日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Atomically accurate de novo design of antibodies with RFdiffusion

利用射频扩散技术进行原子级精确的抗体从头设计

Bennett, Nathaniel R; Watson, Joseph L; Ragotte, Robert J; Borst, Andrew J; See, DéJenaé L; Weidle, Connor; Biswas, Riti; Yu, Yutong; Shrock, Ellen L; Ault, Russell; Leung, Philip J Y; Huang, Buwei; Goreshnik, Inna; Tam, John; Carr, Kenneth D; Singer, Benedikt; Criswell, Cameron; Wicky, Basile I M; Vafeados, Dionne; Garcia Sanchez, Mariana; Kim, Ho Min; Vázquez Torres, Susana; Chan, Sidney; Sun, Shirley M; Spear, Timothy T; Sun, Yi; O'Reilly, Keelan; Maris, John M; Sgourakis, Nikolaos G; Melnyk, Roman A; Liu, Chang C; Baker, David

CF2H: a cell-free two-hybrid platform for rapid protein binder screening

CF2H:一种用于快速蛋白质结合筛选的无细胞双杂交平台

Capin, Julien; Mayonove, Pauline; DeVisch, Angelique; Becher, Amon; Ngo, Giang; Courbet, Alexis; Ragotte, Robert J; Cohen Gonsaud, Martin; Espeut, Julien; Bonnet, Jerome

De novo designed proteins neutralize lethal snake venom toxins

从头设计的蛋白质能够中和致命的蛇毒毒素

Vázquez Torres, Susana; Benard Valle, Melisa; Mackessy, Stephen P; Menzies, Stefanie K; Casewell, Nicholas R; Ahmadi, Shirin; Burlet, Nick J; Muratspahić, Edin; Sappington, Isaac; Overath, Max D; Rivera-de-Torre, Esperanza; Ledergerber, Jann; Laustsen, Andreas H; Boddum, Kim; Bera, Asim K; Kang, Alex; Brackenbrough, Evans; Cardoso, Iara A; Crittenden, Edouard P; Edge, Rebecca J; Decarreau, Justin; Ragotte, Robert J; Pillai, Arvind S; Abedi, Mohamad; Han, Hannah L; Gerben, Stacey R; Murray, Analisa; Skotheim, Rebecca; Stuart, Lynda; Stewart, Lance; Fryer, Thomas J A; Jenkins, Timothy P; Baker, David

De novo design of potent inhibitors of clostridial family toxins

从头设计高效梭菌毒素抑制剂

Ragotte, Robert J; Liang, Huazhu; Tam, John; Miletic, Sean; Berman, Jacob M; Palou, Roger; Weidle, Connor; Li, Zhijie; Glögl, Matthias; Beilhartz, Greg L; Carr, Kenneth D; Borst, Andrew J; Coventry, Brian; Wang, Xinru; Rubinstein, John L; Tyers, Mike; Schramek, Daniel; Melnyk, Roman A; Baker, David

Designed miniproteins potently inhibit and protect against MERS-CoV.

设计的微型蛋白质能有效抑制和抵抗中东呼吸综合征冠状病毒(MERS-CoV)

Ragotte Robert J, Tortorici M Alejandra, Catanzaro Nicholas J, Addetia Amin, Coventry Brian, Froggatt Heather M, Lee Jimin, Stewart Cameron, Brown Jack T, Goreshnik Inna, Sims Jeremiah N, Milles Lukas F, Wicky Basile I M, Glögl Matthias, Gerben Stacey, Kang Alex, Bera Asim K, Sharkey William, Schäfer Alexandra, Harkema Jack R, Baric Ralph S, Baker David, Veesler David

Atomically accurate de novo design of antibodies with RFdiffusion

利用射频扩散技术进行原子级精确的抗体从头设计

Bennett, Nathaniel R; Watson, Joseph L; Ragotte, Robert J; Borst, Andrew J; See, DéJenaé L; Weidle, Connor; Biswas, Riti; Yu, Yutong; Shrock, Ellen L; Ault, Russell; Leung, Philip J Y; Huang, Buwei; Goreshnik, Inna; Tam, John; Carr, Kenneth D; Singer, Benedikt; Criswell, Cameron; Wicky, Basile I M; Vafeados, Dionne; Sanchez, Mariana Garcia; Kim, Ho Min; Torres, Susana Vázquez; Chan, Sidney; Sun, Shirley M; Spear, Timothy; Sun, Yi; O'Reilly, Keelan; Maris, John M; Sgourakis, Nikolaos G; Melnyk, Roman A; Liu, Chang C; Baker, David

The PfRCR complex bridges malaria parasite and erythrocyte during invasion

PfRCR 复合物在入侵过程中充当疟原虫和红细胞之间的桥梁

Brendan Farrell, Nawsad Alam #, Melissa N Hart #, Abhishek Jamwal, Robert J Ragotte, Hannah Walters-Morgan, Simon J Draper, Ellen Knuepfer, Matthew K Higgins

Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists

靶向条件扩散产生强效的TNFR超家族拮抗剂和激动剂

Glögl, Matthias; Krishnakumar, Aditya; Ragotte, Robert J; Goreshnik, Inna; Coventry, Brian; Bera, Asim K; Kang, Alex; Joyce, Emily; Ahn, Green; Huang, Buwei; Yang, Wei; Chen, Wei; Sanchez, Mariana Garcia; Koepnick, Brian; Baker, David

Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex

开发针对关键 RH5-CyRPA-RIPR 入侵复合物的改良血液阶段疟疾疫苗

Barnabas G Williams #, Lloyd D W King #, David Pulido, Doris Quinkert, Amelia M Lias, Sarah E Silk, Robert J Ragotte, Hannah Davies, Jordan R Barrett, Kirsty McHugh, Cassandra A Rigby, Daniel G W Alanine, Lea Barfod, Michael W Shea, Li An Cowley, Rebecca A Dabbs, David J Pattinson, Alexander D Dougl

Designed miniproteins potently inhibit and protect against MERS-CoV

设计的微型蛋白可有效抑制和预防 MERS-CoV

Robert J Ragotte, M Alejandra Tortorici, Nicholas J Catanzaro, Amin Addetia, Brian Coventry, Heather M Froggatt, Jimin Lee, Cameron Stewart, Jack T Brown, Inna Goreshnik, Jeremiah N Sims, Lukas F Milles, Basile I M Wicky, Matthias Glögl, Stacey Gerben, Alex Kang, Asim K Bera, William Sharkey, Alexan