Directed evolution of metalloproteinase inhibitor TIMP-1 for selective inhibition of MMP-9 exploits catalytic and fibronectin domain interactions
利用催化结构域和纤连蛋白结构域的相互作用,定向进化金属蛋白酶抑制剂TIMP-1以实现对MMP-9的选择性抑制。
期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1016/j.jbc.2025.110258
Shoari, Alireza; Coban, Mathew A; Hockla, Alexandra; Rezhdo, Arlinda; Dimesa, Alexandra M; Raeeszadeh-Sarmazdeh, Maryam; Van Deventer, James A; Radisky, Evette S