日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Combination of ONC201 and TLY012 induces selective, synergistic apoptosis in vitro and significantly delays PDAC xenograft growth in vivo

ONC201 和 TLY012 联合用药可在体外诱导选择性、协同性细胞凋亡,并显著延缓体内 PDAC 异种移植瘤的生长。

Jhaveri, Aakash V; Zhou, Lanlan; Ralff, Marie D; Lee, Young S; Navaraj, Arunasalam; Carneiro, Benedito A; Safran, Howard; Prabhu, Varun V; Ross, Eric A; Lee, Seulki; El-Deiry, Wafik S

TRAIL pathway targeting therapeutics

TRAIL通路靶向治疗

Ralff, Marie D; El-Deiry, Wafik S

ONC201 Demonstrates Antitumor Effects in Both Triple-Negative and Non-Triple-Negative Breast Cancers through TRAIL-Dependent and TRAIL-Independent Mechanisms

ONC201通过TRAIL依赖性和TRAIL非依赖性机制,在三阴性和非三阴性乳腺癌中均表现出抗肿瘤作用。

Ralff, Marie D; Kline, Christina L B; Küçükkase, Ozan C; Wagner, Jessica; Lim, Bora; Dicker, David T; Prabhu, Varun V; Oster, Wolfgang; El-Deiry, Wafik S

Preclinical evaluation of the imipridone family, analogs of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212.

对伊米普利酮家族(临床阶段抗癌小分子 ONC201 的类似物)的临床前评估显示,ONC212 具有强大的抗癌作用

Wagner Jessica, Kline Christina Leah, Ralff Marie D, Lev Avital, Lulla Amriti, Zhou Lanlan, Olson Gary L, Nallaganchu Bhaskara Rao, Benes Cyril H, Allen Joshua E, Prabhu Varun V, Stogniew Martin, Oster Wolfgang, El-Deiry Wafik S