日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Combination of ONC201 and TLY012 induces selective, synergistic apoptosis in vitro and significantly delays PDAC xenograft growth in vivo

ONC201 和 TLY012 联合用药可在体外诱导选择性、协同性细胞凋亡,并显著延缓体内 PDAC 异种移植瘤的生长。

Jhaveri, Aakash V; Zhou, Lanlan; Ralff, Marie D; Lee, Young S; Navaraj, Arunasalam; Carneiro, Benedito A; Safran, Howard; Prabhu, Varun V; Ross, Eric A; Lee, Seulki; El-Deiry, Wafik S

Antitumorigenic effect of combination treatment with ONC201 and TRAIL in endometrial cancer in vitro and in vivo

ONC201和TRAIL联合治疗对子宫内膜癌的体外和体内抗肿瘤作用

Jocelyn E Ray ,Marie D Ralff ,Aakash Jhaveri ,Lanlan Zhou ,David T Dicker ,Eric A Ross ,Wafik S El-Deiry

ONC201 and imipridones: Anti-cancer compounds with clinical efficacy

ONC201 和咪唑吡酮:具有临床疗效的抗癌化合物

Prabhu, Varun Vijay; Morrow, Sara; Rahman Kawakibi, Abed; Zhou, Lanlan; Ralff, Marie; Ray, Jocelyn; Jhaveri, Aakash; Ferrarini, Isacco; Lee, Young; Parker, Cassandra; Zhang, Yiqun; Borsuk, Robyn; Chang, Wen-I; Honeyman, Joshua N; Tavora, Fabio; Carneiro, Benedito; Raufi, Alexander; Huntington, Kelsey; Carlsen, Lindsey; Louie, Anna; Safran, Howard; Seyhan, Attila A; Tarapore, Rohinton S; Schalop, Lee; Stogniew, Martin; Allen, Joshua E; Oster, Wolfgang; El-Deiry, Wafik S

TRAIL receptor agonists convert the response of breast cancer cells to ONC201 from anti-proliferative to apoptotic

TRAIL 受体激动剂将乳腺癌细胞对 ONC201 的反应从抗增殖转变为凋亡

Marie D Ralff, Aakash Jhaveri, Jocelyn E Ray, Lanlan Zhou, Avital Lev, Kerry S Campbell, David T Dicker, Eric A Ross, Wafik S El-Deiry

Dose intensification of TRAIL-inducing ONC201 inhibits metastasis and promotes intratumoral NK cell recruitment

增加 TRAIL 诱导剂 ONC201 的剂量可抑制转移并促进肿瘤内 NK 细胞募集。

Jessica Wagner ,C Leah Kline ,Lanlan Zhou ,Kerry S Campbell ,Alexander W MacFarlane ,Anthony J Olszanski ,Kathy Q Cai ,Harvey H Hensley ,Eric A Ross ,Marie D Ralff ,Andrew Zloza ,Charles B Chesson ,Jenna H Newman ,Howard Kaufman ,Joseph Bertino ,Mark Stein ,Wafik S El-Deiry

ONC201 Targets AR and AR-V7 Signaling, Reduces PSA, and Synergizes with Everolimus in Prostate Cancer

ONC201 靶向 AR 和 AR-V7 信号,降低 PSA,并与前列腺癌中的依维莫司产生协同作用

Avital Lev, Amriti R Lulla, Brian C Ross, Marie D Ralff, Petr B Makhov, David T Dicker, Wafik S El-Deiry

TRAIL pathway targeting therapeutics

TRAIL通路靶向治疗

Ralff, Marie D; El-Deiry, Wafik S

Role of Dopamine Receptors in the Anticancer Activity of ONC201

多巴胺受体在 ONC201 抗癌活性中的作用

Christina Leah B Kline, Marie D Ralff, Amriti R Lulla, Jessica M Wagner, Phillip H Abbosh, David T Dicker, Joshua E Allen, Wafik S El-Deiry

ONC201 Demonstrates Antitumor Effects in Both Triple-Negative and Non-Triple-Negative Breast Cancers through TRAIL-Dependent and TRAIL-Independent Mechanisms

ONC201通过TRAIL依赖性和TRAIL非依赖性机制,在三阴性和非三阴性乳腺癌中均表现出抗肿瘤作用。

Ralff, Marie D; Kline, Christina L B; Küçükkase, Ozan C; Wagner, Jessica; Lim, Bora; Dicker, David T; Prabhu, Varun V; Oster, Wolfgang; El-Deiry, Wafik S

Preclinical evaluation of the imipridone family, analogs of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212.

对伊米普利酮家族(临床阶段抗癌小分子 ONC201 的类似物)的临床前评估显示,ONC212 具有强大的抗癌作用

Wagner Jessica, Kline Christina Leah, Ralff Marie D, Lev Avital, Lulla Amriti, Zhou Lanlan, Olson Gary L, Nallaganchu Bhaskara Rao, Benes Cyril H, Allen Joshua E, Prabhu Varun V, Stogniew Martin, Oster Wolfgang, El-Deiry Wafik S