日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Computational design of nanomolar-binding antibodies specific to multiple SARS-CoV-2 variants by engineering a specificity switch of antibody 80R using RosettaAntibodyDesign (RAbD) results in potential generalizable therapeutic antibodies for novel SARS-CoV-2 virus

通过使用 RosettaAntibodyDesign (RAbD) 设计抗体 80R 的特异性开关,计算设计针对多种 SARS-CoV-2 变体的纳摩尔结合抗体,从而为新型 SARS-CoV-2 病毒提供潜在的可推广治疗性抗体

Nancy E Hernandez, Wojciech Jankowski, Rahel Frick, Simon P Kelow, Joseph H Lubin, Vijaya Simhadri, Jared Adolf-Bryfogle, Sagar D Khare, Roland L Dunbrack Jr, Jeffrey J Gray, Zuben E Sauna

Biophysical differences in IgG1 Fc-based therapeutics relate to their cellular handling, interaction with FcRn and plasma half-life

IgG1 Fc 基疗法的生物物理差异与其细胞处理、与 FcRn 的相互作用以及血浆半衰期有关

Torleif Tollefsrud Gjølberg, Rahel Frick #, Simone Mester #, Stian Foss, Algirdas Grevys, Lene Støkken Høydahl, Øystein Kalsnes Jørstad, Tilman Schlothauer, Inger Sandlie, Morten C Moe, Jan Terje Andersen

Antibody variable sequences have a pronounced effect on cellular transport and plasma half-life

抗体可变区序列对细胞转运和血浆半衰期有显著影响。

Algirdas Grevys ,Rahel Frick ,Simone Mester ,Karine Flem-Karlsen ,Jeannette Nilsen ,Stian Foss ,Kine Marita Knudsen Sand ,Thomas Emrich ,Jens Andre Alexander Fischer ,Victor Greiff ,Inger Sandlie ,Tilman Schlothauer ,Jan Terje Andersen

Affinity maturation of TCR-like antibodies using phage display guided by structural modeling

利用结构建模指导噬菌体展示实现 TCR 样抗体的亲和力成熟

Rahel Frick, Lene S Høydahl, Ina Hodnebrug, Erik S Vik, Bjørn Dalhus, Ludvig M Sollid, Jeffrey J Gray, Inger Sandlie, Geir Åge Løset

A high-affinity human TCR-like antibody detects celiac disease gluten peptide-MHC complexes and inhibits T cell activation

高亲和力人类 TCR 样抗体可检测乳糜泻麸质肽-MHC 复合物并抑制 T 细胞活化

Rahel Frick, Lene S Høydahl, Jan Petersen, M Fleur du Pré, Shraddha Kumari, Grete Berntsen, Alisa E Dewan, Jeliazko R Jeliazkov, Kristin S Gunnarsen, Terje Frigstad, Erik S Vik, Carmen Llerena, Knut E A Lundin, Sheraz Yaqub, Jørgen Jahnsen, Jeffrey J Gray, Jamie Rossjohn, Ludvig M Sollid, Inger Sand

Plasma Cells Are the Most Abundant Gluten Peptide MHC-expressing Cells in Inflamed Intestinal Tissues From Patients With Celiac Disease

浆细胞是乳糜泻患者发炎肠道组织中最丰富的表达麸质肽 MHC 的细胞

Lene Støkken Høydahl, Lisa Richter, Rahel Frick, Omri Snir, Kristin Støen Gunnarsen, Ole J B Landsverk, Rasmus Iversen, Jeliazko R Jeliazkov, Jeffrey J Gray, Elin Bergseng, Stian Foss, Shuo-Wang Qiao, Knut E A Lundin, Jørgen Jahnsen, Frode L Jahnsen, Inger Sandlie, Ludvig M Sollid, Geir Åge Løset0

A TCRα framework-centered codon shapes a biased T cell repertoire through direct MHC and CDR3β interactions

以 TCRα 框架为中心的密码子通过直接的 MHC 和 CDR3β 相互作用形成有偏向的 T 细胞库

Kristin Støen Gunnarsen, Lene Støkken Høydahl, Louise Fremgaard Risnes, Shiva Dahal-Koirala, Ralf Stefan Neumann, Elin Bergseng, Terje Frigstad, Rahel Frick, M Fleur du Pré, Bjørn Dalhus, Knut Ea Lundin, Shuo-Wang Qiao, Ludvig M Sollid, Inger Sandlie, Geir Åge Løset