日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Glu-urea-Lys Ligand-conjugated Lipid Nanoparticle/siRNA System Inhibits Androgen Receptor Expression In Vivo.

Glu-urea-Lys配体偶联脂质纳米颗粒/siRNA系统在体内抑制雄激素受体表达

Lee Justin B, Zhang Kaixin, Tam Yuen Yi C, Quick Joslyn, Tam Ying K, Lin Paulo Jc, Chen Sam, Liu Yan, Nair Jayaprakash K, Zlatev Ivan, Rajeev Kallanthottathil G, Manoharan Muthiah, Rennie Paul S, Cullis Pieter R

Allele-selective inhibition of mutant atrophin-1 expression by duplex and single-stranded RNAs.

通过双链和单链RNA对突变型萎缩蛋白-1表达进行等位基因选择性抑制

Hu Jiaxin, Liu Jing, Narayanannair K Jayaprakash, Lackey Jeremy G, Kuchimanchi Satya, Rajeev Kallanthottathil G, Manoharan Muthiah, Swayze Eric E, Lima Walt F, Prakash Thazha P, Xiang Qin, Martinez Carlos, Corey David R

Biodegradable lipids enabling rapidly eliminated lipid nanoparticles for systemic delivery of RNAi therapeutics

可生物降解的脂质能够使脂质纳米颗粒快速清除,从而实现RNAi疗法的全身递送。

Maier, Martin A; Jayaraman, Muthusamy; Matsuda, Shigeo; Liu, Ju; Barros, Scott; Querbes, William; Tam, Ying K; Ansell, Steven M; Kumar, Varun; Qin, June; Zhang, Xuemei; Wang, Qianfan; Panesar, Sue; Hutabarat, Renta; Carioto, Mary; Hettinger, Julia; Kandasamy, Pachamuthu; Butler, David; Rajeev, Kallanthottathil G; Pang, Bo; Charisse, Klaus; Fitzgerald, Kevin; Mui, Barbara L; Du, Xinyao; Cullis, Pieter; Madden, Thomas D; Hope, Michael J; Manoharan, Muthiah; Akinc, Akin

Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles

聚乙二醇脂质解吸速率对siRNA脂质纳米颗粒药代动力学和药效学的影响

Mui, Barbara L; Tam, Ying K; Jayaraman, Muthusamy; Ansell, Steven M; Du, Xinyao; Tam, Yuen Yi C; Lin, Paulo Jc; Chen, Sam; Narayanannair, Jayaprakash K; Rajeev, Kallanthottathil G; Manoharan, Muthiah; Akinc, Akin; Maier, Martin A; Cullis, Pieter; Madden, Thomas D; Hope, Michael J

Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo

最大程度提高siRNA脂质纳米颗粒在体内肝脏基因沉默中的效力

Jayaraman, Muthusamy; Ansell, Steven M; Mui, Barbara L; Tam, Ying K; Chen, Jianxin; Du, Xinyao; Butler, David; Eltepu, Laxman; Matsuda, Shigeo; Narayanannair, Jayaprakash K; Rajeev, Kallanthottathil G; Hafez, Ismail M; Akinc, Akin; Maier, Martin A; Tracy, Mark A; Cullis, Pieter R; Madden, Thomas D; Manoharan, Muthiah; Hope, Michael J

Unique gene-silencing and structural properties of 2'-fluoro-modified siRNAs

2'-氟修饰siRNA独特的基因沉默和结构特性

Manoharan, Muthiah; Akinc, Akin; Pandey, Rajendra K; Qin, June; Hadwiger, Philipp; John, Matthias; Mills, Kathy; Charisse, Klaus; Maier, Martin A; Nechev, Lubomir; Greene, Emily M; Pallan, Pradeep S; Rozners, Eriks; Rajeev, Kallanthottathil G; Egli, Martin

Multivalent cyclic RGD conjugates for targeted delivery of small interfering RNA

用于靶向递送小干扰RNA的多价环状RGD缀合物

Alam, Md Rowshon; Ming, Xin; Fisher, Michael; Lackey, Jeremy G; Rajeev, Kallanthottathil G; Manoharan, Muthiah; Juliano, Rudy L

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

用于递送RNAi疗法的脂质样材料组合库

Akinc, Akin; Zumbuehl, Andreas; Goldberg, Michael; Leshchiner, Elizaveta S; Busini, Valentina; Hossain, Naushad; Bacallado, Sergio A; Nguyen, David N; Fuller, Jason; Alvarez, Rene; Borodovsky, Anna; Borland, Todd; Constien, Rainer; de Fougerolles, Antonin; Dorkin, J Robert; Narayanannair Jayaprakash, K; Jayaraman, Muthusamy; John, Matthias; Koteliansky, Victor; Manoharan, Muthiah; Nechev, Lubomir; Qin, June; Racie, Timothy; Raitcheva, Denitza; Rajeev, Kallanthottathil G; Sah, Dinah W Y; Soutschek, Jürgen; Toudjarska, Ivanka; Vornlocher, Hans-Peter; Zimmermann, Tracy S; Langer, Robert; Anderson, Daniel G

Specificity, duplex degradation and subcellular localization of antagomirs

反义寡核苷酸的特异性、双链降解和亚细胞定位

Krützfeldt, Jan; Kuwajima, Satoru; Braich, Ravi; Rajeev, Kallanthottathil G; Pena, John; Tuschl, Thomas; Manoharan, Muthiah; Stoffel, Markus

Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme

含核糖二氟甲苯酰核苷酸的寡核糖核苷酸的晶体结构、稳定性及体外RNAi活性:揭示人RISC Ago2酶的底物需求

Li, Feng; Pallan, Pradeep S; Maier, Martin A; Rajeev, Kallanthottathil G; Mathieu, Steven L; Kreutz, Christoph; Fan, Yupeng; Sanghvi, Jayodita; Micura, Ronald; Rozners, Eriks; Manoharan, Muthiah; Egli, Martin