日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Loss of DDI2 rewires proteostasis through CCN1-driven compensatory autophagy.

DDI2 的缺失通过 CCN1 驱动的补偿性自噬重塑蛋白质稳态。

Hosseini Nayyerehalsadat, Elshazly Ahmed M, Byers Holly A, Ward Madison A, Brooks Amy N, Vangala Janakiram R, Radhakrishnan Senthil K

Targeting SUMOylation promotes cBAF complex stabilization and disruption of the SS18::SSX transcriptome in synovial sarcoma.

靶向 SUMO 化可促进 cBAF 复合物的稳定,并破坏滑膜肉瘤中的 SS18::SSX 转录组。

Floros Konstantinos V, Fairchild Carter K Jr, Li Jinxiu, Zhang Kun, Roberts Jane L, Kurupi Richard, Paudel Durga, Xing Yanli, Hu Bin, Kraskauskiene Vita, Hosseini Nayyerehalsadat, Shen Shanwei, Inge Melissa M, Smith-Fry Kyllie, Li Li, Sotiriou Afroditi, Dalton Krista M, Jose Asha, Abdelfadiel Elsamani I, Hill Ronald D, Slaughter Jamie M, Shende Mayuri, Lorenz Madelyn R, Tanaka Noritaka, Kajino Taisuke, Nelson Mary L, Hinojosa Mandy R, Kehinde Victor A, Belvin Benjamin R, Sugiokto Febri G, Lai Zhao, Dimopoulos Alexandros C, Boikos Sosipatros A, Stamatouli Angeliki M, Lewis Janina P, Manjili Masoud H, Ebi Hiromichi, Valerie Kristoffer, Li Renfeng, Poklepovic Andrew, Koblinski Jennifer E, Siggers Trevor, Banito Ana, Dozmorov Mikhail G, Jones Kevin B, Radhakrishnan Senthil K, Faber Anthony C

Anthracyclines attenuate Nrf1-dependent proteolytic pathways and potentiate proteasome inhibitor cytotoxicity

蒽环类药物可减弱 Nrf1 依赖性蛋白水解途径,并增强蛋白酶体抑制剂的细胞毒性。

Vangala, Janakiram R; Ward, Madison A; Albalawi, Bader; Elshazly, Ahmed M; Hosseini, Nayyerehalsadat; Shen, Shanwei; Byers, Holly A; Carter, Christiane; Liu, Jinze; Radhakrishnan, Senthil K

Proteasome Inhibition Enhances Lysosome-mediated Targeted Protein Degradation

蛋白酶体抑制增强溶酶体介导的靶向蛋白降解

Elshazly, Ahmed M; Hosseini, Nayyerehalsadat; Shen, Shanwei; Neely, Victoria; Harada, Hisashi; Grant, Steven; Radhakrishnan, Senthil K

The Human Intermediate Prolactin Receptor I-tail Contributes Breast Oncogenesis by Targeting Ras/MAPK Pathway.

人类中间催乳素受体 I 尾通过靶向 Ras/MAPK 通路促进乳腺癌发生

Shen Shanwei, Radhakrishnan Senthil K, Harrell J Chuck, Puchalapalli Madhavi, Koblinski Jennifer, Clevenger Charles

Evaluation of the NRF1-proteasome axis as a therapeutic target in breast cancer.

评估 NRF1-蛋白酶体轴作为乳腺癌治疗靶点的可能性

Byers Holly A, Brooks Amy N, Vangala Janakiram R, Grible Jacqueline M, Feygin Alex, Clevenger Charles V, Harrell J Chuck, Radhakrishnan Senthil K

Trash Talk: Mammalian Proteasome Regulation at the Transcriptional Level

垃圾话:哺乳动物蛋白酶体在转录水平的调控

Kamber Kaya, Hatem Elif; Radhakrishnan, Senthil K

Disabling the Protease DDI2 Attenuates the Transcriptional Activity of NRF1 and Potentiates Proteasome Inhibitor Cytotoxicity.

抑制蛋白酶 DDI2 可减弱 NRF1 的转录活性并增强蛋白酶体抑制剂的细胞毒性

Northrop Amy, Vangala Janakiram R, Feygin Alex, Radhakrishnan Senthil K

Regulation of NRF1, a master transcription factor of proteasome genes: implications for cancer and neurodegeneration

NRF1(蛋白酶体基因的关键转录因子)的调控:对癌症和神经退行性疾病的意义

Northrop, Amy; Byers, Holly A; Radhakrishnan, Senthil K

Inhibition of NGLY1 Inactivates the Transcription Factor Nrf1 and Potentiates Proteasome Inhibitor Cytotoxicity

抑制NGLY1可使转录因子Nrf1失活并增强蛋白酶体抑制剂的细胞毒性

Tomlin, Frederick M; Gerling-Driessen, Ulla I M; Liu, Yi-Chang; Flynn, Ryan A; Vangala, Janakiram R; Lentz, Christian S; Clauder-Muenster, Sandra; Jakob, Petra; Mueller, William F; Ordoñez-Rueda, Diana; Paulsen, Malte; Matsui, Naoko; Foley, Deirdre; Rafalko, Agnes; Suzuki, Tadashi; Bogyo, Matthew; Steinmetz, Lars M; Radhakrishnan, Senthil K; Bertozzi, Carolyn R