hassan H; Alterman, Julia F; Echeverria, Dimas; Watts, Jonathan K; Khvorova, Anastasia

Real-world outcomes with elranatamab in multiple myeloma: a multicenter analysis from the U.S. Multiple Myeloma Immunotherapy Consortium

elranatamab治疗多发性骨髓瘤的真实世界疗效:来自美国多发性骨髓瘤免疫治疗联盟的多中心分析

Portuguese, Andrew J; Davis, James A; Raza, Shahzad; Castaneda Puglianini, Omar; Freeman, Ciara; Alsina, Melissa; Wright, Corbin; Blue, Brandon J; Baz, Rachid C; Shain, Kenneth H; Goel, Utkarsh; Khouri, Jack; Anwer, Faiz; Ali, Hossam M; Pasvolsky, Oren; Gaballa, Mahmoud; Patel, Krina; Garcia-Pleitez, Hector; Mikulski, Damian; Fogel, Lindsay; Zolotov, Eli; Sannareddy, Aishwarya; Afrough, Aimaz; Anderson, Larry D Jr; Julian, Kelley; Dima, Danai; Banerjee, Rahul; Liang, Emily C; Cassano Cassano, Raffaella; Herr, Megan M; Hassan, Hamza; Shune, Leyla; Kort, Jeries; Midha, Shonali; Nadeem, Omar; Sidana, Surbhi; Lin, Yi; Locke, Frederick L; Hansen, Doris K; Sborov, Douglas; Biran, Noa; Grajales-Cruz, Ariel

Ortho-phosphite (PO33-) : Mechanochemical Synthesis of a Missing Oxoanion and Precursor to Value-Added Organophosphorus Compounds

正亚磷酸根(PO33-):缺失的含氧阴离子的机械化学合成及高附加值有机磷化合物的前体

Löwe, Pawel; Taakili, Rachid; Xin, Tiansi; Haldar, Hritwik; Herzog, Antonia; Shao-Horn, Yang; Cummins, Christopher C

Persistent PI3K-AKT signaling fortifies cellular defense against oxidative stress and ferroptosis through augmented mitochondrial fitness

持续的PI3K-AKT信号通路通过增强线粒体功能来强化细胞抵抗氧化应激和铁死亡的能力。

Xie, Xin; Wang, Shanshan; Zeng, Wentao; Long, Xiaohang; Zheng, Daheng; Ye, Jianping; Rezgui, Rachid; Liu, Pu-Ste