The NAE inhibitor pevonedistat interacts with the HDAC inhibitor belinostat to target AML cells by disrupting the DDR.
NAE 抑制剂 pevonedistat 与 HDAC 抑制剂 belinostat 相互作用,通过破坏 DDR 来靶向 AML 细胞
期刊:Blood
影响因子:23.1
doi:10.1182/blood-2015-06-653717
Zhou Liang, Chen Shuang, Zhang Yu, Kmieciak Maciej, Leng Yun, Li Lihong, Lin Hui, Rizzo Kathryn A, Dumur Catherine I, Ferreira-Gonzalez Andrea, Rahmani Mohamed, Povirk Lawrence, Chalasani Sri, Berger Allison J, Dai Yun, Grant Steven