日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Deep learning-based assessment of PD-L1 expression in NSCLC predicts outcome for patients treated with anti-PD-1 immunotherapy

基于深度学习的非小细胞肺癌PD-L1表达评估可预测接受抗PD-1免疫疗法治疗患者的预后

Peroz, Morgane; Roussot, Nicolas; Ilie, Alis; Rageot, David; Derangere, Valentin; Truntzer, Caroline; Ghiringhelli, François

Safety and efficacy of trifluridine/tipiracil +/- bevacizumab plus XB2001 (anti-IL-1α antibody): a single-center phase 1 trial

三氟尿苷/替吡嘧啶联合或不联合贝伐珠单抗加XB2001(抗IL-1α抗体)的安全性和有效性:一项单中心1期试验

Marion Thibaudin ,Nicolas Roussot ,Chloé Burlot ,Antonin Schmitt ,Julie Vincent ,Zoé Tharin ,Leila Bengrine ,Hélène Bellio ,Aurélie Bertaut ,Léa Hampe ,Susy Daumoine ,Emilie Rederstorff ,Morgane Peroz ,Titouan Huppe ,Valentin Derangère ,David Rageot ,John Simard ,Caroline Truntzer ,Jean David Fumet ,Francois Ghiringhelli

Cancer cell-derived IL-1β reverses chemo-immunotherapy resistance in non-small cell lung cancer

癌细胞来源的IL-1β可逆转非小细胞肺癌的化疗-免疫治疗耐药性

Anaïs Perrichet ,Julie Lecuelle ,Emeric Limagne ,Marie Thiefin ,Hélène Bellio ,Pierre Jacob ,Romain Aucagne ,Aziza Aznague ,Pauline Russo ,Flavie Gaucher ,Nicolas Roussot ,Xingping Yang ,Thibault Vernet ,Lisa Nuttin ,Alis Ilie ,David Rageot ,Valentin Derangère ,Titouan Huppe ,Alfred Zippelius ,Bertrand Routy ,Caroline Truntzer ,Fanny Chalmin ,François Ghiringhelli # ,Cédric Rébé #

Co-targeting TGF-β and PD-L1 sensitizes triple-negative breast cancer to experimental immunogenic cisplatin-eribulin chemotherapy doublet.

共同靶向 TGF-β 和 PD-L1 可使三阴性乳腺癌对实验性免疫原性顺铂-艾立布林双药化疗敏感

Kalfeist Laura, Ledys Fanny, Petit Stacy, Poirrier Cyriane, Kada Mohammed Samia, Galland Loïck, Derangère Valentin, Ilie Alis, Rageot David, Aucagne Romain, Bellaye Pierre-Simon, Truntzer Caroline, Thibaudin Marion, Rialland Mickaël, Ghiringhelli François, Limagne Emeric, Ladoire Sylvain

Nanostructured lipid carriers based mRNA vaccine leads to a T cell-inflamed tumour microenvironment favourable for improving PD-1/PD-L1 blocking therapy and long-term immunity in a cold tumour model

基于纳米结构脂质载体的mRNA疫苗可诱导T细胞浸润的肿瘤微环境,有利于增强PD-1/PD-L1阻断疗法的疗效,并在冷肿瘤模型中实现长期免疫。

Carole Fournier ,Marion Mercey-Ressejac ,Valentin Derangère ,Amal Al Kadi ,David Rageot ,Christine Charrat ,Alexis Leroy ,Julien Vollaire ,Véronique Josserand ,Marie Escudé ,Séverine Escaich ,François Ghiringhelli ,Thomas Decaens ,Fabrice P Navarro ,Evelyne Jouvin-Marche ,Patrice N Marche

Machine learning evaluation of immune infiltrate through digital tumour score allows prediction of survival outcome in a pooled analysis of three international stage III colon cancer cohorts

通过数字肿瘤评分对免疫浸润进行机器学习评估,可以预测三个国际 III 期结肠癌队列的汇总分析中的生存结果。

Lecuelle, Julie; Truntzer, Caroline; Basile, Debora; Laghi, Luigi; Greco, Luana; Ilie, Alis; Rageot, David; Emile, Jean-François; Bibeau, Fréderic; Taïeb, Julien; Derangere, Valentin; Lepage, Come; Ghiringhelli, François

CD3-CD8 immune score associated with a clinical score stratifies PDAC prognosis regardless of adjuvant or neoadjuvant chemotherapy

CD3-CD8免疫评分与临床评分相结合,可对PDAC预后进行分层,而与辅助或新辅助化疗无关。

Schoumacher, Coralie; Derangère, Valentin; Gaudillière-Le Dain, Gwladys; Huppe, Titouan; Rageot, David; Ilie, Alis; Vienot, Angélique; Borg, Christophe; Monnien, Franck; Bibeau, Frederic; Truntzer, Caroline; Ghiringhelli, François

Case report: Immune response characterization of a pseudoprogression in a PD-L1-negative, TMB-low, KEAP1/STK11 co-mutated metastatic NSCLC

病例报告:PD-L1 阴性、TMB 低、KEAP1/STK11 共突变转移性 NSCLC 中假进展的免疫反应特征

Nicolas Roussot, Marion Thibaudin, Jean-David Fumet, Susy Daumoine, Léa Hampe, Cédric Rébé, Emeric Limagne, Aurélie Lagrange, Victor Herreros, Julie Lecuelle, Hugo Mananet, Alis Ilie, David Rageot, Romain Boidot, Vincent Goussot, Anthony Comte, Pierre Jacob, Françoise Beltjens, Anthony Bergeron, Cél

Deep Multiple Instance Learning Model to Predict Outcome of Pancreatic Cancer Following Surgery

深度多示例学习模型预测胰腺癌术后预后

Truntzer, Caroline; Ouahbi, Dina; Huppé, Titouan; Rageot, David; Ilie, Alis; Molimard, Chloe; Beltjens, Françoise; Bergeron, Anthony; Vienot, Angelique; Borg, Christophe; Monnien, Franck; Bibeau, Frédéric; Derangère, Valentin; Ghiringhelli, François

The Endogenous Inhibitor of CETP, apoC1, Remains Ineffective In Vivo after Correction of Hyperglycemia in People with Type 1 Diabetes

型糖尿病患者高血糖纠正后,CETP 内源性抑制剂 apoC1 在体内仍然无效

Alexia Rouland, Thomas Gautier, Damien Denimal, Laurence Duvillard, Isabelle Simoneau, David Rageot, Bruno Vergès, Benjamin Bouillet