日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

2'-deoxy-ADPR activates human TRPM2 faster than ADPR and thereby induces higher currents at physiological Ca2+ concentrations

2'-脱氧-ADPR 比 ADPR 更快地激活人类 TRPM2,从而在生理 Ca2+ 浓度下诱导更高的电流

Jelena Pick, Simon Sander, Stefanie Etzold, Anette Rosche, Henning Tidow, Andreas H Guse, Ralf Fliegert

Potential role of the bitter taste receptor T2R14 in the prolonged survival and enhanced chemoresponsiveness induced by apigenin

苦味受体 T2R14 在芹菜素诱导的延长存活时间和增强化学反应性中的潜在作用

Louisa Stern, Lukas Fabian Boehme, Mara Rebecca Goetz, Christine Nitschke, Anastasios Giannou, Tao Zhang, Cenap Güngör, Matthias Reeh, Jakob Robert Izbicki, Ralf Fliegert, Anne Hausen, Nathalia Giese, Thilo Hackert, Masha Y Niv, Stefan Heinrich, Matthias Martin Gaida #, Tarik Ghadban #

The crystal structure of TRPM2 MHR1/2 domain reveals a conserved Zn2+ -binding domain essential for structural integrity and channel activity

TRPM2 MHR1/2结构域的晶体结构揭示了一个保守的Zn2+结合结构域,该结构域对于结构完整性和通道活性至关重要。

Simon Sander ,Jelena Pick ,Ellen Gattkowski ,Ralf Fliegert ,Henning Tidow

cADPR Does Not Activate TRPM2

cADPR 不激活 TRPM2

Winnie Maria Riekehr, Simon Sander, Jelena Pick, Henning Tidow, Andreas Bauche, Andreas H Guse, Ralf Fliegert

CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression

CD73 介导的 CD8 T 细胞衍生的细胞外囊泡产生腺苷是免疫抑制的内在机制

Enja Schneider #, Riekje Winzer #, Anne Rissiek, Isabell Ricklefs, Catherine Meyer-Schwesinger, Franz L Ricklefs, Andreas Bauche, Jochen Behrends, Rudolph Reimer, Santra Brenna, Hauke Wasielewski, Melchior Lauten, Björn Rissiek, Berta Puig, Filippo Cortesi, Tim Magnus, Ralf Fliegert, Christa E Mülle

Analysis of ligand binding and resulting conformational changes in pyrophosphatase NUDT9

焦磷酸酶 NUDT9 中配体结合及其导致的构象变化的分析

Ellen Gattkowski, Trevor J Rutherford, Franziska Möckl, Andreas Bauche, Simon Sander, Ralf Fliegert, Henning Tidow

Daratumumab and Nanobody-Based Heavy Chain Antibodies Inhibit the ADPR Cyclase but not the NAD+ Hydrolase Activity of CD38-Expressing Multiple Myeloma Cells

达雷木单抗和基于纳米抗体的重链抗体可抑制表达 CD38 的多发性骨髓瘤细胞的 ADPR 环化酶,但不抑制 NAD+ 水解酶活性

Natalie Baum, Ralf Fliegert, Andreas Bauche, Julia Hambach, Stephan Menzel, Friedrich Haag, Peter Bannas, Friedrich Koch-Nolte

Novel CaM-binding motif in its NudT9H domain contributes to temperature sensitivity of TRPM2

NudT9H 结构域中的新型 CaM 结合基序有助于 TRPM2 的温度敏感性

Ellen Gattkowski, Anke Johnsen, Andreas Bauche, Franziska Möckl, Frederike Kulow, Maria Garcia Alai, Trevor J Rutherford, Ralf Fliegert, Henning Tidow

2'-Deoxyadenosine 5'-diphosphoribose is an endogenous TRPM2 superagonist

2'-脱氧腺苷 5'-二磷酸核糖是一种内源性 TRPM2 超激动剂

Ralf Fliegert, Andreas Bauche, Adriana-Michelle Wolf Pérez, Joanna M Watt, Monika D Rozewitz, Riekje Winzer, Mareike Janus, Feng Gu, Annette Rosche, Angelika Harneit, Marianne Flato, Christelle Moreau, Tanja Kirchberger, Valerie Wolters, Barry V L Potter, Andreas H Guse

Nanobodies effectively modulate the enzymatic activity of CD38 and allow specific imaging of CD38+ tumors in mouse models in vivo

纳米抗体可有效调节 CD38 的酶活性,并允许在小鼠模型中对 CD38+ 肿瘤进行体内特异性成像

William Fumey, Julia Koenigsdorf, Valentin Kunick, Stephan Menzel, Kerstin Schütze, Mandy Unger, Levin Schriewer, Friedrich Haag, Gerhard Adam, Anna Oberle, Mascha Binder, Ralf Fliegert, Andreas Guse, Yong Juan Zhao, Hon Cheung Lee, Fabio Malavasi, Fernando Goldbaum, Rob van Hegelsom, Catelijne Stor