日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Preclinical characterization of AZD1163, a first-in-class anti-PAD2/4 bispecific antibody for the treatment of rheumatoid arthritis.

AZD1163 的临床前表征,AZD1163 是一种用于治疗类风湿性关节炎的首创抗 PAD2/4 双特异性抗体。

Sims Gary P, Scaletta Lacie, Andrews John, Sims Dorothy A, Strain Martin, Sigurdardottir Anna, Kuriakose Teneema, England Elizabeth, Rajasinghe Lichchavi, Jiang Fanyi, Xiong Ximing, Neal Frances, Vinall Lisa, Newton Philip, Boger Elin, Kim Chong, Dahlbäck Helena, Prothon Susanne, Leander Jacob, Darrah Erika, Collins Mia, Douglas Garry, White Nicholas, Day Katie, Vousden Katherine A, Huntington Catherine E, Close David

Dietary docosahexaenoic acid supplementation inhibits acute pulmonary transcriptional and autoantibody responses to a single crystalline silica exposure in lupus-prone mice

膳食补充二十二碳六烯酸可抑制易患狼疮的小鼠对单晶二氧化硅暴露的急性肺转录和自身抗体反应

Preeti S Chauhan #, Abby D Benninghoff #, Olivia K Favor, James G Wagner, Ryan P Lewandowski, Lichchavi D Rajasinghe, Quan-Zhen Li, Jack R Harkema, James J Pestka

Subchronic intranasal lipopolysaccharide exposure induces pulmonary autoimmunity and glomerulonephritis in NZBWF1 mice.

亚慢性鼻内脂多糖暴露可诱发 NZBWF1 小鼠的肺部自身免疫和肾小球肾炎

Heine Lauren K, Rajasinghe Lichchavi D, Wagner James G, Lewandowski Ryan P, Li Quan-Zhen, Richardson Alexa L, Tindle Ashleigh N, Shareef Jenan J, Harkema Jack R, Pestka James J

Translation, cross-cultural adaptation, and validation of the Duke Activity Status Index (DASI) to Sinhala language

将杜克活动状态指数(DASI)翻译、跨文化适应并验证为僧伽罗语

Ranasinghe, C; Kariyawasam, K; Liyanage, J; Walpita, Y; Rajasinghe, U; Abayadeera, A; Chandrasinghe, P; Gunasekara, M; Kumarage, S; De Silva, M; Ranathunga, K; Deen, K; Ismail, H

Crystalline silica-induced proinflammatory eicosanoid storm in novel alveolar macrophage model quelled by docosahexaenoic acid supplementation.

新型肺泡巨噬细胞模型中结晶二氧化硅诱发的促炎性二十碳酸风暴可通过补充二十二碳六烯酸来抑制

Favor Olivia K, Rajasinghe Lichchavi D, Wierenga Kathryn A, Maddipati Krishna R, Lee Kin Sing Stephen, Olive Andrew J, Pestka James J

Comparative effects of human-equivalent low, moderate, and high dose oral prednisone intake on autoimmunity and glucocorticoid-related toxicity in a murine model of environmental-triggered lupus

在环境诱发狼疮的小鼠模型中,比较人类等效低、中、高剂量口服泼尼松对自身免疫和糖皮质激素相关毒性的影响

Heine, Lauren K; Benninghoff, Abby D; Ross, Elizabeth A; Rajasinghe, Lichchavi D; Wagner, James G; Lewandowski, Ryan P; Richardson, Alexa L; Li, Quan-Zhen; Buchweitz, John P; Zyskowski, Justin; Tindle, Ashleigh N; Skedel, Anna E; Chargo, Nicholas J; McCabe, Laura R; Harkema, Jack R; Pestka, James J

Silica Induction of Diverse Inflammatory Proteome in Lungs of Lupus-Prone Mice Quelled by Dietary Docosahexaenoic Acid Supplementation.

二氧化硅诱导狼疮易感小鼠肺部出现多种炎症蛋白组,而膳食补充二十二碳六烯酸可抑制这种炎症蛋白组

Rajasinghe Lichchavi D, Bates Melissa A, Benninghoff Abby D, Wierenga Kathryn A, Harkema Jack R, Pestka James J

Omega-3 Polyunsaturated Fatty Acid Intervention Against Established Autoimmunity in a Murine Model of Toxicant-Triggered Lupus

Omega-3 多不饱和脂肪酸干预对抗毒物诱发狼疮的小鼠模型中已建立的自身免疫

James J Pestka, Peyman Akbari, Kathryn A Wierenga, Melissa A Bates, Kristen N Gilley, James G Wagner, Ryan P Lewandowski, Lichchavi D Rajasinghe, Preeti S Chauhan, Adam L Lock, Quan-Zhen Li, Jack R Harkema

Requisite Omega-3 HUFA Biomarker Thresholds for Preventing Murine Lupus Flaring

预防小鼠狼疮发作所需的ω-3高不饱和脂肪酸生物标志物阈值

Wierenga, Kathryn A; Strakovsky, Rita S; Benninghoff, Abby D; Rajasinghe, Lichchavi D; Lock, Adam L; Harkema, Jack R; Pestka, James J

Omega-3 Docosahexaenoic Acid (DHA) Impedes Silica-Induced Macrophage Corpse Accumulation by Attenuating Cell Death and Potentiating Efferocytosis.

Omega-3二十二碳六烯酸(DHA)通过减弱细胞死亡和增强胞吞作用来抑制二氧化硅诱导的巨噬细胞尸体积累

Rajasinghe Lichchavi D, Chauhan Preeti S, Wierenga Kathryn A, Evered Augustus O, Harris Shamya N, Bates Melissa A, Gavrilin Mikhail A, Pestka James J