日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A small molecule VDAC ligand inhibits ERAD and induces selective cancer cell death via disruption of calcium homeostasis.

一种小分子 VDAC 配体通过破坏钙稳态抑制 ERAD 并诱导选择性癌细胞死亡。

Yan Wenjing, Talley Daniel C, Syam Antara, Danchik Carina, Zhong Yongwang, Zhang Xianzheng, Liu Xiaoying, Baljinnyam Bolormaa, Kales Stephen C, Cyr Matthew G, Fang Yuhong, Zakharov Alexey V, Hu Xin, Niehoff Taylor, Xu Tuan, Qu Yanyan, Yang Allison, Courouble Valentine V, Yao Qin, Simeonov Anton, Huang Ruili, Rostovtseva Tatiana K, Bezrukov Sergey M, LeClair Christopher A, Egan Josephine M, Wang Hua, Tao Dingyin, Rai Ganesha, Henderson Mark J, Fang Shengyun

Targeting of interaction between BB0323-BB0238 informs new paradigms in Lyme disease therapeutics

靶向研究BB0323-BB0238之间的相互作用为莱姆病治疗提供了新的范式

Bista, Sandhya; Brangulis, Kalvis; Bhattachan, Bibek; Foor, Shelby D; Ronzetti, Michael H; Jain, Sankalp; Miller, Jenna; Subramanion, Jothy Lachumy; Kitsou, Chrysoula; Rana, Vipin S; Rai, Ganesha; Zakharov, Alexey V; Simeonov, Anton; Baljinnyam, Bolormaa; Pal, Utpal

SELECTIVE ACTIVATION OF GIRK POTASSIUM CHANNELS REDUCES BEHAVIORAL AND BRAIN RESPONSES TO ETHANOL IN MICE

选择性激活GIRK钾通道可降低小鼠对乙醇的行为和脑反应

Taura, Jaume; Marrazzo, Arianna; Son, Se In; Rai, Ganesha; Kreifeldt, Max; Contet, Candice; Slesinger, Paul A

KDM4C inhibition blocks tumor growth in basal breast cancer by promoting cathepsin L-mediated histone H3 cleavage.

KDM4C 抑制剂通过促进组织蛋白酶 L 介导的组蛋白 H3 裂解来阻断基底型乳腺癌的肿瘤生长

Li Zheqi, Peluffo Guillermo, Stevens Laura E, Qiu Xintao, Seehawer Marco, Tawawalla Amatullah, Huang Xiao-Yun, Egri Shawn B, Raval Shaunak, McFadden Maeve, D'Santos Clive S, Papachristou Eva, Kingston Natalie L, Nishida Jun, Evans Kyle E, Seo Ji-Heui, Clement Kendell, Temko Daniel, Ekram Muhammad, Li Rong, Rees Matthew G, Ronan Melissa M, Roth Jennifer A, Simeonov Anton, Kales Stephen C, Rai Ganesha, Lal-Nag Madhu, Maloney David J, Jadhav Ajit, Michor Franziska, Meissner Alex, Balko Justin M, Carroll Jason S, Freedman Matthew L, Jaffe Jacob D, Papanastasiou Malvina, Long Henry W, Polyak Kornelia

Discovery and Optimization of LATS1 and LATS2 Kinase Inhibitors for Use in Regenerative Medicine

LATS1和LATS2激酶抑制剂的发现和优化及其在再生医学中的应用

Morris, Patrick J; Duveau, Damien Y; Ceribelli, Michele; Tosto, Frances Anne; Love, Dara N; Scherer, Bridget S; Tao, Dingyin; Fang, Yuhong; Evsen, Lale; Kotler, Samuel A; LeClair, Christopher A; Rai, Ganesha; Thomas, Craig J; Hoyt, Scott B

Mass spectrometry-guided discovery of novel GCPII inhibitor scaffolds

质谱引导下新型GCPII抑制剂骨架的发现

Wiseman, Robyn; Thomas, Ajit G; Janiszewski, John; Hoxie, Nate; Lee, Chae Bin; Wu, Ying; Tsukamoto, Takashi; Ye, Lin; Ronzetti, Michael; Shrimp, Jonathan H; Adderley, Davina; Rai, Ganesha; Rais, Rana; Alt, Jesse; Hall, Matthew D; Hu, Xin; Kales, Stephen C; Slusher, Barbara S

Borrelial phosphomannose isomerase as a cell surface localized protein that retains enzymatic activity and promotes host-pathogen interaction

伯氏疏螺旋体磷酸甘露糖异构酶是一种定位于细胞表面的蛋白质,它保留了酶活性并促进宿主-病原体相互作用。

Dutta, Shraboni; Rana, Vipin S; Backstedt, Brian T; Shakya, Anil K; Kitsou, Chrysoula; Yas, Ozlem B; Smith, Alexis A; Ronzetti, Michael H; Lipman, Rachel M; Araujo-Aris, Sarai; Yang, Xiuli; Rai, Ganesha; Lin, Yi-Pin; Herzberg, Osnat; Pal, Utpal

A selective small-molecule agonist of G protein-gated inwardly-rectifying potassium channels reduces epileptiform activity in mouse models of tumor-associated and provoked seizures

选择性小分子G蛋白门控内向整流钾通道激动剂可降低肿瘤相关和诱发性癫痫小鼠模型中的癫痫样活动。

Rifkin, Robert A; Wu, Xiaoping; Pereira, Brianna; Gill, Brian Ja; Merricks, Edward M; Michalak, Andrew J; Goldberg, Alexander R; Humala, Nelson; Dovas, Athanassios; Rai, Ganesha; McKhann, Guy M; Slesinger, Paul A; Canoll, Peter; Schevon, Catherine

Integrated Approach of Machine Learning and High-Throughput Screening to Identify Chemical Probe Candidates Targeting Aldehyde Dehydrogenases.

机器学习与高通量筛选相结合的方法来识别靶向醛脱氢酶的化学探针候选物。

Yasgar Adam, Jain Sankalp, Davies Marissa, Danchik Carina, Niehoff Taylor, Ran Jing, Rai Ganesha, Yang Shyh-Ming, Simeonov Anton, Zakharov Alexey V, Martinez Natalia J

Uncovering the isoform-resolution kinetic landscape of nonsense-mediated mRNA decay with EZbakR

利用 EZbakR 揭示无义介导的 mRNA 衰变的异构体分辨率动力学图谱

Mabin, Justin W; Vock, Isaac W; Machyna, Martin; Haque, Nazmul; Thakran, Poonam; Zhang, Alexandra; Rai, Ganesha; Leibler, Isabelle Nathalie-Marie; Inglese, James; Simon, Matthew D; Hogg, J Robert