Transdifferentiation occurs without resetting development-specific DNA methylation, a key determinant of full-function cell identity.
转分化过程中不会重置发育特异性 DNA 甲基化,而 DNA 甲基化是决定细胞完全功能的关键因素
期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2411352121
Radwan Ahmed, Eccleston Jason, Sabag Ofra, Marcus Howard, Sussman Jonathan, Ouro Alberto, Rahamim Moran, Azagury Meir, Azria Batia, Stanger Ben Z, Cedar Howard, Buganim Yosef