日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Phase 1 Assessment of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of (2R,6R)-Hydroxynorketamine in Healthy Volunteers

(2R,6R)-羟基去甲氯胺酮在健康志愿者中的安全性、耐受性、药代动力学和药效学的I期评估

Raja, Shruti M; Guptill, Jeffrey T; Mack, Michelle; Peterson, Marni; Byard, Stephen; Twieg, Robert; Jordan, Lynn; Rich, Natalie; Castledine, Richard; Bourne, Samuel; Wilmshurst, Martin; Oxendine, Sarah; Avula, Satya G C; Zuleta, Helen; Quigley, Paul; Lawson, Sheila; McQuaker, Stephen J; Ahmadkhaniha, Reza; Appelbaum, Lawrence G; Kowalski, Kevin; Barksdale, Chineta T; Gufford, Brandon T; Awan, Asaad; Sancho, Alfredo R; Moore, Max C; Berrada, Karim; Cogan, Gregory B; DeLaRosa, Jesse; Radcliffe, Jeanne; Pao, Maryland; Kennedy, Michelle; Lawrence, Quentin; Goldfeder, Lisa; Amanfo, Leslie; Zanos, Panos; Gilbert, Jessica R; Morris, Patrick J; Moaddel, Ruin; Gould, Todd D; Zarate, Carlos A Jr; Thomas, Craig J

Experience of Daily Life with Generalized Myasthenia Gravis: A Qualitative Investigation and Assessment of Instrument Content Validity

重症肌无力患者日常生活体验:一项定性调查和工具内容效度评估

Hartford, Christopher A; Sherman, Steven A; Karantzoulis, Stella; Guillemin, Isabelle; Phinney, Michael G; Kelly, Kimberly L; Negron, Kayla E; Raja, Shruti M; Rofail, Diana

Adverse Reactions in a Phase 1 Trial of the Anti-Malarial DM1157: An Example of Pharmacokinetic Modeling and Simulation Guiding Clinical Trial Decisions

抗疟疾药物DM1157 I期临床试验中的不良反应:药代动力学建模和模拟指导临床试验决策的实例

Balevic, Stephen J; Raja, Shruti M; Randell, Rachel; Deye, Gregory A; Conrad, Thomas; Nakamura, Aya; Peyton, David H; Shotwell, Sandra; Liebman, Katherine; Cohen-Wolkowiez, Michael; Guptill, Jeffrey T

Safety of Ceftazidime-Avibactam in Combination with Aztreonam (COMBINE) in a Phase I, Open-Label Study in Healthy Adult Volunteers

在健康成年志愿者中开展的 I 期开放标签研究评估头孢他啶-阿维巴坦联合氨曲南(COMBINE)的安全性

Lodise, Thomas P; O'Donnell, J Nicholas; Raja, Shruti; Guptill, Jeffrey T; Zaharoff, Smitha; Schwager, Nyssa; Fowler, Vance G Jr; Beresnev, Tatiana; Wall, Alison; Wiegand, Katherine; Serti Chrisos, Elisavet; Balevic, Stephen; Chambers, Henry F

Pharmacokinetics of Ceftazidime-Avibactam in Combination with Aztreonam (COMBINE) in a Phase 1, Open-Label Study of Healthy Adults

在健康成年人中开展的 1 期开放标签研究中,头孢他啶-阿维巴坦联合氨曲南 (COMBINE) 的药代动力学研究

Lodise, Thomas P; O'Donnell, J Nicholas; Balevic, Stephen; Liu, Xing; Gu, Kenan; George, Jomy; Raja, Shruti; Guptill, Jeffrey T; Zaharoff, Smitha; Schwager, Nyssa; Fowler, Vance G Jr; Wall, Alison; Wiegand, Katherine; Chambers, Henry F

233. Safety of Ceftazidime-Avibactam (CZA) in Combination with Aztreonam (ATM) in a Phase I, Open-Label Study in Healthy Adult Subjects (COMBINE)

233. 在健康成年受试者中开展的 I 期开放标签研究 (COMBINE) 评估头孢他啶-阿维巴坦 (CZA) 与氨曲南 (ATM) 联合用药的安全性

Manabe, Yukari C; Zawedde-Muyanja, Stella; Burnett, Sarah M; Mugabe, Frank; Naikoba, Sarah; Coutinho, Alex; Lodise, Thomas Jr; Nicholas O’Donnell, J; Raja, Shruti; Balevic, Stephen; Guptill, Jeffrey; Schwager, Nyssa; Zaharoff, Smitha; Fowler, Vance G Jr; Ghazaryan, Varduhi; Beresnev, Tatiana; wall, Alison; Wiegand, Katherine; Chambers, Henry

Reduced plasmablast frequency is associated with seronegative myasthenia gravis

浆细胞频率降低与血清阴性重症肌无力相关

Guptill, Jeffrey T; Barfield, Richard; Chan, Cliburn; Russo, Melissa A; Emmett, Doug; Raja, Shruti; Massey, Janice M; Juel, Vern C; Hobson-Webb, Lisa D; Gable, Karissa L; Gonzalez, Natalia; Hammett, Alex; Howard, James F Jr; Chopra, Manisha; Kaminski, Henry J; Siddiqi, Zaeem A; Migdal, Mattingly; Yi, John S

Quantitative muscle ultrasound and electrical impedance myography in late onset Pompe disease: A pilot study of reliability, longitudinal change and correlation with function

定量肌肉超声和电阻抗肌电图在晚发型庞贝病中的应用:一项关于可靠性、纵向变化及与功能相关性的初步研究

Hobson-Webb, Lisa D; Zwelling, Paul J; Raja, Shruti S; Pifer, Ashley N; Kishnani, Priya S

Inhibition of the transcription factor ROR-γ reduces pathogenic Th17 cells in acetylcholine receptor antibody positive myasthenia gravis

抑制转录因子ROR-γ可减少乙酰胆碱受体抗体阳性重症肌无力中的致病性Th17细胞

Yi, John S; Russo, Melissa A; Raja, Shruti; Massey, Janice M; Juel, Vern C; Shin, Jay; Hobson-Webb, Lisa D; Gable, Karissa; Guptill, Jeffrey T

Imbalance in T follicular helper cells producing IL-17 promotes pro-inflammatory responses in MuSK antibody positive myasthenia gravis.

产生 IL-17 的 T 滤泡辅助细胞失衡会促进 MuSK 抗体阳性重症肌无力患者的促炎反应

Li Yingkai, Guptill Jeffrey T, Russo Melissa A, Howard James F Jr, Massey Janice M, Juel Vern C, Hobson-Webb Lisa D, Emmett Doug, Chopra Manisha, Raja Shruti, Liu Weibin, Yi John S